Review: Leucocyte–endothelial cell crosstalk at the blood–brain barrier: A prerequisite for successful immune cell entry to the brain

J. Greenwood, S. J. Heasman, J. I. Alvarez, A. Prat, R. Lyck and B. Engelhardt (2011) Neuropathology and Applied Neurobiology37, 24–39
Leucocyte–endothelial cell crosstalk at the blood–brain barrier: A prerequisite for successful immune cell entry to the brain

[1]  David W. Holman,et al.  The blood-brain barrier, chemokines and multiple sclerosis. , 2011, Biochimica et biophysica acta.

[2]  A. Prat,et al.  Disruption of central nervous system barriers in multiple sclerosis. , 2011, Biochimica et biophysica acta.

[3]  B. Engelhardt,et al.  Comparison of Immortalized bEnd5 and Primary Mouse Brain Microvascular Endothelial Cells as in vitro Blood–Brain Barrier Models for the Study of T Cell Extravasation , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[4]  W. G. Kerckhoff T cell interaction with ICAM-1-deficient endothelium in vitro: transendothelial migration of different T cell populations is mediated by endothelial ICAM-1 and ICAM-2 , 2011 .

[5]  B. Engelhardt,et al.  Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood–Brain Barrier Endothelium , 2010, The Journal of Immunology.

[6]  C. Rolny,et al.  A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. , 2010, Blood.

[7]  Jan van Marle,et al.  UvA-DARE ( Digital Academic Repository ) Inside-Out Regulation of ICAM-1 Dynamics in TNF-α-Activated Endothelium , 2010 .

[8]  Michael Sixt,et al.  Breaching multiple barriers: leukocyte motility through venular walls and the interstitium , 2010, Nature Reviews Molecular Cell Biology.

[9]  D. Baker,et al.  Inflammation in neurodegenerative diseases , 2010, Immunology.

[10]  Qiu‐xia Zhang,et al.  Endothelial IQGAP1 regulates efficient lymphocyte transendothelial migration , 2009, European journal of immunology.

[11]  J. Berman,et al.  Leukocyte transmigration across the blood-brain barrier: perspectives on neuroAIDS. , 2010, Frontiers in bioscience.

[12]  N. Scolding Central nervous system vasculitis , 2009, Seminars in Immunopathology.

[13]  H. Wekerle,et al.  Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions , 2009, Nature.

[14]  R. Minshall,et al.  Filamin A regulates caveolae internalization and trafficking in endothelial cells. , 2009, Molecular biology of the cell.

[15]  P. Duquette,et al.  Preferential recruitment of interferon‐γ–expressing TH17 cells in multiple sclerosis , 2009, Annals of neurology.

[16]  C. Carman Mechanisms for transcellular diapedesis: probing and pathfinding by `invadosome-like protrusions' , 2009, Journal of Cell Science.

[17]  T. Kirchhausen,et al.  Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. , 2009, Immunity.

[18]  H. Davies,et al.  Expression of Chemokines and Their Receptors by Human Brain Endothelium: Implications for Multiple Sclerosis , 2009, Journal of neuropathology and experimental neurology.

[19]  Rakesh K. Gupta,et al.  Increased expression of ICAM-1 among symptomatic neurocysticercosis , 2009, Journal of Neuroimmunology.

[20]  P. Adamson,et al.  ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration. , 2008, Molecular biology of the cell.

[21]  B. Engelhardt Immune cell entry into the central nervous system: Involvement of adhesion molecules and chemokines , 2008, Journal of the Neurological Sciences.

[22]  A. Sonnenberg,et al.  Filamin B Mediates ICAM-1-driven Leukocyte Transendothelial Migration* , 2008, Journal of Biological Chemistry.

[23]  E. Gratton,et al.  Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms , 2008, The Journal of cell biology.

[24]  G. Newton,et al.  p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. , 2008, Blood.

[25]  D. Granger,et al.  Cell adhesion molecules and ischemic stroke , 2008, Neurological research.

[26]  E. Geisert,et al.  Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE , 2008, Neurobiology of Disease.

