A general description for Chinese medicine in treating premature ovarian failure

Premature ovarian failure (POF) is a kind of gynecological disease that causes amenorrhea, infertility, menopause and urogenital symptoms. Currently hormone replacement therapy (HRT) is the most popular choice for women with POF to get rid of menopausal syndrome. However, as the popularization of Chinese herbs made Chinese medicine (CM) shine new lights, physicians are able to treat POF with both meno-herbs and integrated therapy. HRT has its own indications and contraindications. For example, unexplained vaginal bleeding, acute liver damage, liver dysfunction, vascular embolization, and breast cancer are all contraindications of HRT, and CM is taken by more physicians as an adjuvant therapy. This review, including a range of common Chinese herbs and formulations according to the existing literature, provides a general description of CM treating POF from the aspects of mechanisms and clinical application. It also highlights acupuncture as a unique physiotherapy for POF. Although the validity of CM has been supported by the evidence of many preclinical trials, clinical trials and meta-analysis, the adverse events with CM therapy still exist and no guarantee has been made for its safety. This review concludes the updated information for CM treating POF contributing to further studies.

[1]  N. Rege,et al.  ICH Harmonised Tripartite Guideline: guideline for good clinical practice. , 2001, Journal of postgraduate medicine.

[2]  Fan Qu,et al.  Treating gynaecological disorders with traditional Chinese medicine: a review. , 2010, African journal of traditional, complementary, and alternative medicines : AJTCAM.

[3]  K. Kerlikowske,et al.  Hormone replacement therapy and endometrial cancer risk: a meta-analysis. , 1995, Obstetrics and gynecology.

[4]  Myeong Soo Lee,et al.  Effects of acupuncture on hot flashes in perimenopausal and postmenopausal women-a multicenter randomized clinical trial , 2010, Menopause.

[5]  Xue-feng Xiao,et al.  Phytochemical and pharmacological studies on Radix Angelica sinensis. , 2013, Chinese journal of natural medicines.

[6]  Xue-feng Xiao,et al.  Phytochemical and pharmacological studies on Radix Angelica sinensis: Phytochemical and pharmacological studies on Radix Angelica sinensis , 2014 .

[7]  V. Beral,et al.  Hormone replacement therapy and false positive recall in the Million Women Study: patterns of use, hormonal constituents and consistency of effect , 2005, Breast Cancer Research.

[8]  Xiaotong Wang,et al.  Acupuncture and Auricular Acupressure in Relieving Menopausal Hot Flashes of Bilaterally Ovariectomized Chinese Women: A Randomized Controlled Trial , 2010, Evidence-based complementary and alternative medicine : eCAM.

[9]  R. Hagerman,et al.  Fragile X spectrum disorders. , 2014, Intractable & rare diseases research.

[10]  S. Wachtel-Galor,et al.  Herbal Medicine: Biomolecular and Clinical Aspects , 2011 .

[11]  Xiumei Gao,et al.  Cuscuta chinensis Lam.: A systematic review on ethnopharmacology, phytochemistry and pharmacology of an important traditional herbal medicine. , 2014, Journal of ethnopharmacology.

[12]  V. Beral.  Ovarian cancer and hormone replacement therapy in the Million Women Study , 2007, The Lancet.

[13]  P. Song,et al.  A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo. , 2014, Drug discoveries & therapeutics.

[14]  Z. Zhang,et al.  A randomized, double-blind, controlled trial of a Chinese herbal formula (Er-Xian decoction) for menopausal symptoms in Hong Kong perimenopausal women. , 2013, Menopause.

[15]  H. Kuang,et al.  American Ginseng Regulates Gene Expression to Protect against Premature Ovarian Failure in Rats , 2015, BioMed research international.

[16]  G. Conway,et al.  Premature ovarian failure. , 2005, Human reproduction update.

[17]  Huan Yang,et al.  pS2 expression induced by American ginseng in MCF-7 breast cancer cells , 1996, Annals of Surgical Oncology.

[18]  M. Pike,et al.  Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk , 2016, Obstetrics and gynecology.

[19]  Penghui Feng,et al.  Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling , 2018, Stem Cell Reviews and Reports.

[20]  Myeong Soo Lee,et al.  Acupuncture for Hot Flushes in Perimenopausal and Postmenopausal Women: A Randomised, Sham-Controlled Trial , 2011, Acupuncture in medicine : journal of the British Medical Acupuncture Society.

[21]  H H Fong,et al.  Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. , 2001, Journal of agricultural and food chemistry.

[22]  S. Koch.  Pharmacology And Applications Of Chinese Materia Medica , 2016 .

[23]  J. Annegers,et al.  Incidence of Premature Ovarian Failure , 1986, Obstetrics and gynecology.

