Influence of Vinyltrimethoxysilane on Properties of Methylene blue-loaded Silica @ Octacalcium Phosphate as Drug Delivery

Methylene blue-loaded silica (silica-MB) particles were prepared by a modified Stöber process with MB and vinyltrimethoxysilane (A171). Silica-MB@OCP powders were obtained after the deposition of octacalcium phosphate (OCP) on the surface of silica-MB by a modified Pechini process. The addition of A171 during the sol-gel process affects the phases, constitutes and core-shell structure of samples. The addition amount of A171, core-shell structure and pH value of culture solution have effects on the release behaviors of MB, i.e., cumulative release and ratio of released MB monomers versus dimers. Unlike silica-MB, the degradation percents of silica-MB@OCP increase significantly in phosphate buffer saline and lysosome-like buffer. This investigation would shed a light on the synthesis of core-shell structured drug carrier, the modulation of release behavior and the degradation of drug carrier systems in vivo.

[1]  Changhong Su,et al.  Modulation of release behaviors of methylene blue from degradable silica-methylene blue@octacalcium phosphate powders with different shell structures , 2015 .

[2]  Zhen Cheng,et al.  NIR-light-induced surface-enhanced Raman scattering for detection and photothermal/photodynamic therapy of cancer cells using methylene blue-embedded gold nanorod@SiO2 nanocomposites. , 2014, Biomaterials.

[3]  D. Zhao,et al.  Biphase stratification approach to three-dimensional dendritic biodegradable mesoporous silica nanospheres. , 2014, Nano letters.

[4]  W. Vogelsberger,et al.  Dissolution of Commercial Microscale Quartz Particles in Water at Biological-Like Conditions and Its Theoretical Description , 2013 .

[5]  G. Lin,et al.  Controllable drug release and simultaneously carrier decomposition of SiO2-drug composite nanoparticles. , 2013, Journal of the American Chemical Society.

[6]  Chengfeng Li,et al.  Enhanced photoluminescence properties of methylene blue dye encapsulated in nanosized hydroxyapatite/silica particles with core-shell structure , 2013 .

[7]  Jinbin Lin,et al.  Functionally modified monodisperse core–shell silica nanoparticles: Silane coupling agent as capping and size tuning agent , 2012 .

[8]  A. Kummel,et al.  Iron(III)-doped, silica nanoshells: a biodegradable form of silica. , 2012, Journal of the American Chemical Society.

[9]  M. Dyrba,et al.  Effect of pH on the synthesis and properties of luminescent SiO2/calcium phosphate:Eu3+ core-shell nanoparticles. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[10]  A. Winnacker,et al.  Luminescent silicate core-shell nanoparticles: synthesis, functionalization, optical, and structural properties. , 2011, Journal of colloid and interface science.

[11]  Mark B. Carter,et al.  The Targeted Delivery of Multicomponent Cargos to Cancer Cells via Nanoporous Particle-Supported Lipid Bilayers , 2011, Nature materials.

[12]  Chengfeng Li,et al.  Spherical hydroxyapatite with colloidal stability prepared in aqueous solutions containing polymer/surfactant pair , 2010 .

[13]  M. Gazzano,et al.  Collapsed Octacalcium Phosphate Stabilized by Ionic Substitutions , 2010 .

[14]  S. Minko,et al.  Fluorescent nanoparticles stabilized by poly(ethylene glycol) containing shell for pH-triggered tunable aggregation in aqueous environment. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[15]  Jun Lin,et al.  Synthesis of Magnetic, Up‐Conversion Luminescent, and Mesoporous Core–Shell‐Structured Nanocomposites as Drug Carriers , 2010 .

[16]  J. F. Stoddart,et al.  Controlled-access hollow mechanized silica nanocontainers. , 2009, Journal of the American Chemical Society.

[17]  T. Bein,et al.  Biotin-avidin as a protease-responsive cap system for controlled guest release from colloidal mesoporous silica. , 2009, Angewandte Chemie.

[18]  Chia‐Chen Li,et al.  An efficient approach to derive hydroxyl groups on the surface of barium titanate nanoparticles to improve its chemical modification ability. , 2009, Journal of colloid and interface science.

[19]  Hong Wang,et al.  A method for the preparation of stable dispersion of zero-valent iron nanoparticles , 2007 .

[20]  Hongyuan Chen,et al.  Electrochemical study of a new methylene blue/silicon oxide nanocomposition mediator and its application for stable biosensor of hydrogen peroxide. , 2005, Biosensors & bioelectronics.

[21]  Lei Su,et al.  Adsorption of Methylene Blue Dye onto Carbon Nanotubes: A Route to an Electrochemically Functional Nanostructure and Its Layer-by-Layer Assembled Nanocomposite , 2005 .

[22]  J. Molnár,et al.  Antimicrobial activity of phenothiazines. , 2004, In vivo.

[23]  Victor S-Y Lin,et al.  A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. , 2003, Journal of the American Chemical Society.