Signal transduction in the erythropoietin receptor system.
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R. Gregory | D. Wojchowski | D. Wojchowski | C. Miller | R. Gregory | T. Pircher | A. K. Pandit | Chris P. Miller | Ajay K. Pandit
[1] J. Price,et al. Distinct roles of JNKs/p38 MAP kinase and ERKs in apoptosis and survival of HCD-57 cells induced by withdrawal or addition of erythropoietin. , 1999, Blood.
[2] D. Wojchowski,et al. A minimal cytoplasmic subdomain of the erythropoietin receptor mediates erythroid and megakaryocytic cell development. , 1999, Blood.
[3] M. Kubo,et al. Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice , 1999, Molecular and Cellular Biology.
[4] Arun Sharma,et al. Engagement of Gab1 and Gab2 in Erythropoietin Signaling* , 1999, The Journal of Biological Chemistry.
[5] H. Lodish,et al. Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice A Direct Role for Stat5 in Bcl-XL Induction , 1999, Cell.
[6] B. Beattie,et al. Identification of the Erythropoietin Receptor Domain Required for Calcium Channel Activation* , 1999, The Journal of Biological Chemistry.
[7] C. Persson. Clinical research, or classical clinical research? , 1999, Nature Medicine.
[8] S. Orkin,et al. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. , 1999, Blood.
[9] K. Noguchi,et al. Physical and Functional Interactions between Pim-1 Kinase and Cdc25A Phosphatase , 1999, The Journal of Biological Chemistry.
[10] E. Puré,et al. The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[11] K. Koshimura,et al. Effects of Erythropoietin on Neuronal Activity , 1999, Journal of neurochemistry.
[12] E. Mackenzie,et al. A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[13] J. Johnston,et al. Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain , 1999, Genes to cells : devoted to molecular & cellular mechanisms.
[14] A. Elefanty,et al. Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1 , 1999, Leukemia.
[15] K. Todokoro,et al. Activation of hematopoietic progenitor kinase-1 by erythropoietin. , 1999, Blood.
[16] J. Schlessinger,et al. The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases , 1999, Oncogene.
[17] A. Yoshimura,et al. APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl , 1999, Leukemia.
[18] C. Lacombe,et al. Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and phosphatidylinositol 3-kinase. , 1999, Blood.
[19] Susan S. Taylor,et al. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. , 1999, Molecular cell.
[20] A. Yoshimura,et al. The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop , 1999, The EMBO journal.
[21] Itaru Matsumura,et al. Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine‐dependent growth of hematopoietic cells , 1999, The EMBO journal.
[22] A. Miyajima,et al. Role of cytokine signaling molecules in erythroid differentiation of mouse fetal liver hematopoietic cells: functional analysis of signaling molecules by retrovirus-mediated expression. , 1999, Blood.
[23] A. Danilkovitch,et al. Kinases involved in MSP/RON signaling , 1999, Journal of leukocyte biology.
[24] K. Okkenhaug,et al. Socs1 binds to multiple signalling proteins and suppresses Steel factor‐dependent proliferation , 1999, The EMBO journal.
[25] I. Wilson,et al. Erythropoietin receptor activation by a ligand-induced conformation change. , 1999, Science.
[26] C. Marshall,et al. Cooperation of p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways during Granulocyte Colony-stimulating Factor-induced Hemopoietic Cell Proliferation* , 1999, The Journal of Biological Chemistry.
[27] H. Sakamoto,et al. APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis , 1999, Oncogene.
[28] P. Mayeux,et al. Physical and Functional Interaction between p72 syk and Erythropoietin Receptor* , 1998, The Journal of Biological Chemistry.
[29] A. Yoshimura,et al. Cytokine‐inducible SH2 protein (CIS3) and JAK2 binding protein (JAB) abolish prolactin receptor‐mediated STAT5 signaling , 1998, FEBS letters.
[30] B. Druker,et al. Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets. , 1998, Blood.
[31] S. Masuda,et al. Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery. , 1998, Biochemical and biophysical research communications.
[32] A. Yoshimura,et al. The CIS family: negative regulators of JAK-STAT signaling. , 1998, Cytokine & growth factor reviews.
[33] J. C. Pratt,et al. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. , 1998, Molecular cell.
[34] A. Yoshimura,et al. Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation , 1998, The Journal of Biological Chemistry.
[35] F. Gouilleux,et al. A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B , 1998, Molecular and Cellular Biology.
[36] R. Eisenman,et al. Pim-1 kinase and p100 cooperate to enhance c-Myb activity. , 1998, Molecular cell.
