Pediatric Pulmonology

Correspondence Arwen Jackson, Department of Pediatrics, University of Colorado School of Medicine, 13123 E 16th Ave, Box 745, Aurora, CO 80045. Email: arwen.jackson@childrenscolorado.org Abstract Objectives: Children with Down syndrome (DS) have a high risk of dysphagia and the pediatric pulmonologist may be involved in diagnosis and management. The objective of this study is to evaluate the associations between age, dysphagia, and medical comorbidities in young children with DS. We hypothesized that swallow study findings are more likely to change in younger infants and that medical comorbidities may be associated with dysphagia. Study design: Results of videofluoroscopic swallow studies (VFSS) and fiberoptic endoscopic evaluation of swallowing (FEES) from 2010 to 2016 were collected retrospectively in children with DS with initial swallow study at less than 12 months of age. Results were analyzed for findings and change based on age at initial study, reason for referral, and medical comorbidities. Results: One hundred eleven infants with 247 VFSS and 14 FEES were included. Deep laryngeal penetration and/or aspiration were found in 31.9% of infants less than 6 months and 51.3% of infants 6 to 12 months. Children with initial swallow study performed at greater than or equal to 6 months of age were more likely (80.0%) to have unchanged findings on follow‐up study compared to children imaged at less than 6 months (35.3%). Laryngomalacia, pulmonary hypertension, pneumonia, and congenital cardiac disease were associated with dysphagia. Conclusion: We confirmed that dysphagia is common in infants with DS and comorbidities and provided preliminary evidence that swallow study findings may be more likely to change in children tested under 6 months of age. Providers should consider that results for instrumental swallow studies may change, particularly if the test was completed on a young infant.

[1]  R. Rahbar,et al.  Feeding Interventions Are Associated With Improved Outcomes in Children With Laryngeal Penetration , 2019, Journal of pediatric gastroenterology and nutrition.

[2]  M. Bull,et al.  Clinical identification of feeding and swallowing disorders in 0–6 month old infants with Down syndrome , 2018, American journal of medical genetics. Part A.

[3]  M. Ndlovu Sleep-disordered breathing and ventilatory support in children with Down syndrome , 2018, African Journal of Thoracic and Critical Care Medicine.

[4]  K. Walsh,et al.  Velopharyngeal incompetence: role in paediatric swallowing deficits , 2018, Current opinion in otolaryngology & head and neck surgery.

[5]  D. Ivy,et al.  Clinical Characteristics and Risk Factors for Developing Pulmonary Hypertension in Children with Down Syndrome , 2018, The Journal of pediatrics.

[6]  Bridget M. Harrington,et al.  Pediatric Swallowing Function in the Presence of Laryngeal Cleft and Laryngomalacia: a Review of the Literature , 2018, Current Otorhinolaryngology Reports.

[7]  Carly E. A. Barbon,et al.  Understanding the Viscosity of Liquids used in Infant Dysphagia Management , 2016, Dysphagia.

[8]  Arwen Jackson,et al.  Clinical Characteristics of Dysphagia in Children with Down Syndrome , 2016, Dysphagia.

[9]  R. Deterding,et al.  Multidisciplinary care of children with repaired esophageal atresia and tracheoesophageal fistula , 2016, Pediatric pulmonology.

[10]  P. Dodrill,et al.  Swallowing dysfunction among patients with laryngeal cleft: More than just aspiration? , 2016, International journal of pediatric otorhinolaryngology.

[11]  H. Vyas,et al.  An overview of respiratory problems in children with Down's syndrome , 2013, Archives of Disease in Childhood.

[12]  Walter Huda,et al.  Preliminary Investigation of the Effect of Pulse Rate on Judgments of Swallowing Impairment and Treatment Recommendations , 2013, Dysphagia.

[13]  G. Richter,et al.  Pharyngeal Dysphagia in Children with Down Syndrome , 2012, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[14]  G. McPhail,et al.  Bronchiectasis in chronic pulmonary aspiration: Risk factors and clinical implications , 2012, Pediatric pulmonology.

[15]  M. Gosa,et al.  Dysphagia and aspiration in children , 2012, Pediatric pulmonology.

[16]  Young-mee Ahn,et al.  Assessment of Primitive Reflexes in High-risk Newborns , 2011, Journal of clinical medicine research.

[17]  D. Craven,et al.  Pulmonary complications of Down syndrome during childhood. , 2011, The Journal of pediatrics.

[18]  S. Langton-Hewer,et al.  Management of pulmonary hypertension in Down syndrome , 2011, European Journal of Pediatrics.

[19]  S. Barlow Central pattern generation involved in oral and respiratory control for feeding in the term infant , 2009, Current opinion in otolaryngology & head and neck surgery.

[20]  P. Harris,et al.  Research electronic data capture (REDCap) - A metadata-driven methodology and workflow process for providing translational research informatics support , 2009, J. Biomed. Informatics.

[21]  Rafat Hussain,et al.  The four ages of Down syndrome. , 2007, European journal of public health.

[22]  Richard D. Jones,et al.  The First Year of Human Life: Coordinating Respiration and Nutritive Swallowing , 2007, Dysphagia.

[23]  N. Virji-Babul,et al.  Children with Down Syndrome , 2006 .

[24]  I. Sánchez,et al.  Airway anomalies in children with Down syndrome: endoscopic findings , 2003, Pediatric pulmonology.

[25]  P. Seddon,et al.  Respiratory problems in children with neurological impairment , 2003, Archives of disease in childhood.

[26]  S. Rasmussen,et al.  Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study , 2002, The Lancet.

[27]  J. Arvedson,et al.  Pediatric Swallowing and Feeding: Assessment and Management , 2001 .

[28]  D. Lieberman,et al.  Ontogeny of postnatal hyoid and larynx descent in humans. , 2001, Archives of oral biology.

[29]  B. Friedman,et al.  SWALLOW FUNCTION IN CHILDREN WITH DOWN SYNDROME: A RETROSPECTIVE STUDY , 1996, Developmental medicine and child neurology.

[30]  M. Digilio,et al.  Health Supervision for Children With Down Syndrome , 1994, Pediatric Clinical Practice Guidelines & Policies.

[31]  B. Hagberg,et al.  CLINICAL CHARACTERISTICS , 1972 .

[32]  F. Hickey,et al.  Pediatric Comorbidities and Medical Complications Identified in Children with Down Syndrome , 2017 .

[33]  M. Cohen,et al.  Can we use pulsed fluoroscopy to decrease the radiation dose during video fluoroscopic feeding studies in children? , 2009, Clinical radiology.

[34]  Amy L. Delaney,et al.  Development of swallowing and feeding: prenatal through first year of life. , 2008, Developmental disabilities research reviews.

[35]  J. Frazier,et al.  Deep Laryngeal Penetration as a Predictor of Aspiration , 2000, Dysphagia.

[36]  S. Langmore Endoscopic Evaluation and Treatment of Swallowing Disorders , 2000 .

[37]  Jo Shapiro,et al.  Evaluation and treatment of swallowing disorders , 1992, Comprehensive therapy.