Toward the blood-borne miRNome of human diseases

In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and validated this 'miRNome' by quantitative real-time PCR. We detected consistently deregulated profiles for all tested diseases; pathway analysis confirmed disease association of the respective microRNAs. We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs.

Christina Backes | Benjamin Meder | Eckart Meese | Andreas Keller | Hans-Peter Lenhof | Philip Rosenstiel | Wolfgang Rottbauer | Andre Franke | Hugo A Katus | Markus Beier | Stefan Schreiber | Petra Leidinger | Klemens Ruprecht | Jan Haas | Cord Staehler | Almut Nebel | Britta Vogel | Gunnar Jacobs | Ioannis Amarantos | Norbert Graf | W. Rottbauer | M. Büchler | S. Schreiber | J. Hoheisel | P. Rosenstiel | Andrea S Bauer | Hans-Peter Lenhof | J. Müller-Quernheim | A. Franke | J. Werner | N. Giese | B. Wullich | J. Haas | A. Keller | H. Katus | B. Meder | V. Boisguérin | A. Elsharawy | A. Nebel | P. Leidinger | C. Backes | N. Graf | B. Keck | E. Meese | K. Ruprecht | H. Huwer | B. Vogel | M. Scheffler | J. Dietl | P. Staehler | M. Beier | J. Reichrath | G. Jacobs | T. Hackert | H. Dommisch | A. Schaefer | Hanno Huwer | Abdou ElSharawy | S. Hofmann | Andrea Bauer | Anke Wendschlag | Nathalia Giese | Christine Tjaden | Katja Ott | Jens Werner | Thilo Hackert | Junko Huebers | Henrik Dommisch | Arne Schaefer | Joachim Müller-Quernheim | Bernd Wullich | Bastian Keck | Joerg Reichrath | Sven U Jager | Peer Staehler | Valesca Boisguerin | Matthias Scheffler | Markus W Büchler | Joerg Wischhusen | Sebastian F M Haeusler | Johannes Dietl | Sylvia Hofmann | Joerg D Hoheisel | K. Ott | C. Tjaden | A. Wendschlag | Junko Huebers | I. Amarantos | Cord Staehler | Joerg Wischhusen | Sebastian Haeusler | S. Schreiber | J. Müller‐Quernheim | J. Wischhusen | Abdou Elsharawy | Valesca Boisguérin | H. Lenhof

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