A novel photoelectrochemical aptasensor based on the modulation of a dye sensitized TiO2 photoelectrode

An N719 dye labeled short DNA chain is introduced onto the surface of a TiO2 photoelectrode by hybridizing with a pre-immobilized thrombin aptamer to enhance the photocurrent response. After incubating with thrombin, both the dye labeled chain releasing from the photoelectrode and the bound thrombin blocking the electron transfer resulted in a decreased photocurrent.

[1]  Forrest S. Gittleson,et al.  Enhanced photoelectrochemical and sensing performance of novel TiO2 arrays to H2O2 detection , 2015 .

[2]  Songqin Liu,et al.  Construction of photoelectrochemical thrombin aptasensor via assembling multilayer of graphene-CdS nanocomposites. , 2015, Biosensors & bioelectronics.

[3]  Bin Du,et al.  Label-free photoelectrochemical immunosensor for sensitive detection of Ochratoxin A. , 2015, Biosensors & bioelectronics.

[4]  Qingyun Cai,et al.  Highly sensitive and selective photoelectrochemical biosensor platform for polybrominated diphenyl ether detection using the quantum dots sensitized three-dimensional, macroporous ZnO nanosheet photoelectrode. , 2014, Biosensors & bioelectronics.

[5]  Zhihui Dai,et al.  A carbon nanotube/quantum dot based photoelectrochemical biosensing platform for the direct detection of microRNAs. , 2014, Chemical communications.

[6]  Hongyuan Chen,et al.  Folding-based photoelectrochemical biosensor: binding-induced conformation change of a quantum dot-tagged DNA probe for mercury(II) detection. , 2014, Chemical communications.

[7]  Shuyan Niu,et al.  Ultrasensitive photoelectrochemical immunoassay of antibody against tumor-associated carbohydrate antigen amplified by functionalized graphene derivates and enzymatic biocatalytic precipitation. , 2014, Biosensors & bioelectronics.

[8]  Wei-Wei Zhao,et al.  Photoelectrochemical DNA biosensors. , 2014, Chemical reviews.

[9]  F. Huang,et al.  ZnO nanoflower-based photoelectrochemical DNAzyme sensor for the detection of Pb2+. , 2014, Biosensors & bioelectronics.

[10]  Gengfeng Zheng,et al.  Surface plasmon resonance enhanced real-time photoelectrochemical protein sensing by gold nanoparticle-decorated TiO₂ nanowires. , 2014, Analytical chemistry.

[11]  Guohua Zhao,et al.  A femtomolar level and highly selective 17β-estradiol photoelectrochemical aptasensor applied in environmental water samples analysis. , 2014, Environmental science & technology.

[12]  Zhihui Dai,et al.  Quantum dots sensitized titanium dioxide decorated reduced graphene oxide for visible light excited photoelectrochemical biosensing at a low potential. , 2014, Biosensors & bioelectronics.

[13]  Bing Sun,et al.  Signal-on photoelectrochemical biosensor for microRNA detection based on Bi2S3 nanorods and enzymatic amplification. , 2014, Biosensors & bioelectronics.

[14]  Wenjing Wang,et al.  Quantum dot-functionalized porous ZnO nanosheets as a visible light induced photoelectrochemical platform for DNA detection. , 2014, Nanoscale.

[15]  Zhihui Dai,et al.  In situ generated AgBr-enhanced ZnO nanorod-based photoelectrochemical aptasensing via layer-by-layer assembly. , 2014, Chemical communications.

[16]  Bing Sun,et al.  Ultrasensitive photoelectrochemical immunoassay of indole-3-acetic acid based on the MPA modified CdS/RGO nanocomposites decorated ITO electrode. , 2014, Biosensors & bioelectronics.

[17]  Yan Zhang,et al.  Application of ZnO/graphene and S6 aptamers for sensitive photoelectrochemical detection of SK-BR-3 breast cancer cells based on a disposable indium tin oxide device. , 2014, Biosensors & bioelectronics.

[18]  Jing Li,et al.  In situ-generated nano-gold plasmon-enhanced photoelectrochemical aptasensing based on carboxylated perylene-functionalized graphene. , 2014, Analytical chemistry.

[19]  Wei-Wei Zhao,et al.  Acetylcholine esterase antibodies on BiOI nanoflakes/TiO2 nanoparticles electrode: a case of application for general photoelectrochemical enzymatic analysis. , 2013, Analytical chemistry.

[20]  Ming Xu,et al.  Photoelectrochemical detection of glutathione by IrO2-hemin-TiO2 nanowire arrays. , 2013, Nano letters.

[21]  Wei-Wei Zhao,et al.  Ultrasensitive photoelectrochemical sensing of Pb2+ based on allosteric transition of G-Quadruplex DNAzyme , 2013 .

[22]  Linlin Tang,et al.  Visible-light-activated photoelectrochemical biosensor for the study of acetylcholinesterase inhibition induced by endogenous neurotoxins. , 2013, Biosensors & bioelectronics.

