Interplay of direct stereocontrol and dynamic kinetic resolution in a bifunctional amine thiourea catalyzed highly enantioselective cascade Michael-Michael reaction.

[1]  M. Terada,et al.  Chiral brønsted acid-catalyzed tandem aza-ene type reaction/cyclization cascade for a one-pot entry to enantioenriched piperidines. , 2007, Journal of the American Chemical Society.

[2]  M. Rueping,et al.  A highly enantioselective Brønsted acid catalyzed cascade reaction: organocatalytic transfer hydrogenation of quinolines and their application in the synthesis of alkaloids. , 2006, Angewandte Chemie.

[3]  Magnus Rueping,et al.  Eine hoch enantioselektive Brønsted‐Säure‐katalysierte Kaskadenreaktion: organokatalytische Transferhydrierung von Chinolinen und deren Anwendung in der Synthese von Alkaloiden , 2006 .

[4]  Abigail G Doyle,et al.  Small-molecule H-bond donors in asymmetric catalysis. , 2007, Chemical reviews.

[5]  G. Cook.  Transition Metal-Mediated Kinetic Resolution , 2000 .

[6]  D. MacMillan,et al.  The advent and development of organocatalysis , 2008, Nature.

[7]  Jian Wang,et al.  Enantioselective organocatalytic double Michael addition reactions. , 2007, Organic letters.

[8]  A. Dondoni,et al.  Asymmetrische Organokatalyse: Eintritt in die Reifezeit† , 2008 .

[9]  C. Nájera,et al.  Organocatalytic asymmetric conjugate additions , 2007 .

[10]  E. De Clercq,et al.  Thiosugars. Part 9: synthesis and biological evaluation of some 4'-thio-L-arabino nucleoside analogues. , 2001, Bioorganic & medicinal chemistry letters.

[11]  T. Akiyama,et al.  Stronger Brønsted acids. , 2007, Chemical reviews.

[12]  L. Tang,et al.  Highly enantioselective conjugate addition of malonate and beta-ketoester to nitroalkenes: asymmetric C-C bond formation with new bifunctional organic catalysts based on cinchona alkaloids. , 2004, Journal of the American Chemical Society.

[13]  Derek S. Tan,et al.  Diversity-oriented synthesis: exploring the intersections between chemistry and biology , 2005, Nature chemical biology.

[14]  Martin D. Burke,et al.  Eine Strategie für die Diversitäts‐orientierte Synthese , 2004 .

[15]  Jian Wang,et al.  A highly stereoselective hydrogen-bond-mediated Michael-Michael cascade process through dynamic kinetic resolution. , 2008, Angewandte Chemie.

[16]  D. Enders,et al.  Asymmetrische organokatalytische Dominoreaktionen , 2007 .

[17]  P. Beswick,et al.  Synthesis of an isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B receptor antagonist tetronothiodin , 2003 .

[18]  T. Akiyama,et al.  Recent Progress in Chiral Brønsted Acid Catalysis , 2006 .

[19]  P. Pihko.  Hydrogen bonding in organic synthesis , 2009 .

[20]  Jean-Pierre Vigneron,et al.  Nouvelle methode pour porter au maximum la purete optique d'un produit partiellement dedouble sans l'aide d'aucune substance chirale , 1973 .

[21]  D. Enders,et al.  Organocatalytic cascade reactions as a new tool in total synthesis. , 2010, Nature chemistry.

[22]  K. Nambiar,et al.  Asymmetric Total Synthesis of Erythromycin. 1. Synthesis of an Erythronolide A Seco Acid Derivative via Asymmetric Induction , 1981 .

[23]  P. D. Clercq.  Biotin: A Timeless Challenge for Total Synthesis , 1997 .

[24]  Jian Wang,et al.  Chiral Amine Thiourea‐Promoted Enantioselective Domino Michael‐Aldol Reactions between 2‐Mercaptobenzaldehydes and Maleimides , 2007 .

[25]  Baomin Wang,et al.  Control of diastereoselectivity in tandem asymmetric reactions generating nonadjacent stereocenters with bifunctional catalysis by cinchona alkaloids. , 2007, Journal of the American Chemical Society.

