Assessing the (a)symmetry of concentration-effect curves: empirical versus mechanistic models.

[1]  P. Strange,et al.  Dopamine D2 Receptor Dimer Formation , 2001, The Journal of Biological Chemistry.

[2]  Michel Bouvier,et al.  Oligomerization of G-protein-coupled transmitter receptors , 2001, Nature Reviews Neuroscience.

[3]  G. Milligan,et al.  Oligomerisation of G-protein-coupled receptors. , 2001, Journal of cell science.

[4]  J. Tallman.  Dimerization of G-Protein-Coupled Receptors: Implications for Drug Design and Signaling , 2000, Neuropsychopharmacology.

[5]  U. Gether.  Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. , 2000, Endocrine reviews.

[6]  M. Lew,et al.  Beyond Eyeballing: Fitting Models to Experimental Data , 2000, Critical reviews in biochemistry and molecular biology.

[7]  P. Strange.  G-protein coupled receptors: conformations and states. , 1999, Biochemical pharmacology.

[8]  T. Feuerstein,et al.  Mathematical analysis of the control of neurotransmitter release by presynaptic receptors as a supplement to experimental data , 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

[9]  J. Giraldo,et al.  Modelling the changes due to the endothelium and hypertension in the alpha-adrenoreceptor-mediated responses of rat aorta. , 1999, Journal of autonomic pharmacology.

[10]  P. H. van der Graaf,et al.  Analysis of asymmetry of agonist concentration-effect curves. , 1999, Journal of pharmacological and toxicological methods.

[11]  D. Colquhoun.  Pharmacologic Analysis of Drug–Receptor Interaction (3rd edn) , 1998 .

[12]  D. Colquhoun,et al.  Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors , 1998, British journal of pharmacology.

[13]  T. Feuerstein,et al.  Agneter et al. reply , 1998 .

[14]  J. Giraldo.  The slope parameter and the receptor reserve. , 1998, Trends in pharmacological sciences.

[15]  T. Lewis,et al.  Properties of human glycine receptors containing the hyperekplexia mutation α1(K276E), expressed in Xenopus oocytes , 1998, The Journal of physiology.

[16]  T. Kenakin,et al.  Differences between natural and recombinant G protein-coupled receptor systems with varying receptor/G protein stoichiometry. , 1997, Trends in pharmacological sciences.

[17]  P. Leff,et al.  A three-state receptor model of agonist action. , 1997, Trends in pharmacological sciences.

[18]  L. Pardo,et al.  The effect of the molecular mechanism of G protein-coupled receptor activation on the process of signal transduction. , 1997, European journal of pharmacology.

[19]  T. Feuerstein,et al.  The slope parameter of concentration-response curves used as a touchstone for the existence of spare receptors , 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

[20]  J. Giraldo,et al.  Use of the operational model of agonism and [3H]prazosin binding to assess altered responsiveness of α1-adrenoceptors in the vas deferens of spontaneously hypertensive rat , 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

[21]  J. W. Wells,et al.  Cardiac muscarinic receptors. Cooperativity as the basis for multiple states of affinity. , 1997, Biochemistry.

[22]  J. W. Wells,et al.  Cardiac muscarinic receptors. Relationship between the G protein and multiple states of affinity. , 1997, Biochemistry.

[23]  R P STEPHENSON,et al.  A MODIFICATION OF RECEPTOR THEORY , 1997, British journal of pharmacology and chemotherapy.

[24]  T. Kenakin,et al.  The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy. , 1996, Journal of theoretical biology.

[25]  P. Morgan,et al.  The Cubic Ternary Complex ReceptorOccupancy Model I. Model Description , 1996 .

[26]  T. Kenakin,et al.  THE CUBIC TERNARY COMPLEX RECEPTOR-OCCUPANCY MODEL. II. UNDERSTANDING APPARENT AFFINITY , 1996 .

[27]  K. Racké,et al.  Muscarinic inhibition of endogenous noradrenaline release from rabbit isolated trachea: receptor subtype and receptor reserve , 1994, Naunyn-Schmiedeberg's Archives of Pharmacology.

[28]  R. Lefkowitz,et al.  Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. , 1993, Trends in pharmacological sciences.

[29]  R. Lefkowitz,et al.  A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. , 1993, The Journal of biological chemistry.

[30]  N. Shankley,et al.  Interpretation of agonist affinity estimations: the question of distributed receptor states , 1990, Proceedings of the Royal Society of London. B. Biological Sciences.

[31]  Palmer Taylor,et al.  Principles of Drug Action , 1990 .

[32]  G. Martin,et al.  Estimation of agonist affinity and efficacy by direct, operational model-fitting. , 1990, Journal of pharmacological methods.

[33]  J. Wyman,et al.  Binding and Linkage: Functional Chemistry of Biological Macromolecules , 1990 .

[34]  D. G. Watts,et al.  Nonlinear Regression Analysis and Its Applications , 1988 .

[35]  D. Mackay.  Concentration-response curves and receptor classification: null method or operational model? , 1988, Trends in pharmacological sciences.

[36]  J. W. Wells,et al.  Assessment of a ternary model for the binding of agonists to neurohumoral receptors. , 1986, Biochemistry.

[37]  J. Black,et al.  An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation , 1985, British journal of pharmacology.

[38]  J. Black,et al.  Operational models of pharmacological agonism , 1983, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[39]  R. Lefkowitz,et al.  A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. , 1980, The Journal of biological chemistry.

[40]  A. Levitzki,et al.  Ligand competition curves as a diagnostic tool for delineating the nature of site-site interactions: theory. , 1979, European journal of biochemistry.

[41]  I. M. Klotz,et al.  Protein affinities for small molecules: conceptions and misconceptions. , 1979, Archives of biochemistry and biophysics.

[42]  F. J. Richards.  A Flexible Growth Function for Empirical Use , 1959 .

[43]  Bernard Katz,et al.  Interaction at end-plate receptors between different choline derivatives , 1957, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[44]  R. Sips,et al.  On the Structure of a Catalyst Surface , 1948 .

[45]  T. Kenakin.  Kenakin replies [2] , 1998 .

[46]  J. Black,et al.  A personal view of pharmacology. , 1996, Annual review of pharmacology and toxicology.

[47]  D. Jenkinson.  Finding affinity constants for agonists by the irreversible antagonists method. , 1989, Trends in pharmacological sciences.

[48]  J. Edsall,et al.  Biothermodynamics: The Study of Biochemical Processes at Equilibrium , 1983 .

[49]  J. Dumont,et al.  Outlines of receptor theory , 1980 .

[50]  Benjamin Gompertz,et al.  XXIV. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. In a letter to Francis Baily, Esq. F. R. S. &c , 1825, Philosophical Transactions of the Royal Society of London.

[51]  Benjamin Gompertz,et al.  On the Nature of the Function Expressive of the Law of Human Mortality , 1815 .