Comparative genomics: The next generation

Abstract Recent advances in human gene mapping technologies have led to increased emphasis in developing representative genetic maps for several species, particularly domestic plants and animals. These maps are being compiled with two distinct goals: to provide a resource for genetic analysis, and to help dissect the evolution of genome organization by comparing linkage relationships of homologous genes. We recently proposed a list of reference anchor loci suitable for comparative gene mapping in mammals and other vertebrate classes. The comparative anchors, which are Type I (coding gene) loci, provide a comparative framework, but the addition of Type II (microsatellite) loci is also necessary for mapping phenotypes in animal gene maps. Strategies for combining the advantages of Type I and Type II locus markers are presented with emphasis on application of these concepts to the construction of a gene map of the domestic cat.

[1]  E. Lander,et al.  A genetic linkage map of the mouse: current applications and future prospects. , 1993, Science.

[2]  S. O’Brien.  The genomics generation , 1993, Current Biology.

[3]  S. O’Brien,et al.  Dating the genetic bottleneck of the African cheetah. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[4]  J. Rine,et al.  Identification and characterization of dinucleotide repeat (CA)n markers for genetic mapping in dog. , 1993, Genomics.

[5]  Nancy A. Jenkins,et al.  Anchored reference loci for comparative genome mapping in mammals , 1993, Nature Genetics.

[6]  A. Jauch,et al.  Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[7]  D. Wildt,et al.  The effect of pre-ovulatory anaesthesia on ovulation in laparoscopically inseminated domestic cats. , 1992, Journal of reproduction and fertility.

[8]  N. Arnheim,et al.  Gene-centromere linkage mapping by PCR analysis of individual oocytes. , 1992, Genomics.

[9]  R. Hubert,et al.  Whole genome amplification from a single cell: implications for genetic analysis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[10]  H. Willard,et al.  Beta satellite DNA: characterization and localization of two subfamilies from the distal and proximal short arms of the human acrocentric chromosomes. , 1992, Genomics.

[11]  S. O’Brien,et al.  Mammalian genome mapping: lessons and prospects. , 1991, Current opinion in genetics & development.

[12]  B. Trask,et al.  Fluorescence in situ hybridization: applications in cytogenetics and gene mapping. , 1991, Trends in genetics : TIG.

[13]  Stephen J. O'Brien,et al.  Genetic Maps: Locus Maps of Complex Genomes , 1990 .

[14]  S. O’Brien,et al.  Genetic mapping in mammals: chromosome map of domestic cat. , 1982, Science.

[15]  E. P. Walker,et al.  Mammals of the World , 1965 .

[16]  D. Wildt,et al.  SUCCESSFUL INDUCTION OF OVARIAN ACTIVITY AND LAPAROSCOPIC INTRAUTERINE ARTIFICIAL INSEMINATION IN THE CHEETAH {ACINONYX JUBATUS) , 1992 .

[17]  Morizot Dc.  Use of fish gene maps to predict ancestral vertebrate genome organization. , 1990 .

[18]  S. O’Brien,et al.  Mammalian genome organization: an evolutionary view. , 1988, Annual review of genetics.

[19]  J. Womack,et al.  Gene map of the cow: conservation of linkage with mouse and man. , 1986, The Journal of heredity.