Relationship between oxidative stress and cognitive impairment in the elderly of rural vs. urban communities.

Psychological stress and environmental pollution are frequently associated to urban environment and oxidative stress (OxS). Likewise, OxS is a risk factor for cognitive impairment (CI) in the elderly. Therefore, we hypothesized that the prevalence of CI in subjects of the urban area could be higher than in those of the rural area, and linked to higher OxS. The aim of the study was to determine the relationship between OxS and CI in elderly individuals from rural and urban settings in Mexico. Plasmatic TBARS, plasma total antioxidant status, and the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured in 104 urban and 85 rural elderly individuals. Cognitive functions were evaluated through the Mini Mental State Examination. We found a greater proportion of subjects with OxS and CI in urban than in rural areas (25% vs. 9%), with an odds ratio of 5.67 (CI95% 1.14-38.02, p < 0.05). Our findings suggest that the elderly in urban areas have more OxS and a higher risk of developing CI compared with elderly individuals in a rural environment.

[1]  G. Schulze.  Sleep protects excitatory cortical circuits against oxidative damage. , 2004, Medical hypotheses.

[2]  F. Schmitt,et al.  Evidence of increased oxidative damage in subjects with mild cognitive impairment , 2005, Neurology.

[3]  V. Núñez,et al.  Propuesta de un constructo para evaluar integralmente el estrés oxidativo , 2004 .

[4]  J. Lindeboom,et al.  Neuropsychology of cognitive ageing, minimal cognitive impairment, Alzheimer's disease, and vascular cognitive impairment. , 2004, European journal of pharmacology.

[5]  V. M. Mendoza-Núñez,et al.  Efficient antioxidant capacity against lipid peroxide levels in healthy elderly of Mexico City. , 2005, Environmental research.

[6]  P. Fürst,et al.  Improved analysis of malondialdehyde in human body fluids. , 1996, Free radical biology & medicine.

[7]  R. Thomson,et al.  A systematic review of cognitive decline in the general elderly population , 2003, International journal of geriatric psychiatry.

[8]  G. Perry,et al.  How important is oxidative damage? Lessons from Alzheimer's disease. , 2000, Free radical biology & medicine.

[9]  R A Boileau,et al.  The physical activity scale for the elderly (PASE): evidence for validity. , 1999, Journal of clinical epidemiology.

[10]  A. Barrocas,et al.  Nutrition assessment practical approaches. , 1995, Clinics in geriatric medicine.

[11]  Ömer Akyol,et al.  The indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients The possible role of oxidant/antioxidant imbalance , 2002, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[12]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[13]  H. Christensen,et al.  Education, Activity, Health, Blood Pressure and Apolipoprotein E as Predictors of Cognitive Change in Old Age: A Review , 2000, Gerontology.

[14]  W R Markesbery,et al.  Oxidative stress hypothesis in Alzheimer's disease. , 1997, Free radical biology & medicine.

[15]  L. Poon,et al.  The Influence of Rural/Urban Residence on Health in the Oldest-Old , 1994, International journal of aging & human development.

[16]  M. Altamirano-Lozano,et al.  Total antioxidant levels, gender, and age as risk factors for DNA damage in lymphocytes of the elderly , 2001, Mechanisms of Ageing and Development.

[17]  N. Delibaş,et al.  Clinical importance of erythrocyte malondialdehyde levels as a marker for cognitive deterioration in patients with dementia of Alzheimer type: a repeated study in 5-year interval. , 2002, Clinical biochemistry.

[18]  A. Stuck,et al.  Risk factors for functional status decline in community-living elderly people: a systematic literature review. , 1999, Social science & medicine.

[19]  P. Garry,et al.  Relationships Between Nutritional Markers and the Mini‐Nutritional Assessment in 155 Older Persons , 2000, Journal of the American Geriatrics Society.

[20]  N. Wacher,et al.  Changes in human serum antioxidant capacity and peroxidation after four months of exposure to air pollutants. , 1997, Archives of medical research.

[21]  K. Fukui,et al.  Impairment of Learning and Memory in Rats Caused by Oxidative Stress and Aging, and Changes in Antioxidative Defense Systems , 2001, Annals of the New York Academy of Sciences.

[22]  J. Jolles,et al.  How ageing and social factors affect memory. , 1999, Age and ageing.

[23]  K. Kawano,et al.  A novel in-frame deletion mutation in a case of lactate dehydrogenase (LD) H subunit deficiency showing an atypical LD isoenzyme pattern in serum and erythrocytes. , 1999, Clinical biochemistry.

[24]  L. Thal,et al.  Cholesterol, oxidative stress, and Alzheimer's disease: expanding the horizons of pathogenesis. , 2002, Free radical biology & medicine.

[25]  P. Mecocci,et al.  Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease , 2003, Neurobiology of Aging.