STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway.

[1]  G. Ning,et al.  High Serum Levels of Cholesterol Increase Anti-tumor Functions of Nature Killer Cells and Reduce Growth of Liver Tumors in Mice. , 2020, Gastroenterology.

[2]  J. Fernandez-Checa,et al.  STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome , 2020, Aging.

[3]  J. Marin,et al.  Models for Understanding Resistance to Chemotherapy in Liver Cancer , 2019, Cancers.

[4]  R. Andrade,et al.  Endoplasmic Reticulum Stress-induced Upregulation of STARD1 Promotes Acetaminophen-induced Acute Liver Failure. , 2019, Gastroenterology.

[5]  S. Strom,et al.  Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes , 2019, Stem cells and development.

[6]  W. Pandak,et al.  The acidic pathway of bile acid synthesis: Not just an alternative pathway , 2019, Liver research.

[7]  J. Fernandez-Checa,et al.  Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes , 2019, Redox biology.

[8]  H. Nittono,et al.  Mitochondrial oxysterol biosynthetic pathway gives evidence for CYP7B1 as controller of regulatory oxysterols , 2019, The Journal of Steroid Biochemistry and Molecular Biology.

[9]  D. Schuppan,et al.  Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis , 2019, Hepatology.

[10]  D. Calvisi,et al.  Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans , 2019, Gut.

[11]  Lei Zhao,et al.  Cholesterol attenuated the progression of DEN-induced hepatocellular carcinoma via inhibiting SCAP mediated fatty acid de novo synthesis. , 2019, Biochemical and biophysical research communications.

[12]  Hironori Yamamoto,et al.  Ezetimibe suppresses development of liver tumors by inhibiting angiogenesis in mice fed a high‐fat diet , 2019, Cancer science.

[13]  M. Febbraio,et al.  Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? , 2019, Cell metabolism.

[14]  M. Parr,et al.  Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1 , 2018, Biological chemistry.

[15]  Jun Yu,et al.  Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling , 2018, Nature Communications.

[16]  M. Karin,et al.  ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P , 2018, Cell.

[17]  Hongyang Wang,et al.  Cholesterol inhibits hepatocellular carcinoma invasion and metastasis by promoting CD44 localization in lipid rafts. , 2018, Cancer letters.

[18]  G. Giannelli,et al.  Plasma cholesterol and lipoprotein levels in relation to tumor aggressiveness and survival in HCC patients , 2018, The International journal of biological markers.

[19]  Jun Yu,et al.  Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target , 2018, Science Translational Medicine.

[20]  Rohit Kohli,et al.  The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids , 2018, Hepatology.

[21]  K. Machida,et al.  The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading , 2017, Redox biology.

[22]  S. Ferdinandusse,et al.  Bile acid analysis in human disorders of bile acid biosynthesis. , 2017, Molecular Aspects of Medicine.

[23]  J. Park,et al.  Protective role of endogenous plasmalogens against hepatic steatosis and steatohepatitis in mice , 2017, Hepatology.

[24]  A. Franke,et al.  Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis , 2017, Nature Medicine.

[25]  E. Wagner,et al.  Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation , 2017, The Journal of experimental medicine.

[26]  R. Green,et al.  Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice , 2016, Cellular and molecular gastroenterology and hepatology.

[27]  J. Fernandez-Checa,et al.  Mitochondria, cholesterol and cancer cell metabolism , 2016, Clinical and Translational Medicine.

[28]  J. Bruix,et al.  Evidence-Based Diagnosis, Staging, and Treatment of Patients With Hepatocellular Carcinoma. , 2016, Gastroenterology.

[29]  T. Tsai,et al.  Body mass index and cholesterol level predict surgical outcome in patients with hepatocellular carcinoma in Taiwan - a cohort study , 2016, Oncotarget.

[30]  Hua Li,et al.  Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling. , 2016, American journal of physiology. Gastrointestinal and liver physiology.

[31]  D. Brenner,et al.  Ezetimibe for the Treatment of Nonalcoholic Steatohepatitis: Assessment by Novel Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Randomized Trial (MOZART Trial) , 2015, Hepatology.

[32]  M. Karin,et al.  ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. , 2014, Cancer cell.

[33]  S. Dooley,et al.  Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. , 2013, The Journal of clinical investigation.

[34]  H. Land,et al.  Anticancer activity of the cholesterol exporter ABCA1 gene. , 2012, Cell reports.

[35]  A. Sanyal,et al.  Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. , 2012, Cell metabolism.

[36]  F. Bäckhed,et al.  Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. , 2013, Cell metabolism.

[37]  B. J. Clark,et al.  The mammalian START domain protein family in lipid transport in health and disease. , 2012, The Journal of endocrinology.

[38]  P. Siersema,et al.  Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. , 2010, Biochimica et biophysica acta.

[39]  Jun Hee Lee,et al.  Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression , 2010, Cell.

[40]  Shelly C. Lu,et al.  CD133+ liver cancer stem cells from methionine adenosyl transferase 1A–deficient mice demonstrate resistance to transforming growth factor (TGF)‐β–induced apoptosis , 2009, Hepatology.

[41]  J. Fernandez-Checa,et al.  Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. , 2009, Journal of hepatology.

[42]  B. Stiles,et al.  Expansion of CD133‐Expressing Liver Cancer Stem Cells in Liver‐Specific Phosphatase and Tensin Homolog Deleted on Chromosome 10‐Deleted Mice , 2009, Stem cells.

[43]  M. Saito,et al.  Cholesterol effects on BAX pore activation. , 2008, Journal of molecular biology.

[44]  J. Prieto,et al.  Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma. , 2008, Cancer research.

[45]  J. Martinou,et al.  Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes , 2008, Cell Death and Differentiation.

[46]  Michael F Clarke,et al.  The biology of cancer stem cells. , 2007, Annual review of cell and developmental biology.

[47]  J. Ward,et al.  Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. , 2007, Carcinogenesis.

[48]  Yun Yen,et al.  Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. , 2007, Cancer research.

[49]  A. Colell,et al.  Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. , 2006, Cell metabolism.

[50]  Richard J. Thompson,et al.  Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency , 2006, Hepatology.

[51]  P. Hylemon,et al.  Overexpression of cholesterol transporter StAR increases In Vivo rates of bile acid synthesis in the rat and mouse , 2004, Hepatology.

[52]  Michael J Thun,et al.  Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. , 2003, The New England journal of medicine.

[53]  P. Hylemon,et al.  Transport of Cholesterol into Mitochondria Is Rate-limiting for Bile Acid Synthesis via the Alternative Pathway in Primary Rat Hepatocytes* , 2002, The Journal of Biological Chemistry.

[54]  Harri Vainio,et al.  Overweight, obesity, and cancer risk. , 2002, The Lancet. Oncology.

[55]  E. Sandgren,et al.  Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes. , 2000, The American journal of pathology.

[56]  ndrea,et al.  Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. , 1996, The New England journal of medicine.

[57]  P. Elustondo,et al.  Mitochondrial cholesterol import. , 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[58]  C. Tomasetto,et al.  START ships lipids across interorganelle space. , 2014, Biochimie.

[59]  J. Llovet,et al.  Medical therapies for hepatocellular carcinoma: a critical view of the evidence , 2013, Nature Reviews Gastroenterology &Hepatology.

[60]  C. Gonçalves,et al.  [Hepatocellular carcinoma]. , 1988, Arquivos de gastroenterologia.