[37] Robert M. Stroud,et al. Efficiency of signalling through cytokine receptors depends critically on receptor orientation , 1998, Nature.
[38] Y Nagata,et al. Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation. , 1998, Blood.
[39] H. Lodish,et al. The Prolactin Receptor Rescues EpoR−/− Erythroid Progenitors and Replaces EpoR in a Synergistic Interaction With c-kit , 1998 .
[40] Z. Zhao,et al. Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis , 1998 .
[41] J. Cleveland,et al. Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies. , 1998, Genes & development.
[42] R. Gregory,et al. Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization. , 1998, Blood.
[43] B. Druker,et al. Erythropoietin Induces Tyrosine Phosphorylation of Jak2, STAT5A, and STAT5B in Primary Cultured Human Erythroid Precursors , 1998 .
[44] J. Krosl,et al. The hyperresponsiveness of cells expressing truncated erythropoietin receptors is contingent on insulin-like growth factor-1 in fetal calf serum. , 1998, Blood.
[45] J. Kinet,et al. PtdIns-3,4,5-P3 A Regulatory Nexus between Tyrosine Kinases and Sustained Calcium Signals , 1998, Cell.
[46] M. Birrer,et al. AP1 Regulation of Proliferation and Initiation of Apoptosis in Erythropoietin-Dependent Erythroid Cells , 1998, Molecular and Cellular Biology.
[47] R. Kralovics,et al. Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia. , 1998, The Journal of clinical investigation.
[48] T. Hunter,et al. The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136 , 1998, Current Biology.
[49] M. Goldsmith,et al. Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[50] G. Krystal,et al. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. , 1998, Genes & development.
[51] Michael P. Brown,et al. Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses , 1998, Cell.
[52] W. Yang,et al. SHP-1 phosphatase C-terminus interacts with novel substrates p32/p30 during erythropoietin and interleukin-3 mitogenic responses. , 1998, Blood.
[53] N. Miyasaka,et al. Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. , 1998, Blood.
[54] A. Cumano,et al. Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis , 1998, Cell.
[55] J. Marine,et al. Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors , 1998, Cell.
[56] J L Cleveland,et al. Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. , 1998, Genes & development.
[57] U. Ikeda,et al. Tec and Jak2 Kinases Cooperate to Mediate Cytokine-Driven Activation of c- fos Transcription , 1998 .
[58] M. Wasik,et al. The role of insulin (INS) and insulin-like growth factor-I (IGF-I) in regulating human erythropoiesis. Studies in vitro under serum-free conditions – comparison to other cytokines and growth factors , 1998, Leukemia.
[59] N. Leslie,et al. Both stroma and stem cell factor maintain long-term growth of ELM erythroleukemia cells, but only stroma prevents erythroid differentiation in response to erythropoietin and interleukin-3. , 1998, Blood.
[60] M. McMullin,et al. Erythrocytosis due to a mutation in the erythropoietin receptor gene , 1998, British journal of haematology.
[61] V. Broudy,et al. Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer. , 1998, Blood.
[62] H. Lodish,et al. Tyrosine Residues within the Intracellular Domain of the Erythropoietin Receptor Mediate Activation of AP-1 Transcription Factors* , 1998, The Journal of Biological Chemistry.
[63] J. Goldman,et al. Interleukin 3 (IL-3), but not stem cell factor (SCF) increases self-renewal by human erythroid burst-forming units (BFU-E) in vitro. , 1998, Cytokine.
[64] A. Yoshimura. The CIS/JAB family: novel negative regulators of JAK signaling pathways , 1998, Leukemia.
[65] J. Díaz,et al. Dimerization Properties of Human BAD , 1997, The Journal of Biological Chemistry.
[66] S. Fesik,et al. Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL , 1997, Molecular and cellular biology.
[67] A. Kraft,et al. Enforced expression of the Mr 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells. , 1997, Cancer research.
[68] D. Seshasayee,et al. Mechanisms of stem cell factor and erythropoietin proliferative co-signaling in FDC2-ER cells. , 1997, Blood.
[69] L. Peso,et al. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. , 1997, Science.
[70] H. Sakamoto,et al. Cloning and characterization of novel CIS family genes. , 1997, Biochemical and biophysical research communications.
[71] T. Saito,et al. Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells. , 1997, Biochemical and biophysical research communications.
[72] C. Lacombe,et al. Erythropoietin Induces the Tyrosine Phosphorylation of Insulin Receptor Substrate-2 , 1997, The Journal of Biological Chemistry.
