Genes, language, and the nature of scientific explanations: The case of Williams syndrome

In this article, we discuss two experiments of nature and their implications for the sciences of the mind. The first, Williams syndrome, bears on one of cognitive science's holy grails: the possibility of unravelling the causal chain between genes and cognition. We sketch the outline of a general framework to study the relationship between genes and cognition, focusing as our case study on the development of language in individuals with Williams syndrome. Our approach emphasizes the role of three key ingredients: the need to specify a clear level of analysis, the need to provide a theoretical account of the relevant cognitive structure at that level, and the importance of the (typical) developmental process itself. The promise offered by the case of Williams syndrome has also given rise to two strongly conflicting theoretical approaches—modularity and neuroconstructivism—themselves offshoots of a perennial debate between nativism and empiricism. We apply our framework to explore the tension created by these two conflicting perspectives. To this end, we discuss a second experiment of nature, which allows us to compare the two competing perspectives in what comes close to a controlled experimental setting. From this comparison, we conclude that the “meaningful debate assumption”, a widespread assumption suggesting that neuroconstructivism and modularity address the same questions and represent genuine theoretical alternatives, rests on a fallacy.

[1]  S. Carey The Origin of Concepts , 2000 .

[2]  A. Baddeley,et al.  Verbal and nonverbal abilities in the Williams syndrome phenotype: evidence for diverging developmental trajectories. , 1998, Journal of child psychology and psychiatry, and allied disciplines.

[3]  Michael S. C. Thomas,et al.  Modeling language acquisition in atypical phenotypes. , 2003, Psychological review.

[4]  Michael S. C. Thomas,et al.  Can Developmental Disorders Reveal the Component Parts of the Human Language Faculty? , 2005 .

[5]  M. Racsmány,et al.  Morphological patterns in Hungarian children with Williams syndrome and the rule debates , 2003, Brain and Language.

[6]  J. Musolino,et al.  Children's command of quantification , 2002, Cognition.

[7]  C Caltagirone,et al.  Short-term memory in persons with intellectual disabilities and Down's syndrome. , 1995, Journal of intellectual disability research : JIDR.

[8]  Michael S. C. Thomas,et al.  Language acquisition in developmental disorders , 2010 .

[9]  J. Fodor,et al.  The modularity of thought and the epidemiology of representations , 2011 .

[10]  S. Crain,et al.  Covert downward entailment in child English and Japanese , 2006 .

[11]  Stephen Crain,et al.  Why no child or adult must learn De Morgans laws , 2002 .

[12]  Noam Chomsky,et al.  वाक्यविन्यास का सैद्धान्तिक पक्ष = Aspects of the theory of syntax , 1965 .

[13]  Ursula Bellugi,et al.  Dissociation between language and cognitive functions in Williams syndrome , 1988 .

[14]  Maria Teresa Guasti,et al.  Language acquisition : the growth of grammar , 2002 .

[15]  K. Wexler,et al.  Development of verbal passive in Williams syndrome. , 2010, Journal of speech, language, and hearing research : JSLHR.

[16]  E. Spelke Nativism, empiricism, and the origins of knowledge , 1998 .

[17]  M. Penke,et al.  Regular and irregular inflectional morphology in German Williams syndrome , 2004 .

[18]  Jeffrey Lidz,et al.  The Scope of Isomorphism: Turning Adults Into Children , 2003 .

[19]  Michael S.C. Thomas,et al.  What Is Typical Language Development? , 2010 .

[20]  H. Tager-Flusberg,et al.  People with Williams syndrome process faces holistically , 2003, Cognition.

[21]  M L McDade,et al.  Down syndrome and short-term memory impairment: a storage or retrieval deficit? , 1980, American journal of mental deficiency.

[22]  Chung-hye Han,et al.  V-Raising and Grammar Competition in Korean: Evidence from Negation and Quantifier Scope , 2007, Linguistic Inquiry.

[23]  Andrea Zukowski,et al.  Uncovering grammatical competence in children with Williams syndrome. , 2001 .

[24]  Virginia Volterra,et al.  Linguistic Abilities in Italian Children With Williams Syndrome , 1996, Cortex.

[25]  H. Barrett,et al.  Modularity in cognition: framing the debate. , 2006, Psychological review.

[26]  J. Zwart The Minimalist Program , 1998, Journal of Linguistics.

