High frequency of pertussis in older children and adolescents with prolonged cough in Turkey.

This study aimed to determine the frequency of B. pertussis infection among Turkish children with prolonged cough. Nasopharyngeal specimens were collected from 7-18 year old children, presenting with prolonged cough of two to four weeks' duration. Specimens were examined for B. pertussis by PCR. Of 101 children with prolonged cough, 20 (19.8%) had a positive PCR testing for B. pertussis. Children who were vaccinated ≥5 years previously had a 6.13-fold higher risk of PCR-confirmed pertussis than those who were vaccinated < 5 years before. The classic symptoms of pertussis (paroxysmal cough, whooping and post-tussive vomiting) were seen in 30%, 15% and 25% of the patients with positive PCR, respectively; 55% of them had only a prolonged cough without any classic symptoms. Pertussis is common among Turkish children with prolonged cough, even after implementation of a fifth dose of pertussis vaccination and despite high vaccination coverage.

[1]  D. Mant,et al.  Whooping cough in school age children presenting with persistent cough in UK primary care after introduction of the preschool pertussis booster vaccination: prospective cohort study , 2014, BMJ : British Medical Journal.

[2]  Eleanor A. Smith,et al.  Pertussis: a reemerging infection. , 2013, American family physician.

[3]  田村 大輔,et al.  Centers for Disease Control and Prevention(CDC)での生活 , 2013 .

[4]  C. Kenyon,et al.  Waning Immunity to Pertussis Following 5 Doses of DTaP , 2013, Pediatrics.

[5]  S. Armin,et al.  Frequency of pertussis in iranian school-age children , 2013, Journal of Pediatric Infectious Diseases.

[6]  V. Sintchenko,et al.  The "how" of polymerase chain reaction testing for Bordetella pertussis depends on the "why". , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[7]  Bruce Fireman,et al.  Waning protection after fifth dose of acellular pertussis vaccine in children. , 2012, The New England journal of medicine.

[8]  D. Greenberg,et al.  Clinical Definitions of Pertussis: Summary of a Global Pertussis Initiative Roundtable Meeting, February 2011 , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[9]  T. Clark,et al.  Pertussis Pseudo-outbreak Linked to Specimens Contaminated by Bordetella pertussis DNA From Clinic Surfaces , 2012, Pediatrics.

[10]  N. Kennerknecht,et al.  Comparison of commercially available immunoblot assays measuring IgG and IgA antibodies to Bordetella pertussis antigens , 2011, European Journal of Clinical Microbiology & Infectious Diseases.

[11]  A. Shamshiri,et al.  Sensitivity and specificity of the World Health Organization pertussis clinical case definition. , 2010, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[12]  G. Berbers,et al.  What to do and what not to do in serological diagnosis of pertussis: recommendations from EU reference laboratories , 2010, European Journal of Clinical Microbiology & Infectious Diseases.

[13]  M. Tondella,et al.  Development and Analytical Validation of an Immunoassay for Quantifying Serum Anti-Pertussis Toxin Antibodies Resulting from Bordetella pertussis Infection , 2009, Clinical and Vaccine Immunology.

[14]  E. Bingen,et al.  Real-Time PCR Measurement of Persistence of Bordetella pertussis DNA in Nasopharyngeal Secretions during Antibiotic Treatment of Young Children with Pertussis , 2008, Journal of Clinical Microbiology.

[15]  S. Pelton,et al.  Frequency of pertussis in children with prolongued cough , 2008, Scandinavian journal of infectious diseases.

[16]  D. Dilli,et al.  Recent findings on pertussis epidemiology in Turkey , 2008, European Journal of Clinical Microbiology & Infectious Diseases.

[17]  M. Nissen,et al.  Bordetella pertussis PCR positivity, following onset of illness in children under 5 years of age. , 2007, Communicable diseases intelligence quarterly report.

[18]  S. Ozkan,et al.  High incidence of Pertussis among schoolchildren with prolonged cough in Turkey. , 2007, The Tohoku journal of experimental medicine.

[19]  H. Kessler,et al.  Detection and Differentiation of Bordetella spp. by Real-Time PCR , 2006, Journal of Clinical Microbiology.

[20]  E. Bingen,et al.  Treatment Failure of Nosocomial Pertussis Infection in a Very-Low-Birth-Weight Neonate , 2006, Journal of Clinical Microbiology.

[21]  V. Caro,et al.  Nucleic Acid Amplification Tests for Diagnosis of Bordetella Infections , 2005, Journal of Clinical Microbiology.

[22]  J. Cherry Pertussis Vaccines for Adolescents and Adults , 2005, Pediatrics.

[23]  J. Mertsola,et al.  Defining Pertussis Epidemiology: Clinical, Microbiologic and Serologic Perspectives , 2005, The Pediatric infectious disease journal.

[24]  J. Jensen,et al.  Comparison of culture and PCR for detection of Bordetella pertussis and Bordetella parapertussis under routine laboratory conditions. , 2004, Journal of medical microbiology.

[25]  A. Flahault,et al.  Is pertussis being considered as a cause of persistent cough among adults? , 2002, European Journal of Epidemiology.

[26]  P. Roux,et al.  Étiologie de la toux chronique de l'enfant : analyse de 100 dossiers , 2001 .

[27]  I. Pin,et al.  [Etiology of chronic cough in children: analysis of 100 cases]. , 2001, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[28]  W. Yih,et al.  The increasing incidence of pertussis in Massachusetts adolescents and adults, 1989-1998. , 2000, The Journal of infectious diseases.

[29]  J. Cherry,et al.  Clinical Validation of a Polymerase Chain Reaction Assay for the Diagnosis of Pertussis by Comparison With Serology, Culture, and Symptoms During a Large Pertussis Vaccine Efficacy Trial , 2000, Pediatrics.

[30]  C. Welinder-Olsson,et al.  Evaluation of PCR for Diagnosis of Bordetella pertussis and Bordetella parapertussisInfections , 1998, Journal of Clinical Microbiology.

[31]  J. Liese,et al.  Polymerase chain reaction (PCR) compared with conventional identification in culture for detection of Bordetella pertussis in 7153 children. , 1997, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[32]  N. M. Sirota,et al.  Outbreak of pertussis in a fully immunized adolescent and adult population. , 1996, Archives of pediatrics & adolescent medicine.