[73] A. Kahn,et al. Bcl-2 targeted overexpression into the erythroid lineage of transgenic mice delays but does not prevent the apoptosis of erythropoietin-deprived erythroid progenitors. , 1997, Blood.
[74] K. Kishi,et al. Primary familial polycythaemia associated with a novel point mutation in the erythropoietin receptor , 1997, British journal of haematology.
[75] S. Korsmeyer,et al. BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity* , 1997, The Journal of Biological Chemistry.
[76] K. Noguchi,et al. Pim-1 kinase stimulates c-Myc-mediated death signaling upstream of caspase-3 (CPP32)-like protease activation , 1997, Oncogene.
[77] D. Wojchowski,et al. Hematopoietic cell phosphatase negatively regulates erythropoietin-induced hemoglobinization in erythroleukemic SKT6 cells. , 1997, Blood.
[78] G. Feldman,et al. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. , 1997, Blood.
[79] S. Orkin,et al. A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development , 1997, Molecular and cellular biology.
[80] J. Tavernier,et al. The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. , 1997, Blood.
[81] R. Kralovics,et al. Two new EPO receptor mutations: truncated EPO receptors are most frequently associated with primary familial and congenital polycythemias. , 1997, Blood.
[82] R. Plevin,et al. Stress-activated protein kinases: activation, regulation and function. , 1997, Cellular signalling.
[83] V. Broudy,et al. Stem cell factor and hematopoiesis. , 1997, Blood.
[84] M. Bondurant,et al. The roles of Bcl-X(L) and apopain in the control of erythropoiesis by erythropoietin. , 1997, Blood.
[85] R. Snell,et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[86] I. Weissman,et al. Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice , 1997, Cell.
[87] A. Strasser,et al. Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice , 1997, Cell.
[88] Takaho A. Endo,et al. A new protein containing an SH2 domain that inhibits JAK kinases , 1997, Nature.
[89] Warren S. Alexander,et al. A family of cytokine-inducible inhibitors of signalling , 1997, Nature.
[90] T. Taniguchi,et al. The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[91] M. Arcasoy,et al. Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. , 1997, Blood.
[92] R. Schmitz,et al. Identification of phosphopeptide ligands for the Src-homology 2 (SH2) domain of Grb2 by phage display. , 1997, European journal of biochemistry.
[93] H. Lodish,et al. The Prolactin Receptor and Severely Truncated Erythropoietin Receptors Support Differentiation of Erythroid Progenitors* , 1997, The Journal of Biological Chemistry.
[94] A. Miyajima,et al. A possible involvement of Stat5 in erythropoietin-induced hemoglobin synthesis. , 1997, Biochemical and biophysical research communications.
[95] D. Alexander,et al. The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.
[96] J. Schrader,et al. Activation of the stress-activated protein kinases by multiple hematopoietic growth factors with the exception of interleukin-4. , 1997, Blood.
[97] I. Kerr,et al. Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop , 1997, Molecular and cellular biology.
[98] R. Ofir,et al. Identification of genes induced by interleukin-3 and erythropoietin via the Jak-Stat5 pathway using enhanced differential display-reverse southern. , 1997, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
[99] A. Yoshimura,et al. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. , 1997, Blood.
[100] K. Norga,et al. Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding. , 1997, Blood.
[101] B. Druker,et al. Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins. , 1997, Blood.
[102] E. Nishida,et al. Activation of JNK signaling pathway by erythropoietin, thrombopoietin, and interleukin-3. , 1997, Blood.
[103] J. Krosl,et al. The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation. , 1997, Leukemia.
[104] S. Klinken,et al. Lyn tyrosine kinase is essential for erythropoietin‐induced differentiation of J2E erythroid cells , 1997, The EMBO journal.
[105] H. Lodish,et al. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[106] S. Ezzat,et al. Insulin-like growth factor binding protein-1 is elevated in patients with polycythemia vera and stimulates erythroid burst formation in vitro. , 1997, Blood.
[107] K. Penta,et al. Distinct Signaling from Stem Cell Factor and Erythropoietin in HCD57 Cells* , 1997, The Journal of Biological Chemistry.
[108] H. Lodish,et al. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[109] T. Roberts,et al. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways , 1997, Molecular and cellular biology.
[110] L. Hennighausen,et al. Stat5a is mandatory for adult mammary gland development and lactogenesis. , 1997, Genes & development.
[111] M. Boyle,et al. Homodimerization of erythropoietin receptor by a bivalent monoclonal antibody triggers cell proliferation and differentiation of erythroid precursors. , 1997, Blood.