[27]  R. Keep,et al.  Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier , 2008, Current neuropharmacology.

[28]  G. Newton,et al.  Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. , 2008, Blood.

[29]  G. Kreitzer,et al.  Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment , 2008, The Journal of experimental medicine.

[30]  S. Ofori-Acquah,et al.  Activated leukocyte cell adhesion molecule: a new paradox in cancer. , 2008, Translational research : the journal of laboratory and clinical medicine.

[31]  Janet Liversidge,et al.  Mechanisms of leukocyte migration across the blood–retina barrier , 2008, Seminars in Immunopathology.

[32]  Danica Stanimirovic,et al.  Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system , 2008, Nature Immunology.

[33]  M. Lampugnani,et al.  Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration , 2008, Journal of Cell Science.

[34]  A. Prat,et al.  The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. , 2008, Brain : a journal of neurology.

[35]  B. Engelhardt,et al.  E- and P-Selectin Are Not Required for the Development of Experimental Autoimmune Encephalomyelitis in C57BL/6 and SJL Mice1 , 2007, The Journal of Immunology.

[36]  L. Kappos,et al.  Natalizumab: Targeting α4-Integrins in Multiple Sclerosis , 2007, Neurodegenerative Diseases.

[37]  B. Engelhardt,et al.  Therapeutic targeting of leukocyte trafficking across the blood-brain barrier. , 2007, Inflammation & allergy drug targets.

[38]  J. Greenwood,et al.  PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells2 , 2007, Journal of neurochemistry.

[39]  J. Newcombe,et al.  CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions , 2007, Journal of Neuroimmunology.

[40]  J. V. van Buul,et al.  RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration , 2007, The Journal of cell biology.

[41]  J. V. van Buul,et al.  ICAM-1-Mediated, Src- and Pyk2-Dependent Vascular Endothelial Cadherin Tyrosine Phosphorylation Is Required for Leukocyte Transendothelial Migration1 , 2007, The Journal of Immunology.

[42]  P. Hordijk,et al.  Endothelial signaling by Ig-like cell adhesion molecules. , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[43]  M. Cybulsky,et al.  Getting to the site of inflammation: the leukocyte adhesion cascade updated , 2007, Nature Reviews Immunology.

[44]  L. Rivers,et al.  Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis , 2007, Neuroscience.

[45]  R. de Martin,et al.  Resolution of inflammation: Intracellular feedback loops in the endothelium , 2007, Thrombosis and Haemostasis.

[46]  E. Kohner,et al.  Leukocytes in diabetic retinopathy. , 2007, Current diabetes reviews.

[47]  R. Klein,et al.  CXCL12 Limits Inflammation by Localizing Mononuclear Infiltrates to the Perivascular Space during Experimental Autoimmune Encephalomyelitis1 , 2006, The Journal of Immunology.

[48]  Bryan Heit,et al.  Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade , 2006, The Journal of experimental medicine.

[49]  H. Abdala-Valencia,et al.  VCAM-1 Signals Activate Endothelial Cell Protein Kinase Cα via Oxidation1 , 2006, The Journal of Immunology.

[50]  A. Duperray,et al.  Evidence of a Functional Role for Interaction between ICAM-1 and Nonmuscle α-Actinins in Leukocyte Diapedesis1 , 2006, The Journal of Immunology.

[51]  P. Duquette,et al.  Statins reduce human blood–brain barrier permeability and restrict leukocyte migration: Relevance to multiple sclerosis , 2006, Annals of neurology.

[52]  R. Keep,et al.  Effects of the Chemokine CCL2 on Blood–Brain Barrier Permeability during Ischemia–Reperfusion Injury , 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[53]  P. Kubes,et al.  Reevaluation of P-Selectin and α4 Integrin as Targets for the Treatment of Experimental Autoimmune Encephalomyelitis1 , 2006, The Journal of Immunology.

[54]  G. Turner,et al.  Human cerebral malaria and the blood-brain barrier. , 2006, International journal for parasitology.

[55]  C. Figdor,et al.  Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. , 2006, Blood.

[56]  A. Ridley,et al.  Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells. , 2006, Circulation research.

