Molecular Determinants for Activation of Human Ether-à-go-go-related Gene 1 Potassium Channels by 3-Nitro-N-(4-phenoxyphenyl) Benzamide
暂无分享,去创建一个
[1] Eduardo Perozo,et al. Structural mechanism of C-type inactivation in K+ channels , 2010, Nature.
[2] Benoît Roux,et al. Structural basis for the coupling between activation and inactivation gates in K+ channels , 2010, Nature.
[3] Gert Vriend,et al. Toward a Consensus Model of the hERG Potassium Channel , 2010, ChemMedChem.
[4] N. Castle,et al. Pharmacological Removal of Human Ether-à-go-go-Related Gene Potassium Channel Inactivation by 3-Nitro-N-(4-phenoxyphenyl) Benzamide (ICA-105574) , 2010, Molecular Pharmacology.
[5] F. Sachse,et al. PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance , 2009, Proceedings of the National Academy of Sciences.
[6] Andrew G. Leach,et al. Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. , 2009, Journal of medicinal chemistry.
[7] B. Zhorov,et al. Structural Model for Dihydropyridine Binding to L-type Calcium Channels* , 2009, The Journal of Biological Chemistry.
[8] Carsten Kutzner,et al. GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. , 2008, Journal of chemical theory and computation.
[9] F. Sachse,et al. Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator , 2007, Proceedings of the National Academy of Sciences.
[10] Ettore Novellino,et al. Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: model construction and docking calculations. , 2007, Journal of medicinal chemistry.
[11] W. Catterall,et al. Voltage-gated ion channels and gating modifier toxins. , 2007, Toxicon : official journal of the International Society on Toxinology.
[12] M. Sanguinetti,et al. hERG potassium channels and cardiac arrhythmia , 2006, Nature.
[13] Oscar Casis,et al. Mechanism of Action of a Novel Human ether-a-go-go-Related Gene Channel Activator , 2006, Molecular Pharmacology.
[14] U. Ravens,et al. Activation of Human ether-a-go-go-Related Gene Potassium Channels by the Diphenylurea 1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) , 2006, Molecular Pharmacology.
[15] Jun Zhou,et al. Novel Potent Human Ether-à-Go-Go-Related Gene (hERG) Potassium Channel Enhancers and Their in Vitro Antiarrhythmic Activity , 2005, Molecular Pharmacology.
[16] Jiesheng Kang,et al. Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K+ Channel , 2005, Molecular Pharmacology.
[17] Michael C Sanguinetti,et al. Predicting drug-hERG channel interactions that cause acquired long QT syndrome. , 2005, Trends in pharmacological sciences.
[18] Gregory W. Kauffman,et al. Physicochemical Features of the hERG Channel Drug Binding Site* , 2004, Journal of Biological Chemistry.
[19] J. Brugada,et al. Sudden Death Associated With Short-QT Syndrome Linked to Mutations in HERG , 2003, Circulation.
[20] Michael C Sanguinetti,et al. Gating currents associated with intramembrane charge displacement in HERG potassium channels , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[21] Jules C Hancox,et al. Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes. , 2002, Journal of pharmacological and toxicological methods.
[22] Jun Chen,et al. A structural basis for drug-induced long QT syndrome. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[23] W. Allan,et al. Long QT Syndrome , 1998, Pediatrics.
[24] A. Brown,et al. Molecular determinants of dofetilide block of HERG K+ channels. , 1998, Circulation research.
[25] Berk Hess,et al. LINCS: A linear constraint solver for molecular simulations , 1997, J. Comput. Chem..
[26] O. Berger,et al. Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature. , 1997, Biophysical journal.
[27] M. Sanguinetti,et al. Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes. , 1997, The American journal of physiology.
[28] W. L. Jorgensen,et al. Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids , 1996 .
[29] S. Heinemann,et al. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. , 1996, The Journal of physiology.
[30] N. Klugbauer,et al. The IVS6 segment of the L‐type calcium channel is critical for the action of dihydropyridines and phenylalkylamines. , 1996, The EMBO journal.
[31] Gary Yellen,et al. The inward rectification mechanism of the HERG cardiac potassium channel , 1996, Nature.
[32] G. Robertson,et al. HERG, a human inward rectifier in the voltage-gated potassium channel family. , 1995, Science.
[33] M. Sanguinetti,et al. A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel , 1995, Cell.
[34] E. Green,et al. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome , 1995, Cell.
[35] H. Lester,et al. Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes , 1994, Pflügers Archiv.
[36] T. Darden,et al. Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems , 1993 .
[37] S. Nosé. A unified formulation of the constant temperature molecular dynamics methods , 1984 .
[38] W. L. Jorgensen,et al. Comparison of simple potential functions for simulating liquid water , 1983 .
[39] M. Parrinello,et al. Polymorphic transitions in single crystals: A new molecular dynamics method , 1981 .
[40] B. Sakmann,et al. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches , 1981, Pflügers Archiv.
[41] F. Bezanilla,et al. Cut-open oocyte voltage-clamp technique. , 1998, Methods in enzymology.
[42] F Bezanilla,et al. Gating currents. , 1998, Methods in enzymology.
[43] Francisco Bezanilla,et al. [19] Gating currents , 1998 .
[44] W. Catterall,et al. Molecular determinants of drug binding and action on L-type calcium channels. , 1997, Annual review of pharmacology and toxicology.
[45] R. Glen,et al. Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation. , 1995, Journal of molecular biology.
[46] W. Stühmer,et al. Electrophysiological recording from Xenopus oocytes. , 1992, Methods in enzymology.
[47] A. L. Goldin. Expression of ion channels by injection of mRNA into Xenopus oocytes. , 1991, Methods in cell biology.