[27]  J. Hoffman,et al.  Explaining Selective Spatial Breakdown in Williams Syndrome: Four Principles of Normal Spatial Development and Why They Matter , 2012 .

[28]  Harald Clahsen,et al.  Words and Rules in Children with Williams Syndrome , 2001 .

[29]  S. Crain Language acquisition in the absence of experience , 1991, Behavioral and Brain Sciences.

[30]  Patricia Spallone,et al.  Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome , 1993, Nature Genetics.

[31]  J. Morton Understanding Developmental Disorders: A Causal Modelling Approach , 2005 .

[32]  L. Hildman,et al.  Kaufman Brief Intelligence Test , 1993 .

[33]  L. Cosmides,et al.  The Adapted mind : evolutionary psychology and the generation of culture , 1992 .

[34]  Constructivism, nativism, and explanatory adequacy , 1997, Behavioral and Brain Sciences.

[35]  P. Strømme,et al.  Prevalence Estimation of Williams Syndrome , 2002, Journal of child neurology.

[36]  Ursula Bellugi,et al.  Seeing either the forest or the trees: Dissociation in visuospatial processing , 1989, Brain and Cognition.

[37]  Zenon W. Pylyshyn,et al.  Computation and Cognition: Toward a Foundation for Cognitive Science , 1984 .

[38]  Susan Goldin The resilience of language : what gesture creation in deaf children can tell us about how all children learn language , 2003 .

[39]  Andrea Zukowski,et al.  Elicited production of relative clauses in children with Williams syndrome , 2009 .

[40]  N. R. Ellis Do the mentally retarded have poor memory , 1978 .

[41]  S. Pinker The language instinct : the new science of language and mind , 1994 .

[42]  E. Spelke,et al.  Nativism, empiricism, and the development of knowledge. , 1998 .

[43]  A. Karmiloff-Smith Crucial differences between developmental cognitive neuroscience and adult neuropsychology , 1997 .

[44]  B. Landau,et al.  When Theories Don't Compete: Response to Thomas, Karaminis, and Knowland's Commentary on Musolino, Chunyo, and Landau , 2010 .

[45]  J. Elman,et al.  Rethinking Innateness: A Connectionist Perspective on Development , 1996 .

[46]  Andrea Gualmini,et al.  The Role of Partitivity in Child Language , 2004 .

[47]  Stephen Crain,et al.  14. Hidden units in child language , 2007 .

[48]  H. Clahsen,et al.  Lexical and morphological skills in English-speaking children with Williams Syndrome , 2003 .

[49]  Barbara Landau,et al.  Spatial Representation: From Gene to Mind , 2012 .

[50]  S. Gelman,et al.  Mapping the Mind: Domain Specificity In Cognition And Culture , 1994 .

[51]  Y. Levy,et al.  Language Competence Across Populations: Towards a definition of Specific Language Impairment , 2003 .

[52]  Refractor Vision , 2000, The Lancet.

[53]  L. Gleitman,et al.  Language and Experience: Evidence from the Blind Child , 1988 .

[54]  Jeffrey Lidz,et al.  Why children aren't universally successful with quantification , 2006 .

[55]  Virginia Volterra,et al.  Language development in Williams Syndrome : A case study , 1996 .

[56]  T. Simpatico The Birth of the Mind: How a Tiny Number of Genes Creates the Complexities of Human Thought , 2005 .

[57]  J. Fodor The Modularity of mind. An essay on faculty psychology , 1986 .

[58]  J. Musolino The semantics and acquisition of number words: integrating linguistic and developmental perspectives , 2004, Cognition.

[59]  Andrea Zukowski,et al.  Investigating Knowledge of Complex Syntax: Insights From Experimental Studies of Williams Syndrome , 2004 .

[60]  Peter M. Duppenthaler Maturational Constraints on Language Learning , 1990 .

[61]  Jordan Grafman,et al.  Atypical cognitive deficits in developmental disorders : implications for brain function , 1994 .

[62]  H. Clahsen,et al.  Distinct patterns of language impairment in Down's syndrome and Williams syndrome: The case of syntactic chains , 2005, Journal of Neurolinguistics.

[63]  S. Crain Investigations In Universal Grammar , 1998 .

[64]  Dan Sperber,et al.  Modularity and Relevance , 2005 .

