DETECTION OF EARLY MYOCARDIAL INFARCTION DURING POSTMORTEM BY FLUORESCENT MICROSCOPIC EVALUATION

Present clinical management of the patients sustaining traumatic injuries and thermal burns has resulted in their longer survival, but the clinical and pathological effects of these traumatic injuries over the myocardium have been largely neglected. It is speculated that certain factors like the inflammatory and degenerative lesions of heart, prolonged clinical course and the subsequent stress and strain may play role in hastening the death. In the present study, hospitalized cases of traumatic injuries and thermal burns brought for medico-legal autopsy were examined, with the purpose to find out the incidence, its significance and the extent of the myocardial lesions caused due to stress & strain following trauma. The myocardium of each case was examined morphologically, and by using fluorescence microscope utilizing the Acridine Orange (AO) staining method, to detect the presence of the myocardial lesions developing in the myocardium due to the effects of stress and strain following trauma.

[1]  A. Kher,et al.  SEX DIFFERENCES IN THE MYOCARDIAL INFLAMMATORY RESPONSE TO ACUTE INJURY , 2005, Shock.

[2]  S. Homma,et al.  Editorial comment--myocardial damage in patients with subarachnoid hemorrhage. , 2004, Stroke.

[3]  B. Drew,et al.  Predictors of Neurocardiogenic Injury After Subarachnoid Hemorrhage , 2004, Stroke.

[4]  I. Damjanov.  Handbook of Autopsy Practice, 3rd Edition , 2003 .

[5]  B. Foëx.  Systemic responses to trauma. , 1999, British medical bulletin.

[6]  K. Yoshida,et al.  Myocardial lesions induced after trauma and treatment. , 1992, Forensic science international.

[7]  E. Villanueva,et al.  Comparison of different techniques for the postmortem diagnosis of myocardial infarction. , 1988, Forensic science international.

[8]  P. Boor,et al.  A simple planimetric method for determination of left ventricular mass and necrotic myocardial mass in postmortem hearts. , 1977, American journal of clinical pathology.

[9]  N. Ratliff,et al.  The Heart in Shock , 1974, Circulation research.

[10]  D. Hackel,et al.  Comparative study of myocardial lesions in hemorrhagic shock. , 1973, Laboratory investigation; a journal of technical methods and pathology.

[11]  R. Connor.  Fuchsinophilic degeneration of myocardium in patients with intracranial lesions. , 1970, British heart journal.

[12]  K. Hammermeister,et al.  QRS changes, pulmonary edema, and myocardial necrosis associated with subarachnoid hemorrhage. , 1969, American heart journal.

[13]  R. Connor.  Heart Damage Associated with Intracranial Lesions , 1968, British medical journal.

[14]  V. N. Sharma,et al.  Restraint stress as it influences the myocardium of rat. , 1966, The Indian journal of medical research.

[15]  B. Knight.  The Post-Mortem Demonstration of Early Myocardial Infarction , 1965, Medicine, science, and the law.

[16]  H. Barber.  THE EFFECTS OF TRAUMA, DIRECT AND INDIRECT, ON THE HEART , 1944 .