[112] J. Borst,et al. The Cbl family of signal transduction molecules. , 1997, Critical reviews in oncogenesis.
[113] R. Gregory,et al. Epo-induced hemoglobinization of SKT6 cells is mediated by minimal cytoplasmic domains of the Epo or prolactin receptors without modulation of GATA-1 or EKLF. , 1997, Growth factors.
[114] Elizabeth Yang,et al. Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL , 1996, Cell.
[115] A. Sytkowski,et al. Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation. , 1996, The Journal of biological chemistry.
[116] D. Chang,et al. Activation of the Erythropoietin (EPO) Receptor by Bivalent Anti-EPO Receptor Antibodies* , 1996, The Journal of Biological Chemistry.
[117] L. Zon,et al. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[118] U Klingmüller,et al. Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[119] Enrico A. Stura,et al. Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å , 1996, Science.
[120] T. He,et al. The box1 Domain of the Erythropoietin Receptor Specifies Janus Kinase 2 Activation and Functions Mitogenically within an Interleukin 2 β-Receptor Chimera* , 1996, The Journal of Biological Chemistry.
[121] H. Broxmeyer,et al. Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis. , 1996, Blood.
[122] B. Groner,et al. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. , 1996, The EMBO journal.
[123] A. Miyajima,et al. Suppression of interleukin‐3‐induced gene expression by a C‐terminal truncated Stat5: role of Stat5 in proliferation. , 1996, The EMBO journal.
[124] J. Gogusev,et al. Nephrology Dialysis Transplantation Direct effect of erythropoietin on rat vascular smooth-muscle cell via a putative erythropoietin receptor , 2005 .
[125] J. Ihle,et al. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response , 1996, Molecular and cellular biology.
[126] Norbert Perrimon,et al. marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs , 1996, Cell.
[127] V. D’Agati,et al. Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. , 1996, Genes & development.
[128] T. Tan,et al. Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis (*) , 1996, The Journal of Biological Chemistry.
[129] I. Adham,et al. Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene , 1996, Molecular reproduction and development.
[130] T. Chiba,et al. Erythropoietin stimulates proliferation of rat-cultured gastric mucosal cells. , 1996, Digestion.
[131] Y. Yazaki,et al. Proto-oncogene products Vav and c-Cbl are involved in the signal transduction through Grb2/Ash in hematopoietic cells. , 1996, Acta haematologica.
[132] D Grillot,et al. Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2. , 1996, Blood.
[133] Michael E. Greenberg,et al. Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis , 1995, Science.
[134] J. Krosl,et al. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin‐induced cell proliferation and Stat5 activation. , 1995, The EMBO journal.
[135] J. Ihle. Cytokine receptor signalling , 1995, Nature.
[136] G. Krystal,et al. Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3-Kinase Activity (*) , 1995, The Journal of Biological Chemistry.
[137] Rudolf Jaenisch,et al. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor , 1995, Cell.
[138] H. Lodish,et al. Interaction of the erythropoietin and stem-cell-factor receptors , 1995, Nature.
[139] H. Mano,et al. Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. , 1995, Oncogene.
[140] R. Rees,et al. Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3 , 1995, FEBS letters.
[141] Paulo N. Correa,et al. Increased basal and induced tyrosine phosphorylation of the insulin-like growth factor I receptor beta subunit in circulating mononuclear cells of patients with polycythemia vera. , 1995, Blood.
[142] K. Muta,et al. Stem cell factor retards differentiation of normal human erythroid progenitor cells while stimulating proliferation. , 1995, Blood.
[143] G. Semenza,et al. Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin. , 1995, Blood.
[144] I. Sakai,et al. Regions of the JAK2 Tyrosine Kinase Required for Coupling to the Growth Hormone Receptor (*) , 1995, The Journal of Biological Chemistry.
[145] J. Johnston,et al. Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2. , 1995, Blood.
[146] N. Copeland,et al. A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors. , 1995, The EMBO journal.
[147] E. Krebs,et al. The MAPK signaling cascade , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[148] Y. Yazaki,et al. The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells (*) , 1995, The Journal of Biological Chemistry.
[149] T. He,et al. Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway , 1995, The Journal of Biological Chemistry.
[150] D. Levy,et al. Prolactin, growth hormone, erythropoietin and granulocyte‐macrophage colony stimulating factor induce MGF‐Stat5 DNA binding activity. , 1995, The EMBO journal.
[151] Bernd Groner,et al. Mediation of Growth Hormone-dependent Transcriptional Activation by Mammary Gland Factor/Stat 5 (*) , 1995, The Journal of Biological Chemistry.