[57]  D. Toomre,et al.  Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains , 2006, Nature Cell Biology.

[58]  S. Lukehart,et al.  Biological Basis for Syphilis , 2006, Clinical Microbiology Reviews.

[59]  J. Newcombe,et al.  Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. , 2006, Brain : a journal of neurology.

[60]  Y. Tettey,et al.  High-level cerebellar expression of cytokines and adhesion molecules in fatal, paediatric, cerebral malaria , 2005, Annals of tropical medicine and parasitology.

[61]  B. Engelhardt,et al.  The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. , 2005, Trends in immunology.

[62]  G. Swart,et al.  Activated leukocyte cell adhesion molecule (ALCAM/CD166): Signaling at the divide of melanoma cell clustering and cell migration? , 2005, Cancer and Metastasis Reviews.

[63]  Y. Tettey,et al.  Cytokines and Adhesion Molecules Expression in the Brain in Human Cerebral Malaria , 2005, International journal of environmental research and public health.

[64]  M. Schwartz Faculty Opinions recommendation of Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation. , 2005 .

[65]  O. Barreiro,et al.  Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation. , 2005, Blood.

[66]  P. Hordijk,et al.  Proline-rich Tyrosine Kinase 2 (Pyk2) Mediates Vascular Endothelial-Cadherin-based Cell-Cell Adhesion by Regulating β-Catenin Tyrosine Phosphorylation* , 2005, Journal of Biological Chemistry.

[67]  P. Adamson,et al.  Pharmacological Targeting of ICAM-1 Signaling in Brain Endothelial Cells: Potential for Treating Neuroinflammation , 2005, Cellular and Molecular Neurobiology.

[68]  B. Engelhardt,et al.  Mini‐review: Transendothelial migration of leukocytes: through the front door or around the side of the house? , 2004, European journal of immunology.

[69]  C. Carman,et al.  A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them , 2004, The Journal of cell biology.

[70]  T. L. Deem,et al.  Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species. , 2004, Blood.

[71]  P. Friedl,et al.  The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism , 2004, Journal of Cell Science.

[72]  F. Sánchez‐Madrid,et al.  Relevance of CD6-Mediated Interactions in T Cell Activation and Proliferation1 , 2004, The Journal of Immunology.

[73]  C. Figdor,et al.  Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCα independently of Rho-like GTPases , 2004, Journal of Cell Science.

[74]  B. Serafini,et al.  Detection of Ectopic B‐cell Follicles with Germinal Centers in the Meninges of Patients with Secondary Progressive Multiple Sclerosis , 2004, Brain pathology.

[75]  W. Muller,et al.  Locomotion of monocytes on endothelium is a critical step during extravasation , 2004, Nature Immunology.

[76]  John G. Collard,et al.  RhoA activation promotes transendothelial migration of monocytes via ROCK , 2004, Journal of leukocyte biology.

[77]  B. Engelhardt,et al.  T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells. , 2003, Blood.

[78]  S. McQuaid,et al.  Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood–brain barrier leakage and active demyelination , 2003, The Journal of pathology.

[79]  C. Carman,et al.  Integrin avidity regulation: are changes in affinity and conformation underemphasized? , 2003, Current opinion in cell biology.

[80]  B. Engelhardt,et al.  Intracellular Domain of Brain Endothelial Intercellular Adhesion Molecule-1 Is Essential for T Lymphocyte-Mediated Signaling and Migration1 , 2003, The Journal of Immunology.

[81]  P. Hordijk,et al.  VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration. , 2003, American journal of physiology. Cell physiology.

[82]  M. Gottschalk,et al.  Up‐regulation of ICAM‐1, CD11a/CD18 and CD11c/CD18 on human THP‐1 monocytes stimulated by Streptococcus suis serotype 2 , 2003, Clinical and experimental immunology.

[83]  G. Bernardi,et al.  T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules : a critical role for P-selectin glycoprotein ligand-1 , 2003 .

[84]  P. Newman,et al.  Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology. , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[85]  R. Treisman,et al.  Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL , 2003, Cell.

