Interstitial fluid pressure due to externally applied force in breast tissue

Manipulation of Interstitial Fluid Pressure (IFP) has clinical potential when used in conjunction with near infrared spectroscopy for detection and characterization of breast cancer. IFP is a function of blood chemistry, vessel microanatomy, mechanical properties of the tissue, tissue geometry, and external force. IFP has been demonstrated higher in tumors than normal tissue, and it has been suggested that increased IFP can lead to changes in near infrared absorbing and scattering coefficients. While it is known that external forces can increase IFP, the relationship of force to IFP in a viscoelastic, hyperelastic solid such as tissue is complex. Fluid pressure measurements were taken in gelatin phantoms of equivalent elastic modulus to adipose and glandular tissues of the breast using a WaveMap pressure transducer. 3D pressure maps were obtained for the volumes of the phantoms with an externally applied force of 10mmHg, demonstrating the contribution of shear stress, non-linear mechanical properties, and tissue geometry. Linear elastic computational models were formulated for breast tissue with and without an inclusion of tumor-like mechanical properties. Comparison of experimental and computational model data indicates that light external pressure can lead to heterogeneous IFP distribution within tissues and increased IFP gradients around tumor-like inclusions.

[1]  Gordon Je.  Biomechanics: the last stronghold of vitalism. , 1980 .

[2]  F. White.  Viscous Fluid Flow , 1974 .

[3]  G V Cochran,et al.  Subcutaneous interstitial fluid pressure during external loading. , 1981, The American journal of physiology.

[4]  Brian W Pogue,et al.  In vivo near-infrared spectral detection of pressure-induced changes in breast tissue. , 2003, Optics letters.

[5]  Dimitris N. Metaxas,et al.  A deformable finite element model of the breast for predicting mechanical deformations under external perturbations. , 2001, Academic radiology.

[6]  Rui Yang,et al.  Elevated Physiologic Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma , 2005, Clinical Cancer Research.

[7]  R K Jain,et al.  Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. , 1992, Cancer research.

[8]  J. Greenleaf,et al.  Selected methods for imaging elastic properties of biological tissues. , 2003, Annual review of biomedical engineering.

[9]  Assad A. Oberai,et al.  Coupling between elastic strain and interstitial fluid flow: Ramifications for poroelastic imaging , 2006 .

[10]  Lynne E. Bilston,et al.  The Effect of Perfusion on Soft Tissue Mechanical Properties: A Computational Model , 2002, Computer methods in biomechanics and biomedical engineering.

[11]  R. Reed,et al.  Fluid pressure in human dermal fibroblast aggregates measured with micropipettes. , 2003, American journal of physiology. Cell physiology.

[12]  T. Krouskop,et al.  Elastic Moduli of Breast and Prostate Tissues under Compression , 1998, Ultrasonic imaging.

[13]  David A Boas,et al.  Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain function. , 2005, Applied optics.

[14]  A.R. Skovoroda,et al.  Measuring the nonlinear elastic properties of tissue-like phantoms , 2004, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[15]  A C Guyton,et al.  Interstitial Fluid Pressure , 1968, Circulation research.

[16]  Yaling Pei,et al.  Spatial deconvolution technique to improve the accuracy of reconstructed three-dimensional diffuse optical tomographic images. , 2005, Applied optics.

[17]  K Messmer,et al.  Interstitial hypertension in head and neck tumors in patients: correlation with tumor size. , 1992, Cancer research.

[18]  M W Vannier,et al.  Analytic modeling of breast elastography. , 2003, Medical physics.