The 62 MeV proton beam for the treatment of ocular melanoma at Clatterbridge.

A second treatment room and beam line has been constructed at the Cyclotron Unit at Clatterbridge for the purpose of using 62 MeV protons for the treatment of ocular melanoma. A uniform beam is produced by a double foil scattering system. The initial Bragg peak is spread across the target volume by the use of beam modulators. These are rotating four-vaned stepped absorbers made from Perspex. Two beam lines can be configured with different positions of modulators and range limiters. The first has a maximum penetration of 31.9 +/- 0.2 mm in water and the second a penetration of 31.2 +/- 0.2 mm. The second configuration has the advantage of less variation in beam penumbra, with a typical value of 1.7 +/- 0.1 mm for the 90% to 10% decrement lines. The patients are treated with individually shaped collimators. Beam output varies by less than 2% over the range of collimator areas used. The resulting whole-body dose equivalent to patient has also been assessed. In the first three years of operation over 250 patients have been treated.

[1]  M Goitein,et al.  Proton Beam Irradiation: An Alternative to Enucleation for Intraocular Melanomas , 1980 .

[2]  D. Bonnett,et al.  Code of practice for clinical proton dosimetry. , 1991, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[3]  M Goitein,et al.  Planning proton therapy of the eye. , 1983, Medical physics.

[4]  A. Koehler,et al.  Protons in radiation therapy. Comparative dose distributions for protons, photons, and electrons. , 1972, Radiology.

[5]  D. Bonnett,et al.  Radiation protection metrology at a high-energy neutron therapy facility , 1991 .

[6]  Robert J. Schneider,et al.  Range modulators for protons and heavy ions , 1975 .

[7]  M Goitein,et al.  Energy of proton accelerator necessary for treatment of choroidal melanomas. , 1983, International journal of radiation oncology, biology, physics.

[8]  A M Koehler,et al.  Flattening of proton dose distributions for large-field radiotherapy. , 1977, Medical physics.

[9]  I. Constable,et al.  Proton irradiation of choroidal melanomas. Preliminary results. , 1978, Archives of ophthalmology.

[10]  L. Verhey,et al.  Relative biological effectiveness of modulated proton beams in various murine tissues. , 1984, International journal of radiation oncology, biology, physics.