Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease.

To investigate the effect of single nucleotide polymorphisms (SNPs) of the upstream stimulatory factor (USF) 1 and 2 genes on the onset of Alzheimer's disease (AD), a case-control study was performed. The SNPs were genotyped by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 236 AD patients and 120 age-matched controls of Japanese descent. We observed no significant association between the three SNPs of the USF 1 gene and AD in our Japanese participants. In addition, the SNPs studied did not affect plasma cholesterol levels in our AD cases. For the USF 2 gene, the two SNPs did not show significant association with onset of AD. Our study suggests that the three SNPs of the USF 1 gene and two SNPs of the USF 2 gene presented here are not associated with onset of AD.

[1]  H. Coon,et al.  Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides , 2005, Human Genetics.

[2]  C. Shoulders,et al.  USF1 implicated in the aetiology of familial combined hyperlipidaemia and the metabolic syndrome. , 2004, Trends in molecular medicine.

[3]  D. Tregouet,et al.  Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II. , 2004, Human molecular genetics.

[4]  S. Russek,et al.  cAMP Response Element-Binding Protein, Activating Transcription Factor-4, and Upstream Stimulatory Factor Differentially Control Hippocampal GABABR1a and GABABR1b Subunit Gene Expression through Alternative Promoters , 2004, The Journal of Neuroscience.

[5]  L. Peltonen,et al.  Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1) , 2004, Nature Genetics.

[6]  Sudha Seshadri,et al.  Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study. , 2003, Archives of internal medicine.

[7]  Wen G. Chen,et al.  Upstream Stimulatory Factors Are Mediators of Ca2+-Responsive Transcription in Neurons , 2003, The Journal of Neuroscience.

[8]  K. Yanagisawa.  Cholesterol and pathological processes in Alzheimer's disease , 2002, Journal of neuroscience research.

[9]  M. Tsuda,et al.  Involvement of an Upstream Stimulatory Factor as Well as cAMP-responsive Element-binding Protein in the Activation of Brain-derived Neurotrophic Factor Gene Promoter I* , 2002, The Journal of Biological Chemistry.

[10]  C. Schweiger.  [Statins and the risk of dementia]. , 2001, Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology.

[11]  H. Soininen,et al.  Genome-wide linkage disequilibrium mapping of late onset Alzheimer's disease in Finland , 2000, Neurobiology of Aging.

[12]  R. Tanzi,et al.  The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. , 1995, Human molecular genetics.

[13]  D. Goldgaber,et al.  USF binds to the APBα sequence in the promoter of the amyloid β-protein precursor gene , 1995 .

[14]  D. Goldgaber,et al.  USF binds to the APB alpha sequence in the promoter of the amyloid beta-protein precursor gene. , 1995, Nucleic acids research.

[15]  M A Pericak-Vance,et al.  Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. , 1993, Neurology.