[86]  P. Adamson,et al.  Lovastatin inhibits brain endothelial cell Rho‐mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[87]  S. Columba-cabezas,et al.  Lymphoid Chemokines CCL19 and CCL21 are Expressed in the Central Nervous System During Experimental Autoimmune Encephalomyelitis: Implications for the Maintenance of Chronic Neuroinflammation , 2003, Brain pathology.

[88]  P. Adamson,et al.  Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated. , 2002, Brain research. Molecular brain research.

[89]  R. Hoover,et al.  E‐selectin and ICAM‐1 are incorporated into detergent‐insoluble membrane domains following clustering in endothelial cells , 2002, FEBS letters.

[90]  B. Engelhardt,et al.  Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood‐brain barrier suggests their involvement in G‐protein‐dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis , 2002, European journal of immunology.

[91]  R. Hoover,et al.  The Src‐cortactin pathway is required for clustering of E‐selectin and ICAM‐1 in endothelial cells , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[92]  P. Kubes,et al.  Overlapping Roles of P-Selectin and α4 Integrin to Recruit Leukocytes to the Central Nervous System in Experimental Autoimmune Encephalomyelitis1 , 2002, The Journal of Immunology.

[93]  Y. Jee,et al.  Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats , 2002, Journal of Neuroimmunology.

[94]  María Yáñez-Mó,et al.  Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes , 2002, The Journal of cell biology.

[95]  A. Wierinckx,et al.  Interferon-β directly influences monocyte infiltration into the central nervous system , 2002, Journal of Neuroimmunology.

[96]  P. Adamson,et al.  Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier. , 2002, Vascular pharmacology.

[97]  T. K. van den Berg,et al.  Signal-Regulatory Protein α-CD47 Interactions Are Required for the Transmigration of Monocytes Across Cerebral Endothelium1 , 2002, The Journal of Immunology.

[98]  J. Antel,et al.  Migration of multiple sclerosis lymphocytes through brain endothelium. , 2002, Archives of neurology.

[99]  Eugene C. Butcher,et al.  Molecular Mechanisms Involved in Lymphocyte Recruitment in Inflamed Brain Microvessels: Critical Roles for P-Selectin Glycoprotein Ligand-1 and Heterotrimeric Gi-Linked Receptors1 , 2002, The Journal of Immunology.

[100]  B. Engelhardt,et al.  Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. , 2002, The Journal of clinical investigation.

[101]  B. Engelhardt,et al.  Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. , 2001, The Journal of clinical investigation.

[102]  C. Figdor,et al.  Molecular Basis for the Homophilic Activated Leukocyte Cell Adhesion Molecule (ALCAM)-ALCAM Interaction* , 2001, The Journal of Biological Chemistry.

[103]  P. Adamson,et al.  Cross-Linking of Brain Endothelial Intercellular Adhesion Molecule (ICAM)-1 Induces Association of ICAM-1 With Detergent-Insoluble Cytoskeletal Fraction , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[104]  P. Newman,et al.  Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck). , 2001, Blood.

[105]  B. Rollins,et al.  Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis , 2001, The Journal of experimental medicine.

[106]  E. Brown,et al.  Integrin-associated protein (CD47) and its ligands. , 2001, Trends in cell biology.

[107]  H. Weiner,et al.  Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2) , 2000, The Journal of experimental medicine.

[108]  J. Greenwood,et al.  ICAM-1-Coupled Cytoskeletal Rearrangements and Transendothelial Lymphocyte Migration Involve Intracellular Calcium Signaling in Brain Endothelial Cell Lines1 , 2000, The Journal of Immunology.

[109]  T. L. Deem,et al.  Lymphocyte Migration Through Monolayers of Endothelial Cell Lines Involves VCAM-1 Signaling Via Endothelial Cell NADPH Oxidase1 , 2000, The Journal of Immunology.

[110]  C. Janeway,et al.  Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment. , 2000, Brain : a journal of neurology.

[111]  B. D. de Grooth,et al.  Dynamic regulation of activated leukocyte cell adhesion molecule-mediated homotypic cell adhesion through the actin cytoskeleton. , 2000, Molecular biology of the cell.

