GDAP2 mutations implicate susceptibility to cellular stress in a new form of cerebellar ataxia

Eidhofet al. report a new subtype of autosomal recessive cerebellar ataxia caused by mutations inGDAP2, and show thatGdap2 knockdown inDrosophila recapitulates locomotor dysfunction and shortened lifespan. Susceptibility to cellular stress in theGdap2 model suggests altered stress responses as a pathological mechanism.

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