On the Measurement of Electrical Impedance Spectroscopy (EIS) of the Human Head.

We are introducing a system for Electrical Impedance Spectroscopy (EIS) measurements for future use in Neurological Intensive Care Unit (NICU) settings. The system consists mostly of commercially available components and the software was developed in Labview (National Instruments). The system is based on the principle that acute hemorrhagic stroke may produce detectable changes in the impedance spectrum measured on the subject's scalp due to parenchimal local increases of blood volume. EIS measurements were performed on four healthy control subjects to establish a baseline for a real time stroke detector. Measurements were performed using white noise currents in the 0-50 kHz frequency band using ten shielded electrodes placed on a subject's scalp, with electrical potentials measured with a large-dynamic range for increased EIS accuracy. EIS measurements yielded highly symmetrical impedance spectra, which was only obtainable using the proposed continuos spectral electrical impedance estimation.

[1]  R Bragós,et al.  Measurement errors in multifrequency bioelectrical impedance analyzers with and without impedance electrode mismatch , 2009, Physiological measurement.

[2]  W. Graham Richards,et al.  Art of electronics , 1983, Nature.

[3]  R. W. Lau,et al.  The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. , 1996, Physics in medicine and biology.

[4]  R. Sadleir,et al.  Predicted current densities in the brain during transcranial electrical stimulation , 2006, Clinical Neurophysiology.

[5]  D. Isaacson Distinguishability of Conductivities by Electric Current Computed Tomography , 1986, IEEE Transactions on Medical Imaging.

[6]  R H Bayford,et al.  A comparison of headnet electrode arrays for electrical impedance tomography of the human head. , 2003, Physiological measurement.

[7]  T. M. Nahir,et al.  Impedance Spectroscopy: Theory, Experiment, and Applications, 2nd ed Edited by Evgenij Barsoukov (Texas Instruments Inc.) and J. Ross Macdonald (University of North Carolina, Chapel Hill). John Wiley & Sons, Inc.: Hoboken, NJ. 2005. xvii + 596 pp. $125.00. ISBN 0471-64749-7. , 2005 .

[8]  A Korjenevsky,et al.  A 3D electrical impedance tomography (EIT) system for breast cancer detection. , 2001, Physiological measurement.

[9]  Boris Rubinsky,et al.  Electrical impedance tomography of cell viability in tissue with application to cryosurgery. , 2004, Journal of biomechanical engineering.

[10]  T. Yamamoto,et al.  Non-linear electrical properties of skin in the low frequency range , 1981, Medical and Biological Engineering and Computing.

[11]  Asghar Keshtkar,et al.  Modeled Current Distribution Inside the Normal and Malignant Human Urothelium Using Finite Element Analysis , 2008, IEEE Transactions on Biomedical Engineering.

[12]  J. Bronzwaer,et al.  Determination of stroke volume by means of electrical impedance tomography. , 2000, Physiological measurement.

[13]  Michael A. Saunders,et al.  LSQR: An Algorithm for Sparse Linear Equations and Sparse Least Squares , 1982, TOMS.

[14]  D. Corfield,et al.  Microwave Tomography for Brain Imaging: Feasibility Assessment for Stroke Detection , 2008 .

[15]  S. Iwaki,et al.  The Shape of Electrical Impedance Spectroscopy (EIS) is altered in Stroke Patients , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[16]  B H Brown,et al.  A comparison of ventilatory and cardiac related changes in EIT images of normal human lungs and of lungs with pulmonary emboli. , 1994, Physiological measurement.

[17]  J. Patrick Reilly,et al.  Applied Bioelectricity: From Electrical Stimulation to Electropathology , 1998 .

[18]  M M Gebhard,et al.  The complex dielectric spectrum of heart tissue during ischemia. , 2002, Bioelectrochemistry.

[19]  Naven Duggal,et al.  Electrical impedance myography in the assessment of disuse atrophy. , 2009, Archives of physical medicine and rehabilitation.

[20]  P. Welch The use of fast Fourier transform for the estimation of power spectra: A method based on time averaging over short, modified periodograms , 1967 .

[21]  Robert A. Peura,et al.  Algorithm for tissue ischemia estimation based on electrical impedance spectroscopy , 2003, IEEE Transactions on Biomedical Engineering.

[22]  Keith D. Paulsen,et al.  On optimal current patterns for electrical impedance tomography , 2005, IEEE Transactions on Biomedical Engineering.

[23]  A. Hansen,et al.  Brain extracellular space during spreading depression and ischemia. , 1980, Acta physiologica Scandinavica.

[24]  E. Barsoukov,et al.  Impedance spectroscopy : theory, experiment, and applications , 2005 .

[25]  Michal M. Okoniewski,et al.  Adaptive Mesh Refinement Techniques for 3-D Skin Electrode Modeling , 2010, IEEE Transactions on Biomedical Engineering.

[26]  K. Furie,et al.  Treating intracerebral hemorrhage effectively in the ICU. The key steps: provide supportive care and determine the cause. , 1995, The Journal of critical illness.

[27]  R. Anderson,et al.  Using electrical impedance spectroscopy to detect water in planetary regoliths. , 2008, Astrobiology.

[28]  Alexander S Ross,et al.  Current source design for electrical impedance tomography. , 2003, Physiological measurement.

[29]  Giorgio Bonmassar,et al.  On the effect of resistive EEG electrodes and leads during 7 T MRI: simulation and temperature measurement studies. , 2006, Magnetic resonance imaging.

[30]  D. Regan Human brain electrophysiology: Evoked potentials and evoked magnetic fields in science and medicine , 1989 .

[31]  R. W. Lau,et al.  The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. , 1996, Physics in medicine and biology.

[32]  Eng H. Lo,et al.  Neurological diseases: Mechanisms, challenges and opportunities in stroke , 2003, Nature Reviews Neuroscience.

[33]  Gregory Boverman,et al.  Methods for Compensating for Variable Electrode Contact in EIT , 2009, IEEE Transactions on Biomedical Engineering.

[35]  R H Bayford,et al.  Electrical impedance tomography spectroscopy (EITS) for human head imaging. , 2003, Physiological measurement.

[36]  D S Holder,et al.  A comparison of two EIT systems suitable for imaging impedance changes in epilepsy , 2009, Physiological measurement.

[37]  C Gabriel,et al.  The dielectric properties of biological tissues: I. Literature survey. , 1996, Physics in medicine and biology.

[38]  Pedro Bertemes-Filho,et al.  Frequency-domain reconstruction of signals in electrical bioimpedance spectroscopy , 2009, Medical & Biological Engineering & Computing.