Magnetization transfer from inhomogeneously broadened lines (ihMT): Improved imaging strategy for spinal cord applications

Inhomogeneous magnetization transfer (ihMT) shows great promise for specific imaging of myelinated tissues. Whereas the ihMT technique has been previously applied in brain applications, the current report presents a strategy for cervical spinal cord (SC) imaging free of cerebrospinal fluid (CSF) pulsatility artifacts.

[1]  T. Jaermann,et al.  A preliminary study of the effects of trigger timing on diffusion tensor imaging of the human spinal cord. , 2006, AJNR. American journal of neuroradiology.

[2]  David C. Alsop,et al.  Minimizing the effects of magnetization transfer asymmetry on inhomogeneous magnetization transfer (ihMT) at ultra-high magnetic field (11.75 T) , 2016, Magnetic Resonance Materials in Physics, Biology and Medicine.

[3]  K. Uğurbil,et al.  Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo , 2007, Magnetic resonance in medicine.

[4]  Andrea Bergmann,et al.  Statistical Parametric Mapping The Analysis Of Functional Brain Images , 2016 .

[5]  R. Hodges,et al.  High resolution 1H nuclear magnetic resonance of a transmembrane peptide. , 1995, Biophysical journal.

[6]  J. Ranjeva,et al.  Tract‐specific and age‐related variations of the spinal cord microstructure: a multi‐parametric MRI study using diffusion tensor imaging (DTI) and inhomogeneous magnetization transfer (ihMT) , 2016, NMR in biomedicine.

[7]  Xiaoping Hu,et al.  Correction for the T1 effect incorporating flip angle estimated by Kalman filter in cardiac‐gated functional MRI , 2013, Magnetic resonance in medicine.

[8]  J. R. Baker,et al.  Imaging subcortical auditory activity in humans , 1998, Human brain mapping.

[9]  S. Singer,et al.  High‐resolution MAS NMR spectroscopy detection of the spin magnetization exchange by cross‐relaxation and chemical exchange in intact cell lines and human tissue specimens , 2006, Magnetic resonance in medicine.

[10]  Mei Hong,et al.  Membrane protein topology probed by (1)H spin diffusion from lipids using solid-state NMR spectroscopy. , 2002, Journal of the American Chemical Society.

[11]  Julien Cohen-Adad,et al.  A reliable spatially normalized template of the human spinal cord — Applications to automated white matter/gray matter segmentation and tensor-based morphometry (TBM) mapping of gray matter alterations occurring with age , 2015, NeuroImage.

[12]  D. Alsop,et al.  Magnetization transfer from inhomogeneously broadened lines: A potential marker for myelin , 2015, Magnetic Resonance in Medicine.

[13]  D. Alsop,et al.  Interpretation of magnetization transfer from inhomogeneously broadened lines (ihMT) in tissues as a dipolar order effect within motion restricted molecules. , 2015, Journal of magnetic resonance.

[14]  Julien Cohen-Adad,et al.  White matter atlas of the human spinal cord with estimation of partial volume effect , 2015, NeuroImage.

[15]  M. Sdika,et al.  Construction of an in vivo human spinal cord atlas based on high-resolution MR images at cervical and thoracic levels: preliminary results , 2014, Magnetic Resonance Materials in Physics, Biology and Medicine.

[16]  A. M. Portis,et al.  Electronic Structure of F Centers: Saturation of the Electron Spin Resonance , 1953 .

[17]  D. L. Collins,et al.  Framework for integrated MRI average of the spinal cord white and gray matter: The MNI–Poly–AMU template , 2014, NeuroImage.

[18]  D. Alsop,et al.  Magnetization transfer from inhomogeneously broadened lines (ihMT): Experimental optimization of saturation parameters for human brain imaging at 1.5 Tesla , 2015, Magnetic resonance in medicine.

[19]  K P Whittall,et al.  Different magnetization transfer effects exhibited by the short and long T2 components in human brain , 2000, Magnetic resonance in medicine.

[20]  F. Harris On the use of windows for harmonic analysis with the discrete Fourier transform , 1978, Proceedings of the IEEE.

[21]  John C Gore,et al.  Origins of the ultrashort‐T2 1H NMR signals in myelinated nerve: A direct measure of myelin content? , 2011, Magnetic resonance in medicine.

[22]  N. Baumann,et al.  Biology of oligodendrocyte and myelin in the mammalian central nervous system. , 2001, Physiological reviews.

[23]  U Klose,et al.  The Influence of Pulse and Respiration on Spinal Cerebrospinal Fluid Pulsation , 2004, Investigative radiology.

[24]  A. Anderson,et al.  Effects of cord motion on diffusion imaging of the spinal cord , 2006, Magnetic resonance in medicine.