[23]  Michael Holzinger,et al.  Electrogenerated trisbipyridyl Ru(II)-/nitrilotriacetic-polypyrene copolymer for the easy fabrication of label-free photoelectrochemical immunosensor and aptasensor: application to the determination of thrombin and anti-cholera toxin antibody. , 2013, Biosensors & bioelectronics.

[24]  Qin Xu,et al.  A derivative photoelectrochemical sensing platform for 4-nitrophenolate contained organophosphates pesticide based on carboxylated perylene sensitized nano-TiO2. , 2013, Analytica chimica acta.

[25]  Xiaoru Zhang,et al.  Photoelectrochemically active species and photoelectrochemical biosensors , 2013 .

[26]  Xiaoru Zhang,et al.  A new photoelectrochemical biosensors based on DNA conformational changes and isothermal circular strand-displacement polymerization reaction. , 2013, Biosensors & bioelectronics.

[27]  Jinghua Yu,et al.  Visible light photoelectrochemical sensor based on Au nanoparticles and molecularly imprinted poly(o-phenylenediamine)-modified TiO2 nanotubes for specific and sensitive detection chlorpyrifos. , 2013, The Analyst.

[28]  Xiaoru Zhang,et al.  A new signal-on photoelectrochemical biosensor based on a graphene/quantum-dot nanocomposite amplified by the dual-quenched effect of bipyridinium relay and AuNPs. , 2012, Chemistry.

[29]  Itamar Willner,et al.  Photoelectrochemical Biosensors Without External Irradiation: Probing Enzyme Activities and DNA Sensing Using Hemin/G-Quadruplex-Stimulated Chemiluminescence Resonance Energy Transfer (CRET) Generation of Photocurrents , 2012 .

[30]  Qin Xu,et al.  Poly(3-hexylthiophene)/TiO2 nanoparticle-functionalized electrodes for visible light and low potential photoelectrochemical sensing of organophosphorus pesticide chlopyrifos. , 2011, Analytical chemistry.

[31]  Dai-Wen Pang,et al.  Aptamer biosensor based on fluorescence resonance energy transfer from upconverting phosphors to carbon nanoparticles for thrombin detection in human plasma. , 2011, Analytical chemistry.

[32]  Xiaoru Zhang,et al.  A new photoelectrochemical aptasensor for the detection of thrombin based on functionalized graphene and CdSe nanoparticles multilayers. , 2011, Chemical communications.

[33]  Meicheng Yang,et al.  A photoelectrochemical immunosensor based on Au-doped TiO2 nanotube arrays for the detection of α-synuclein. , 2010, Chemistry.

[34]  Huangxian Ju,et al.  Low-potential photoelectrochemical biosensing using porphyrin-functionalized TiO₂ nanoparticles. , 2010, Analytical chemistry.

[35]  Samir Elouatik,et al.  Further understanding of the adsorption mechanism of N719 sensitizer on anatase TiO2 films for DSSC applications using vibrational spectroscopy and confocal Raman imaging. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[36]  Itamar Willner,et al.  Electrochemical, photoelectrochemical, and surface plasmon resonance detection of cocaine using supramolecular aptamer complexes and metallic or semiconductor nanoparticles. , 2009, Analytical chemistry.

[37]  Guang-Li Wang,et al.  Dopamine sensitized nanoporous TiO2 film on electrodes: photoelectrochemical sensing of NADH under visible irradiation. , 2009, Biosensors & bioelectronics.

[38]  Minmin Liang,et al.  Photoelectrochemical DNA sensor for the rapid detection of DNA damage induced by styrene oxide and the Fenton reaction. , 2007, Environmental science & technology.

[39]  Kevin W Plaxco,et al.  A reagentless signal-on architecture for electronic, aptamer-based sensors via target-induced strand displacement. , 2005, Journal of the American Chemical Society.

[40]  Yoko Yamada,et al.  Photoelectrochemical deoxyribonucleic acid sensing on a nanostructured TiO2 electrode , 2005 .

[41]  A. Heeger,et al.  Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor. , 2005, Angewandte Chemie.

[42]  Itamar Willner,et al.  Photoelectrochemistry with Controlled DNA-Cross-Linked CdS Nanoparticle Arrays This research is supported by The U.S.-Israel Binational Science Foundation. The Max Planck Research Award for International Cooperation (I.W.) is gratefully acknowledged. , 2001, Angewandte Chemie.

[43]  P. Liska,et al.  Acid-Base Equilibria of (2,2'-Bipyridyl-4,4'-dicarboxylic acid)ruthenium(II) Complexes and the Effect of Protonation on Charge-Transfer Sensitization of Nanocrystalline Titania. , 1999, Inorganic chemistry.

[44]  Polycarpos Falaras,et al.  Synergetic effect of carboxylic acid functional groups and fractal surface characteristics for efficient dye sensitization of titanium oxide , 1998 .

[45]  M. Grätzel.  Photoelectrochemical cells : Materials for clean energy , 2001 .