[26]  L. Gong,et al.  Organocatalytic asymmetric formal [3+2] cycloaddition reaction of isocyanoesters to nitroolefins leading to highly optically active dihydropyrroles. , 2008, Angewandte Chemie.

[27]  G. Morgant,et al.  Asymmetric Michael reaction involving chiral imines/secondary enamines: stereocontrolled synthesis of 2,2-disubstituted tetrahydrothiophen-3-ones. , 2004, Organic letters.

[28]  Yongxin Li,et al.  Organocatalytic asymmetric tandem Michael-Henry reactions: a highly stereoselective synthesis of multifunctionalized cyclohexanes with two quaternary stereocenters. , 2008, Organic letters.

[29]  J. V. van Maarseveen,et al.  Asymmetric organocatalytic Henry reaction. , 2006, Angewandte Chemie.

[30]  M. Yus,et al.  Tetrahedron: Asymmetry report number 94 Organocatalytic enantioselective multicomponent reactions (OEMCRs) , 2007 .

[31]  Xinhong Yu,et al.  Organocatalysis: asymmetric cascade reactions catalysed by chiral secondary amines. , 2008, Organic & biomolecular chemistry.

[32]  Gang Zhao,et al.  Enantioselective synthesis of multifunctionalized 4H-pyran derivatives using bifunctional thiourea-tertiary amine catalysts , 2009 .

[33]  L. Tang,et al.  Asymmetric organic catalysis with modified cinchona alkaloids. , 2004, Accounts of chemical research.

[34]  S. Benetti,et al.  Convenient ‘one-pot’ synthesis of 3,4-substituted tetrahydrothiophenes through tandem Michael–Henry and Michael–Michael reactions , 2006 .

[35]  Jun Wang,et al.  Catalytic, asymmetric Michael reactions of cyclic diketones with beta,gamma-unsaturated alpha-ketoesters. , 2009, Organic letters.

[36]  D. Dixon,et al.  Enantioselective Brønsted acid-catalyzed N-acyliminium cyclization cascades. , 2009, Journal of the American Chemical Society.

[37]  C. Zhao,et al.  Organocatalytic Highly Enantioselective Tandem Michael-Knoevenagel Reaction for the Synthesis of Substituted Thiochromanes. , 2008, Tetrahedron letters.

[38]  S. Tsogoeva.  Recent Advances in Asymmetric Organocatalytic 1,4‐Conjugate Additions , 2007 .

[39]  Y. Takemoto,et al.  Recognition and activation by ureas and thioureas: stereoselective reactions using ureas and thioureas as hydrogen-bonding donors. , 2005, Organic & biomolecular chemistry.

[40]  Jian Wang,et al.  Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction. , 2005, Organic letters.

[41]  P. Balaram,et al.  Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system , 1981 .

[42]  D. Dooley,et al.  Mechanism-based cofactor derivatization of a copper amine oxidase by a branched primary amine recruits the oxidase activity of the enzyme to turn inactivator into substrate. , 2006, Journal of the American Chemical Society.

[43]  De‐Xian Wang,et al.  Brønsted acid catalyzed enantioselective three-component reaction involving the alpha addition of isocyanides to imines. , 2009, Angewandte Chemie.

[44]  Y. Takemoto,et al.  Bifunctional thiourea-catalyzed enantioselective double Michael reaction of γ,δ-unsaturated β-ketoester to nitroalkene: asymmetric synthesis of (−)-epibatidine , 2004 .

[45]  P. Schreiner.  Metal-free organocatalysis through explicit hydrogen bonding interactions. , 2003, Chemical Society reviews.

[46]  K. Jørgensen,et al.  Asymmetric synthesis of highly functionalized tetrahydrothiophenes by organocatalytic domino reactions. , 2006, Journal of the American Chemical Society.

[47]  Alessandro Massi,et al.  Asymmetric organocatalysis: from infancy to adolescence. , 2008, Angewandte Chemie.

