Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet.

[1]  C B Wollheim,et al.  Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. , 1992, Endocrinology.

[2]  H. Vestergaard,et al.  Intact proinsulin and beta-cell function in lean and obese subjects with and without type 2 diabetes. , 1999, Diabetes care.

[3]  M. Magnuson,et al.  Analysis of the Cre‐mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas , 2000, Genesis.

[4]  C. Graff,et al.  Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes , 2000, Nature Genetics.

[5]  R. Unger,et al.  Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. , 2001, Diabetes.

[6]  Yuichiro Yamada,et al.  Prior exposure to high glucose augments depolarization-induced insulin release by mitigating the decline of ATP level in rat islets. , 2002, Endocrinology.

[7]  U. Boggi,et al.  Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. , 2002, Diabetes.

[8]  Robert A Rizza,et al.  Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. , 2003, Diabetes.

[9]  Robert A. Rizza,et al.  β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes , 2003, Diabetes.

[10]  Daniel J Klionsky,et al.  Development by self-digestion: molecular mechanisms and biological functions of autophagy. , 2004, Developmental cell.

[11]  R. DeFronzo Dysfunctional fat cells, lipotoxicity and type 2 diabetes , 2004, International journal of clinical practice. Supplement.

[12]  Takeshi Tokuhisa,et al.  The role of autophagy during the early neonatal starvation period , 2004, Nature.

[13]  Masaaki Komatsu,et al.  Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice , 2005, The Journal of cell biology.

[14]  Christopher J. Rhodes,et al.  Type 2 Diabetes-a Matter of ß-Cell Life and Death? , 2005, Science.

[15]  C. Rhodes Type 2 diabetes-a matter of beta-cell life and death? , 2005, Science.

[16]  Masaaki Komatsu,et al.  Loss of autophagy in the central nervous system causes neurodegeneration in mice , 2006, Nature.

[17]  C. Burant,et al.  Islet Microvasculature in Islet Hyperplasia and Failure in a Model of Type 2 Diabetes , 2006, Diabetes.

[18]  Hideyuki Okano,et al.  Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice , 2006, Nature.

[19]  K. Nakayama,et al.  Protein Kinase Cδ Plays a Non-redundant Role in Insulin Secretion in Pancreatic β Cells* , 2007, Journal of Biological Chemistry.

[20]  P. Codogno,et al.  Macroautophagy: Protector in the Diabetes Drama? , 2007, Autophagy.

[21]  Brad J Marsh,et al.  Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells. , 2007, Molecular endocrinology.

[22]  M. Vranic,et al.  Ubiquitinated-Protein Aggregates Form in Pancreatic β-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy , 2007, Diabetes.

[23]  Masaaki Komatsu,et al.  Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice , 2007, Cell.

[24]  Yasushi Matsumura,et al.  The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress , 2007, Nature Medicine.

[25]  K. Nakayama,et al.  Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. , 2007, The Journal of biological chemistry.

[26]  Guido Kroemer,et al.  Autophagy in the Pathogenesis of Disease , 2008, Cell.