Nutrient signaling to mTOR and cell growth.
暂无分享,去创建一个
[1] Sang Gyun Kim,et al. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. , 2013, Molecular cell.
[2] R. Deberardinis,et al. The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. , 2012, Molecular cell.
[3] K. E. van der Vos,et al. Glutamine metabolism links growth factor signaling to the regulation of autophagy , 2012, Autophagy.
[4] D. Sabatini,et al. Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1 , 2012, Cell.
[5] Roberto Zoncu,et al. Amino acids and mTORC1: from lysosomes to disease. , 2012, Trends in molecular medicine.
[6] P. Finan,et al. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. , 2012, Molecular cell.
[7] E. Gottlieb,et al. Glutaminolysis activates Rag-mTORC1 signaling. , 2012, Molecular cell.
[8] M. G. Koerkamp,et al. Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy , 2012, Nature Cell Biology.
[9] Timothy J Griffin,et al. SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. , 2012, Molecular cell.
[10] D. Goberdhan,et al. Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes , 2012, PloS one.
[11] C. De Virgilio,et al. Leucyl-tRNA synthetase controls TORC1 via the EGO complex. , 2012, Molecular cell.
[12] Sunghoon Kim,et al. Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway , 2012, Cell.
[13] D. Sabatini,et al. A unifying model for mTORC1-mediated regulation of mRNA translation , 2012, Nature.
[14] D. Sabatini,et al. mTOR Signaling in Growth Control and Disease , 2012, Cell.
[15] D. Hardie,et al. AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.
[16] Nicholas T. Ingolia,et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis , 2012, Nature.
[17] P. Soares,et al. The mTOR Signalling Pathway in Human Cancer , 2012, International journal of molecular sciences.
[18] G. Bellenchi,et al. Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin , 2012, Proceedings of the National Academy of Sciences.
[19] Roberto Zoncu,et al. mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase , 2011, Science.
[20] J. Backer,et al. Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway , 2011, The Journal of cell biology.
[21] M. Pagano,et al. mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR. , 2011, Molecular cell.
[22] S. Gygi,et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. , 2011, Molecular cell.
[23] Yi Sun,et al. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy. , 2011, Molecular cell.
[24] Aleksey A. Porollo,et al. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. , 2011, Molecular cell.
[25] R. Shaw,et al. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism , 2011, Nature Cell Biology.
[26] K. Guan,et al. Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. , 2011, Genes & development.
[27] E. Jacinto,et al. mTOR complex 2 signaling and functions , 2011, Cell cycle.
[28] K. Guan,et al. Amino acid signaling in TOR activation. , 2011, Annual review of biochemistry.
[29] Michael A. Koldobskiy,et al. Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. , 2011, Cell metabolism.
[30] B. Viollet,et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.
[31] D. Sabatini,et al. mTOR: from growth signal integration to cancer, diabetes and ageing , 2010, Nature Reviews Molecular Cell Biology.
[32] Z. Hořejší,et al. CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. , 2010, Molecular cell.
[33] Eric D. Spear,et al. Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals. , 2010, Journal of molecular biology.
[34] D. Goberdhan,et al. Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation , 2010, Oncogene.
[35] D. Hailey,et al. Autophagy termination and lysosome reformation regulated by mTOR , 2010, Nature.
[36] T. P. Neufeld,et al. Regulation of mTORC1 by the Rab and Arf GTPases* , 2010, The Journal of Biological Chemistry.
[37] Tohru Natsume,et al. Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly* , 2010, The Journal of Biological Chemistry.
[38] D. Sabatini,et al. Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids , 2010, Cell.
[39] D. Burgess,et al. PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR. , 2010, Molecular cell.
[40] Nicolas Panchaud,et al. The Vam6 GEF controls TORC1 by activating the EGO complex. , 2009, Molecular cell.
[41] She Chen,et al. ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy* , 2009, Journal of Biological Chemistry.
[42] J. Blenis,et al. Molecular mechanisms of mTOR-mediated translational control , 2009, Nature Reviews Molecular Cell Biology.
[43] C. Jung,et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. , 2009, Molecular biology of the cell.
[44] J. Avruch,et al. Amino acid regulation of TOR complex 1. , 2009, American journal of physiology. Endocrinology and metabolism.
[45] M. Okada,et al. The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes , 2009, The EMBO journal.
[46] Jeffrey P. MacKeigan,et al. Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy , 2009, Cell.
[47] M. Murakami,et al. RalA Functions as an Indispensable Signal Mediator for the Nutrient-sensing System* , 2008, Journal of Biological Chemistry.