[65]  Stephen Crain,et al.  Navigating negative quantificational space , 2000 .

[66]  C A Morris,et al.  Natural history of Williams syndrome: physical characteristics. , 1988, The Journal of pediatrics.

[67]  Julien Musolino,et al.  Structure and Meaning in the Acquisition of Scope , 2006 .

[68]  Elissa L. Newport,et al.  Chapter 1 The Invention of Language by Children: Environmental and Biological Influences on the Acquisition of Language , 2005 .

[69]  J. Brock,et al.  Language abilities in Williams syndrome: A critical review , 2007, Development and Psychopathology.

[70]  M Davies,et al.  Language and Williams syndrome: how intact is "intact"? , 1997, Child development.

[71]  Sandy Lovie How the mind works , 1980, Nature.

[72]  A. Karmiloff-Smith Development itself is the key to understanding developmental disorders , 1998, Trends in Cognitive Sciences.

[73]  M. Ullman,et al.  A dissociation of lexical memory and grammar in Williams syndrome: Evidence from inflectional morphology , 1995 .

[74]  A. Clarke,et al.  Readings from mental deficiency : the changing outlook , 1978 .

[75]  Elizabeth Hughes,et al.  Proceedings of the 21th annual Boston University Conference on Language Development , 1997 .

[76]  Barbara Landau,et al.  Developmental Decline in the Acquisition of Spatial Language , 2010 .

[77]  Franck Ramus,et al.  Genes, brain, and cognition: A roadmap for the cognitive scientist , 2006, Cognition.

[78]  Annette Karmiloff-Smith,et al.  Pathways to Language , 2009 .

[79]  Complex grammar in Williams syndrome , 2007, Clinical linguistics & phonetics.

[80]  S. Crain,et al.  Structure dependence in grammar formation , 1987 .

[81]  C. Mervis,et al.  Language and communicative development in Williams syndrome. , 2007, Mental retardation and developmental disabilities research reviews.

[82]  Harald Clahsen,et al.  Syntax and morphology in Williams syndrome , 1998, Cognition.

[83]  Diane C. Lillo-Martin,et al.  An introduction to linguistic theory and language acquisition , 1999 .

[84]  Terry L. Jernigan,et al.  Williams syndrome: An unusual neuropsychological profile. , 1994 .

[85]  C. Norbury Language competence across populations: toward a definition of specific language impairment. , 2004 .

[87]  Stephen Crain,et al.  Why language acquisition is a snap , 2002 .

[88]  U. Bellugi,et al.  Neuropsychological, neurological, and neuroanatomical profile of Williams syndrome. , 2005, American journal of medical genetics. Supplement.

[89]  R. Jackendoff Patterns in the Mind , 1993 .

[90]  Dan Sperber,et al.  Modularity and relevance: How can a massively modular mind be flexible and context-sensitive? , 2004 .

[91]  Andrea Gualmini,et al.  Some knowledge children don't lack , 2004 .

[92]  Virginia Volterra,et al.  Memory Abilities in Children with Williams Syndrome , 1996, Cortex.

[93]  A. Karmiloff-Smith Atypical epigenesis. , 2007, Developmental science.

[94]  M. Piattelli-Palmarini Speaking of learning , 2001, Nature.

[95]  Ursula Bellugi,et al.  Interaction between language and cognition: Evidence from Williams syndrome. , 1996 .

[96]  Barbara Landau,et al.  Uncovering Knowledge of Core Syntactic and Semantic Principles in Individuals With Williams Syndrome , 2010, Language learning and development : the official journal of the Society for Language Development.

[97]  Ronald V. Schmelzer,et al.  Differential Abilities Scales , 2008 .

[98]  A. Karmiloff-Smith,et al.  Speaking of learning How do we acquire our marvellous facility for expressing ourselves in words ? , 2001 .

[99]  G. Marcus Can connectionism save constructivism? , 1998, Cognition.

[100]  U Bellugi,et al.  Cytoarchitectonic anomalies in a genetically based disorder: Williams syndrome. , 1994, Neuroreport.

[101]  S. Pinker So How Does the Mind Work , 2005 .

[102]  A. Zukowski Knowledge of constraints on compounding in children and adolescents with Williams syndrome. , 2005, Journal of speech, language, and hearing research : JSLHR.