[24]  Zhengtao Wang,et al.  Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism. , 2014, Bioscience trends.

[25]  S. Cha,et al.  Acupuncture for hot flashes: a randomized, sham-controlled clinical study , 2007, Menopause.

[26]  L. Nelson.  Clinical practice. Primary ovarian insufficiency. , 2009, The New England journal of medicine.

[27]  Y. Wu,et al.  Chinese Herbal Medicine for premature ovarian failure: A systematic review and meta-analysis , 2014 .

[28]  Zheng-hua Yan,et al.  [Effect of shu di-huang on the transmitter and receptor of amino acid in brain and learning and memory of dementia model]. , 2003, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[29]  Z J Zhang,et al.  A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome. , 2009, Journal of ethnopharmacology.

[30]  M. Stefanick.  Estrogens and progestins: background and history, trends in use, and guidelines and regimens approved by the US Food and Drug Administration. , 2005, The American journal of medicine.

[31]  I. Schiff,et al.  Research opportunities for reducing the burden of menopause-related symptoms. , 2005, The American journal of medicine.

[32]  Kun Ma,et al.  [A multi-center, randomized, double-blind clinical study on Bushen Huoxue in treatment of ovulatory dysfunction caused infertility]. , 2015, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[33]  K. Juárez-Rendón,et al.  “Evaluation of four genes associated with primary ovarian insufficiency in a cohort of Mexican women” , 2018, Journal of Assisted Reproduction and Genetics.

[34]  Yuan Yu,et al.  Antiosteoporotic activity of Er-Xian Decoction, a traditional Chinese herbal formula, in ovariectomized rats. , 2006, Journal of ethnopharmacology.

[35]  K. Ried,et al.  Efficacy of Traditional Chinese Herbal Medicine in the management of female infertility: a systematic review. , 2011, Complementary therapies in medicine.

[36]  W. Setzer,et al.  A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements , 2015, In Silico Pharmacology.

[37]  Xuemin Qiu,et al.  Bu-Shen-Ning-Xin decoction suppresses osteoclastogenesis via increasing dehydroepiandrosterone to prevent postmenopausal osteoporosis. , 2015, Bioscience trends.

[38]  Jianjun Gao,et al.  Research progress on flavonoids isolated from traditional Chinese medicine in treatment of Alzheimer's disease. , 2013, Intractable & rare diseases research.

[39]  He-feng Huang,et al.  An update on primary ovarian insufficiency , 2012, Science China Life Sciences.

[40]  V. Beral,et al.  Endometrial cancer and hormone-replacement therapy in the Million Women Study. , 2005, Lancet.

[41]  Yoshinori Inagaki,et al.  Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer. , 2010, Bioscience trends.

[42]  Bi-Hong Xu,et al.  [Treatment of premature ovarian failure patients by bushen tiaojing recipe combined hormone replacement therapy: a clinical observation]. , 2013, Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.

[43]  J. Pitkin.  Red Clover Isoflavones in Practice: A Clinician's View , 2004, The journal of the British Menopause Society.

[44]  Lin Zhao,et al.  The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer. , 2015, Bioscience trends.

[45]  P. Komesaroff,et al.  A Chinese Herbal Preparation Containing Radix Salviae Miltiorrhizae, Radix Notoginseng and Borneolum Syntheticum Reduces Circulating Adhesion Molecules , 2011, Evidence-based complementary and alternative medicine : eCAM.

[46]  Xiangshan Zhou,et al.  Chemical constituents and bioactivities of Panax ginseng (C. A. Mey.). , 2015, Drug discoveries & therapeutics.

[47]  J. Duan,et al.  Herb pairs containing Angelicae Sinensis Radix (Danggui): A review of bio-active constituents and compatibility effects. , 2016, Journal of ethnopharmacology.

[48]  Jinguo Yang,et al.  Protective effects on vascular endothelial cell in N'-nitro-L-arginine (L-NNA)-induced hypertensive rats from the combination of effective components of Uncaria rhynchophylla and Semen Raphani. , 2015, Bioscience trends.

[49]  She Yun-chu.  Effects of Flavonoids of Semen Cuscutae on Reproductive Function of Animals , 2000 .

[50]  N. Santoro,et al.  Premature ovarian failure (POF): discordance between somatic and reproductive aging , 2002, Ageing Research Reviews.

[51]  Hong Zhao,et al.  Bushen Ningxin Decoction pharmacological serum promotes the proliferation and suppresses the apoptosis of murine osteoblasts through MAPK pathway. , 2009, Journal of ethnopharmacology.

[52]  F. Tassone,et al.  Distribution of AGG interruption patterns within nine world populations. , 2014, Intractable & rare diseases research.