[152] H. Broxmeyer,et al. Involvement of SH2-containing Phosphotyrosine Phosphatase Syp in Erythropoietin Receptor Signal Transduction Pathways (*) , 1995, The Journal of Biological Chemistry.
[153] al. et,et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice , 1995, Science.
[154] Ursula Klingmüller,et al. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals , 1995, Cell.
[155] C. Walsh,et al. Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains (*) , 1995, The Journal of Biological Chemistry.
[156] B. Neel,et al. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development , 1995, Cell.
[157] S. Shoelson,et al. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS , 1995, Molecular and cellular biology.
[158] S. Korsmeyer,et al. Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death , 1995, Cell.
[159] O. Miura,et al. Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites. , 1995, Blood.
[160] J. Ihle,et al. Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor. , 1994, Blood.
[161] N. Aoki,et al. Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. , 1994, The Journal of biological chemistry.
[162] K. Siminovitch,et al. Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function. , 1994, Clinical immunology and immunopathology.
[163] P. Tempst,et al. Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells. , 1994, Blood.
[164] P Bork,et al. The immunoglobulin fold. Structural classification, sequence patterns and common core. , 1994, Journal of molecular biology.
[165] B. Groner,et al. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. , 1994, The EMBO journal.
[166] T. He,et al. Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2. , 1994, The Journal of biological chemistry.
[167] N. Komatsu,et al. Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line. , 1994, The Journal of biological chemistry.
[168] A. Wilks,et al. Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin‐erythropoietin receptor chimera expressed in lymphoid cells. , 1994, The EMBO journal.
[169] H. Ruley,et al. Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53 , 1994, Molecular and cellular biology.
[170] R. Jaster,et al. Rapid activation of the MAP kinase pathway in hematopoietic cells by erythropoietin, granulocyte-macrophage colony-stimulating factor and interleukin-3. , 1994, Cellular signalling.
[171] W. Farrar,et al. Activation of receptor-associated tyrosine kinase JAK2 by prolactin. , 1994, The Journal of biological chemistry.
[172] R. Pacifici,et al. Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligand. , 1994, The Journal of biological chemistry.
[173] Paulo N. Correa,et al. Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: studies in an improved serum-free medium [see comments] , 1994 .
[174] S. Korsmeyer,et al. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair , 1993, Cell.
[175] G. Krystal,et al. Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells. , 1993, The Journal of biological chemistry.
[176] G. Krystal,et al. Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. , 1993, Blood.
[177] O. Silvennoinen,et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin , 1993, Cell.
[178] O. Silvennoinen,et al. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase , 1993, Cell.
[179] K. Siminovitch,et al. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene , 1993, Nature Genetics.
[180] N. Copeland,et al. Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit. , 1993, Oncogene.
[181] D. Quelle,et al. Mutations in the WSAWSE and cytosolic domains of the erythropoietin receptor affect signal transduction and ligand binding and internalization , 1992, Molecular and cellular biology.
[182] T. Le,et al. Sustained expression of the pim-1 kinase is specifically induced in myeloid cells by cytokines whose receptors are structurally related. , 1992, Oncogene.
[183] G. Stark,et al. High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[184] A. Berns,et al. Carcinogen-induced lymphomagenesis in pim-1 transgenic mice: dose dependence and involvement of myc and ras. , 1991, Cancer research.
[185] H. Lodish,et al. Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity , 1990, Nature.
[186] J. Bazan,et al. Structural design and molecular evolution of a cytokine receptor superfamily. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[187] A. D’Andrea,et al. Human erythropoietin receptor: cloning, expression, and biologic characterization. , 1990, Blood.
[188] M. Koury,et al. Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. , 1990, Science.
[189] K. Miyazono,et al. Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin , 1989, Journal of cellular physiology.
[190] H. Lodish,et al. Expression cloning of the murine erythropoietin receptor , 1989, Cell.
[191] S. Klinken,et al. In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[192] Y. Sakaki,et al. Hematopoietic growth factors (BPA and Epo) induce the expressions of c-myc and c-fos proto-oncogenes in normal human erythroid progenitors. , 1988, Leukemia research.
[193] M. Karin,et al. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor , 1987, Cell.
[194] Y. Ikawa,et al. Specific binding of erythropoietin to its receptor on responsive mouse erythroleukemia cells. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[195] Wim Quint,et al. Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region , 1984, Cell.
[196] E. Dessypris,et al. Effect of pure erythropoietin on DNA‐synthesis by human marrow day 15 erythroid burst forming units in short‐term liquid culture , 1984, British journal of haematology.