[48] Jie Chen,et al. mTOR signaling: PLD takes center stage , 2008, Cell cycle.
[49] T. P. Neufeld,et al. Regulation of TORC1 by Rag GTPases in nutrient response , 2008, Nature Cell Biology.
[50] David M. Sabatini,et al. The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 , 2008, Science.
[51] F. Natt,et al. Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. , 2008, Cell metabolism.
[52] B. Turk,et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.
[53] T. Lange,et al. Tel2 Regulates the Stability of PI3K-Related Protein Kinases , 2007, Cell.
[54] V. Mieulet,et al. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. , 2007, The Biochemical journal.
[55] K. Isobe,et al. GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress. , 2007, International journal of molecular medicine.
[56] Ming You,et al. TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth , 2006, Cell.
[57] V. Stambolic,et al. Localization of Rheb to the endomembrane is critical for its signaling function. , 2006, Biochemical and biophysical research communications.
[58] M. Brandsch,et al. Substrate specificity of the amino acid transporter PAT1 , 2006, Amino Acids.
[59] D. Sabatini,et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. , 2006, Molecular cell.
[60] M. Neeman,et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. , 2006, Cancer cell.
[61] K. Inoki,et al. TSC1 Stabilizes TSC2 by Inhibiting the Interaction between TSC2 and the HERC1 Ubiquitin Ligase* , 2006, Journal of Biological Chemistry.
[62] Hong Chen,et al. Nutritional control of gene expression: how mammalian cells respond to amino acid limitation. , 2005, Annual review of nutrition.
[63] E. Cameroni,et al. The TOR and EGO protein complexes orchestrate microautophagy in yeast. , 2005, Molecular cell.
[64] J. Avruch,et al. Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency* , 2005, Journal of Biological Chemistry.
[65] D. Meredith,et al. PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids , 2005, Development.
[66] Joseph Avruch,et al. Rheb Binds and Regulates the mTOR Kinase , 2005, Current Biology.
[67] E. Hafen,et al. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. , 2004, Genes & development.
[68] E. Hafen,et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. , 2004, Genes & development.
[69] R. Loewith,et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive , 2004, Nature Cell Biology.
[70] T. Anthony,et al. Preservation of Liver Protein Synthesis during Dietary Leucine Deprivation Occurs at the Expense of Skeletal Muscle Mass in Mice Deleted for eIF2 Kinase GCN2* , 2004, Journal of Biological Chemistry.
[71] D. Guertin,et al. Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton , 2004, Current Biology.
[72] Sebastian Maurer-Stroh,et al. Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[73] M. Cygler,et al. The Structure of the MAPK Scaffold, MP1, Bound to Its Partner, p14 , 2004, Journal of Biological Chemistry.
[74] K. Inoki,et al. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. , 2003, Genes & development.
[75] B. Edgar,et al. Rheb promotes cell growth as a component of the insulin/TOR signalling network , 2003, Nature Cell Biology.
[76] E. Hafen,et al. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila , 2003, Nature Cell Biology.
[77] B. Edgar,et al. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins , 2003, Nature Cell Biology.
[78] E. Hafen,et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. , 2003, Molecular cell.
[79] Paul Tempst,et al. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. , 2003, Molecular cell.
[80] S. Kimball,et al. The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice , 2002, Molecular and Cellular Biology.
[81] David J. Kwiatkowski,et al. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[82] J. Crespo,et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. , 2002, Molecular cell.
[83] D. Sabatini,et al. mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery , 2002, Cell.
[84] B. Giros,et al. Identification and characterization of a lysosomal transporter for small neutral amino acids , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[85] D. Ron,et al. Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α , 2001, The Journal of cell biology.
[86] G. Benvenuto,et al. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination , 2000, Oncogene.
[87] C. Proud,et al. Amino acid availability regulates p70 S6 kinase and multiple translation factors. , 1998, The Biochemical journal.
[88] J. Avruch,et al. Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism* , 1998, The Journal of Biological Chemistry.
[89] R. Abraham,et al. Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells (*) , 1995, The Journal of Biological Chemistry.
[90] Paul Tempst,et al. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs , 1994, Cell.
[91] Stuart L. Schreiber,et al. A mammalian protein targeted by G1-arresting rapamycin–receptor complex , 1994, Nature.
[92] J. Kunz,et al. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression , 1993, Cell.
[93] J. Heitman,et al. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast , 1991, Science.
[94] 細川 奈生. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy , 2010 .
[95] A. Wittinghofer,et al. GEFs and GAPs: Critical Elements in the Control of Small G Proteins , 2007, Cell.