[112]  J. Schalken,et al.  Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin. , 2000, Biochemical and biophysical research communications.

[113]  U. Dirnagl,et al.  Cerebral endothelial cells release TNF-alpha after stimulation with cell walls of Streptococcus pneumoniae and regulate inducible nitric oxide synthase and ICAM-1 expression via autocrine loops. , 1999, Journal of immunology.

[114]  B. Engelhardt,et al.  T cell interaction with ICAM-1-deficient endothelium in vitro: transendothelial migration of different T cell populations is mediated by endothelial ICAM-1 and ICAM-2. , 1999, International immunology.

[115]  W. Hickey,et al.  Leukocyte traffic in the central nervous system: the participants and their roles. , 1999, Seminars in immunology.

[116]  P. Adamson,et al.  Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway. , 1999, Journal of immunology.

[117]  M. Farooque,et al.  Expression of ICAM-1 and CD11b after experimental spinal cord injury in rats. , 1999, Journal of neurotrauma.

[118]  M. Farooque,et al.  Improved recovery after spinal cord trauma in ICAM-1 and P-selectin knockout mice. , 1999, Neuroreport.

[119]  A. Strosberg,et al.  ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells. , 1998, Journal of immunology.

[120]  U. Deutsch,et al.  T cell interaction with ICAM‐1‐deficient endothelium in vitro: essential role for ICAM‐1 and ICAM‐2 in transendothelial migration of T cells , 1998, European journal of immunology.

[121]  A. Vaheri,et al.  Association of Ezrin with Intercellular Adhesion Molecule-1 and -2 (ICAM-1 and ICAM-2) , 1998, The Journal of Biological Chemistry.

[122]  C. Brosnan,et al.  MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization study , 1998, Journal of Neuroimmunology.

[123]  B. Engelhardt,et al.  E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis. , 1997, Blood.

[124]  J. Greenwood,et al.  Factors controlling T-cell migration across rat cerebral endothelium in vitro , 1997, Journal of Neuroimmunology.

[125]  S. Bamforth,et al.  Ultrastructural analysis of interleukin-1 beta-induced leukocyte recruitment to the rat retina. , 1997, Investigative ophthalmology & visual science.

[126]  B. Trapp,et al.  Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the beta 2 integrin LFA-1 in multiple sclerosis lesions. , 1996, Journal of neuropathology and experimental neurology.

[127]  J. Bajorath,et al.  Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM. , 1996, Biochemistry.

[128]  A. Strosberg,et al.  Association of the cytoplasmic domain of intercellular-adhesion molecule-1 with glyceraldehyde-3-phosphate dehydrogenase and beta-tubulin. , 1996, European journal of biochemistry.

[129]  L. Muglia,et al.  Knockout mice. , 1996, The New England journal of medicine.

[130]  E. Connolly,et al.  Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. , 1996, The Journal of clinical investigation.

[131]  U. Dirnagl,et al.  Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis , 1995, Journal of Neuroimmunology.

[132]  J. Greenwood,et al.  Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off. , 1995, Immunology.

[133]  B. Engelhardt,et al.  Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. , 1994, The American journal of pathology.

[134]  A. Strosberg,et al.  Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells. , 1994, The Journal of biological chemistry.

[135]  J. Greenwood,et al.  The blood-retinal barrier in experimental autoimmune uveoretinitis. Leukocyte interactions and functional damage. , 1994, Laboratory investigation; a journal of technical methods and pathology.

[136]  D. Phillips,et al.  PECAM-1 is required for transendothelial migration of leukocytes , 1993, The Journal of experimental medicine.

[137]  D. Staunton,et al.  Association of intercellular adhesion molecule-1 (ICAM-1) with actin- containing cytoskeleton and alpha-actinin , 1992, The Journal of cell biology.

[138]  W. Hickey,et al.  T‐lymphocyte entry into the central nervous system , 1991, Journal of neuroscience research.

[139]  R. Sobel,et al.  Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. , 1990, The American journal of pathology.

[140]  A. Cross,et al.  Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. , 1990, Laboratory investigation; a journal of technical methods and pathology.