[48]  Yi-Ju Cao,et al.  A new entry to cascade organocatalysis: reactions of stable sulfur ylides and nitroolefins sequentially catalyzed by thiourea and DMAP. , 2008, Journal of the American Chemical Society.

[49]  Jian Wang,et al.  Cascade Michael--aldol reactions promoted by hydrogen bonding mediated catalysis. , 2007, Journal of the American Chemical Society.

[50]  Wolfgang H. B. Sauer,et al.  Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity , 2003, J. Chem. Inf. Comput. Sci..

[51]  Jian Zhou,et al.  Organocatalytic asymmetric reaction cascade to substituted cyclohexylamines. , 2007, Journal of the American Chemical Society.

[52]  Stuart L Schreiber,et al.  A planning strategy for diversity-oriented synthesis. , 2004, Angewandte Chemie.

[53]  S. Schreiber,et al.  Target-oriented and diversity-oriented organic synthesis in drug discovery. , 2000, Science.

[54]  D. Enders,et al.  Asymmetric Michael Additions to Nitroalkenes , 2002 .

[55]  A. Csámpai,et al.  Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts. , 2005, Organic letters.

[56]  H. Pellissier.  Dynamic Kinetic Resolution , 2003 .

[57]  P. Schreiner,et al.  (Thio)urea organocatalysis--what can be learnt from anion recognition? , 2009, Chemical Society reviews.

[58]  Hao Li,et al.  Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to β-Nitrostyrenes. , 2006 .

[59]  Weiqi Wang,et al.  Organocatalytic Enantioselective Conjugate Additions of Heteroatoms to α,βUnsaturated Carbonyl Compounds , 2010 .

[60]  D. Enders,et al.  Asymmetric organocatalytic domino reactions. , 2007, Angewandte Chemie.

[61]  Anang A Shelat,et al.  Scaffold composition and biological relevance of screening libraries. , 2007, Nature chemical biology.

[62]  Y. Takemoto,et al.  Enantioselective tandem michael reaction to nitroalkene catalyzed by bifunctional thiourea : total synthesis of (-)-epibatidine , 2006 .

[63]  T. Akiyama,et al.  Chiral Brønsted acid-catalyzed inverse electron-demand aza Diels-Alder reaction. , 2006, Journal of the American Chemical Society.

[64]  T. Akiyama,et al.  Chiral Brønsted acid catalyzed enantioselective aza-Diels-Alder reaction of Brassard's diene with imines. , 2006, Angewandte Chemie.

[65]  L. Overman,et al.  A New Method for Stereocontrolled Synthesis of Substituted Tetrahydrothiophenes , 2000 .

[66]  Yi Wang,et al.  Dual-function cinchona alkaloid catalysis: catalytic asymmetric tandem conjugate addition-protonation for the direct creation of nonadjacent stereocenters. , 2006, Journal of the American Chemical Society.

[67]  K. Nambiar,et al.  Asymmetric total synthesis of erythromycin. 3. Total synthesis of erythromycin , 1981 .

[68]  Le Li,et al.  Catalytic enantioselective synthesis of alpha,beta-diamino acid derivatives. , 2009, Journal of the American Chemical Society.

[69]  C. Zhao,et al.  Organocatalyzed enantioselective synthesis of 6-amino-5-cyanodihydropyrano[2,3-c]pyrazoles. , 2009, Tetrahedron letters.

[70]  Y. Takemoto,et al.  Enantioselective Michael reaction of malonates to nitroolefins catalyzed by bifunctional organocatalysts. , 2003, Journal of the American Chemical Society.

[71]  Amos B. Smith,et al.  Synthetic strategies towards the total synthesis of phyllanthocin and breynolide. Application of stereochemically linear and convergent strategies , 1999 .

[72]  Jian Wang,et al.  Organocatalytic asymmetric Michael addition of 2,4-pentandione to nitroolefins. , 2005, Organic letters.

[73]  J. Bäckvall,et al.  Racemisation in asymmetric synthesis. Dynamic kinetic resolution and related processes in enzyme and metal catalysis , 2001 .