High‐frequency electrical conduction block of mammalian peripheral motor nerve

A quick‐acting, quick‐reversing method for blocking action potentials in peripheral nerves could be used in the treatment of muscle spasticity and pain. A high‐frequency alternating‐current (HFAC) sinusoidal waveform is one possible means for providing this type of block. HFAC was used to block peripheral motor nerve activity in an in vivo mammalian model. Frequencies from 10 to 30 kHZ at amplitudes of between 2 and 10 V were investigated. A complete and reversible motor block was obtained at all frequencies. The block threshold amplitudes showed a linear relationship with frequency, the lowest threshold being at 10 kHZ. HFAC block has three phases: an onset response; a period of asynchronous firing; and a steady state of complete or partial block. The onset response and the asynchronous firing can be minimized by using an optimal frequency–amplitude combination. In general, the onset response was lowest for the combination of 30 kHZ and 10 V. Muscle Nerve, 2005

[1]  M. Solomonow,et al.  Orderly stimulation of skeletal muscle motor units with tripolar nerve cuff electrode , 1989, IEEE Transactions on Biomedical Engineering.

[2]  R W Gerard,et al.  The ‘inhibitory’ effect of high‐frequency stimulation and the excitation state of nerve , 1935, The Journal of physiology.

[3]  M M Elhilali,et al.  Reduction of bladder outlet resistance by selective stimulation of the ventral sacral root using high frequency blockade: a chronic study in spinal cord transected dogs. , 2001, The Journal of urology.

[4]  B. Campbell,et al.  Further studies on asynchronous firing and block of peripheral nerve conduction. , 1966, Bulletin of the Los Angeles neurological societies.

[5]  G. Brindley.  The first 500 sacral anterior root stimulators: implant failures and their repair , 1995, Paraplegia.

[6]  S. Binder-Macleod,et al.  Comparison of fatigue produced by various electrical stimulation trains. , 2001, Acta physiologica Scandinavica.

[7]  Chou-Ching K. Lin,et al.  High frequency block of selected axons using an implantable microstimulator , 2004, Journal of Neuroscience Methods.

[8]  T Nakada,et al.  Modulation of the urethral pressure by high-frequency block stimulus in dogs. , 1994, European urology.

[9]  Changfeng Tai,et al.  Block of external urethral sphincter contraction by high frequency electrical stimulation of pudendal nerve. , 2004, The Journal of urology.

[10]  M Y WOO,et al.  ASYNCHRONOUS FIRING AND BLOCK OF PERIPHERAL NERVE CONDUCTION BY 20 KC ALTERNATING CURRENT. , 1964, Bulletin of the Los Angeles Neurological Society.

[11]  B. Bigland-ritchie,et al.  Muscle fatigue induced by stimulation with and without doublets , 2000, Muscle & nerve.

[12]  V. Krauthamer,et al.  Effects of high-rate electrical stimulation upon firing in modelled and real neurons , 2002, Medical and Biological Engineering and Computing.

[13]  K. Kilgore,et al.  Nerve conduction block utilising high-frequency alternating current , 2004, Medical and Biological Engineering and Computing.

[14]  D. Mcneal,et al.  Response of single alpha motoneurons to high-frequency pulse trains. Firing behavior and conduction block phenomenon. , 1986, Applied neurophysiology.

[15]  E Eldred,et al.  Control of muscle contractile force through indirect high-frequency stimulation. , 1983, American journal of physical medicine.

[16]  Brian J. Andrews,et al.  Localized electrical nerve blocking , 1996, IEEE Transactions on Biomedical Engineering.

[17]  J. A. TANNER,et al.  Reversible Blocking of Nerve Conduction by Alternating-Current Excitation , 1962, Nature.

[18]  N. Bhadra,et al.  Direct current electrical conduction block of peripheral nerve , 2004, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[19]  Neuromuscular Stimulation for Motor Neuroprosthesis in Hemiplegia , 2000 .

[20]  G. Brindley,et al.  The first 500 patients with sacral anterior root stimulator implants: general description , 1994, Paraplegia.

[21]  Jeffrey C. Petruska,et al.  Anodally focused polarization of peripheral nerve allows discrimination of myelinated and unmyelinated fiber input to brainstem nuclei , 1998, Experimental Brain Research.

[22]  W. Durfee,et al.  Reducing muscle fatigue in FES applications by stimulating with N-let pulse trains , 1995, IEEE Transactions on Biomedical Engineering.

[23]  A. E. Hines,et al.  Hand opening by electrical stimulation in patients with spastic hemiplegia , 1995 .