Synthesis of copolymer-stabilized silver nanoparticles for coating materials

Silver ions being less toxic than silver nanoparticles, a more safe material can be obtained to be used as antimicrobial coating. This can be achieved by using thiol chemistry and covalently attach the silver nanoparticles in the coating. Our aim is to produce a coating having antimicrobial properties of silver ions but with the silver nanoparticles firmly attached in the coating. Here, we present a way to produce silver nanoparticles that can be used as a component in a coating or as such to produce an antimicrobial coating. The silver nanoparticles presented here are stabilized by a copolymer (poly(butyl acrylate–methyl methacrylate)) that is soft and has well-known good film-producing properties. The reversible addition-fragmentation chain transfer radical polymerization technique used to prepare the polymers provides conveniently a thiol group for effective binding of the silver nanoparticles to the polymers and thus to the coating.

[1]  Younan Xia,et al.  Synthesis of silver nanostructures with controlled shapes and properties. , 2007, Accounts of chemical research.

[2]  Feng Yan,et al.  A gold nanoparticles/sol-gel composite architecture for encapsulation of immunoconjugate for reagentless electrochemical immunoassay. , 2006, Biomaterials.

[3]  M. Hande,et al.  Cytotoxicity and genotoxicity of silver nanoparticles in human cells. , 2009, ACS nano.

[4]  Xuchuan Jiang,et al.  A self-seeding coreduction method for shape control of silver nanoplates , 2006 .

[5]  Jun-Yan Zhang,et al.  Silver nanoparticles capped by oleylamine: formation, growth, and self-organization. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[6]  Sunho Jeong,et al.  Synthesis of silver nanoparticles using the polyol process and the influence of precursor injection , 2006, Nanotechnology.

[7]  S. Stevens,et al.  Multiple parameters for the comprehensive evaluation of the susceptibility of Escherichia coli to the silver ion , 2004, Biometals.

[8]  Chitta Ranjan Patra,et al.  Gold Nanoparticles Inhibit the Proliferation of Multiple Myeloma Cells , 2007 .

[9]  Mathias Brust,et al.  Synthesis of thiol-derivatised gold nanoparticles in a two-phase liquid-liquid system , 1994 .

[10]  Aine M. Whelan,et al.  A rapid, straight-forward method for controlling the morphology of stable silver nanoparticles , 2007 .

[11]  J. Schlager,et al.  DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. , 2008, Toxicology and applied pharmacology.

[12]  Subra Suresh,et al.  Size‐Dependent Endocytosis of Nanoparticles , 2009, Advanced materials.

[13]  Priyabrata Mukherjee,et al.  Biological properties of "naked" metal nanoparticles. , 2008, Advanced drug delivery reviews.

[14]  H. Jiang,et al.  Preparation of poly(N-isopropylacrylamide)-monolayer protected gold clusters: synthesis methods, core size and thickness of monolayer , 2003 .

[15]  Arnab Roy,et al.  Characterization of enhanced antibacterial effects of novel silver nanoparticles , 2007, Nanotechnology.

[16]  R O Becker,et al.  Antibacterial Effects of Silver Electrodes with Weak Direct Current , 1974, Antimicrobial Agents and Chemotherapy.

[17]  Dae Hong Jeong,et al.  Antimicrobial effects of silver nanoparticles. , 2007, Nanomedicine : nanotechnology, biology, and medicine.

[18]  Michael J Yaszemski,et al.  Potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): enhancing apoptosis , 2007, Journal of nanobiotechnology.

[19]  R O Becker,et al.  Electrically Generated Silver Ions: Quantitative Effects on Bacterial and Mammalian Cells , 1976, Antimicrobial Agents and Chemotherapy.

[20]  M. Torkkeli,et al.  Grafting of montmorillonite nano-clay with butyl acrylate and methyl methacrylate by atom transfer radical polymerization: Blends with poly(BuA-co-MMA) , 2009 .

[21]  Anthony Atala,et al.  Gold Nanoparticles Inhibit VEGF165-Induced Proliferation of HUVEC Cells , 2004 .

[22]  Audrey Moores,et al.  The plasmon band in noble metal nanoparticles: an introduction to theory and applications , 2006 .

[23]  C. Feldmann,et al.  Polyol-Mediated Preparation of Nanoscale Oxide Particles. , 2001, Angewandte Chemie.

[24]  H. Rosenberg,et al.  Effect of silver ions on transport and retention of phosphate by Escherichia coli , 1982, Journal of bacteriology.

[25]  Ling Wang,et al.  Antiangiogenic Properties of Gold Nanoparticles , 2005, Clinical Cancer Research.

[26]  F. Cui,et al.  A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. , 2000, Journal of biomedical materials research.

[27]  M. Fiori,et al.  Synthesis, characterization and antibacterial activity studies of poly-{styrene-acrylic acid} with silver nanoparticles , 2009 .

[28]  H. Terryn,et al.  The formation and characterisation of ultra-thin films containing Ag nanoparticles , 2008 .

[29]  I. Sondi,et al.  Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. , 2004, Journal of colloid and interface science.

[30]  J. Turkevich,et al.  Coagulation of Colloidal Gold , 2002 .

[31]  Catherine J. Murphy,et al.  Evidence for Seed-Mediated Nucleation in the Chemical Reduction of Gold Salts to Gold Nanoparticles , 2001 .

[32]  R. Becker,et al.  Antifungal Properties of Electrically Generated Metallic Ions , 1976, Antimicrobial Agents and Chemotherapy.

[33]  B. Sumerlin,et al.  Facile preparation of transition metal nanoparticles stabilized by well-defined (co)polymers synthesized via aqueous reversible addition-fragmentation chain transfer polymerization. , 2002, Journal of the American Chemical Society.