p53 tumour suppressor

Other speculated functions include1⁄4 does it really need more? Well, it seems to function in multicellular development and differentiation, too, and there’s some evidence that it’s an exonuclease. If you’re beginning to think that researchers from all areas of biology are obsessed with p53, witness the number of grant applications claiming that studies of p53 will provide a cure for cancer, explaining the cell cycle, DNA repair and morphogenesis along the way.

[1]  M L Agarwal,et al.  The p53 Network* , 1998, The Journal of Biological Chemistry.

[2]  C. Prives,et al.  p53: puzzle and paradigm. , 1996, Genes & development.

[3]  M. Oren,et al.  p53; from inductive signal to cellular effect. , 1997, Current opinion in genetics & development.

[4]  D. Lane,et al.  p53--integrating the complexity. , 1996, The Journal of pathology.

[5]  A. Levine p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.

[6]  D. Lane,et al.  Tumour suppressors: A developing role for p53? , 1997, Current Biology.