Age- and gender-related differences of plasma prothrombin activity levels

Toshiyuki Sakata1, Akira Okamoto1, Takashi Morita2, Yoshihiro Kokubo3, Kiyoshi Sato1, Akira Okayama3, Hitonobu Tomoike3,Toshiyuki Miyata4 1Laboratory of Clinical Chemistry, National Cardiovascular Center, Suita, Osaka, Japan; 2Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan; 3Department of Preventive Cardiology and 4Research Institute, National Cardiovascular Center, Suita, Osaka, Japan

[1]  E. Oger,et al.  Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden , 2006, Thrombosis and Haemostasis.

[2]  R. White,et al.  Racial and gender differences in the incidence of recurrent venous thromboembolism , 2006, Thrombosis and Haemostasis.

[3]  Y. Kokubo,et al.  Genetic Risk Factors for Deep Vein Thrombosis among Japanese: Importance of Protein S K196E Mutation , 2006, International journal of hematology.

[4]  John Danesh,et al.  Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66 155 cases and 91 307 controls , 2006, The Lancet.

[5]  D. Levy,et al.  Relation of the prothrombotic state to increasing age (from the Framingham Offspring Study). , 2005, The American journal of cardiology.

[6]  K. Bauer,et al.  Assessment of Hemostatic Risk Factors in Predicting Arterial Thrombotic Events , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[7]  T. Mannami,et al.  Strong and significant relationships between aggregation of major coronary risk factors and the acceleration of carotid atherosclerosis in the general population of a Japanese city: the Suita Study. , 2000, Archives of internal medicine.

[8]  K. Mann,et al.  "Normal" thrombin generation. , 1999, Blood.

[9]  T. Morita,et al.  CA-1 method, a novel assay for quantification of normal prothrombin using a Ca2+ -dependent prothrombin activator, carinactivase-1. , 1999, Thrombosis research.

[10]  J. Gardin,et al.  Oral anticoagulation in patients with atrial fibrillation: adherence with guidelines in an elderly cohort. , 1999, The American journal of medicine.

[11]  T. Miyata,et al.  The prothrombin gene G20210A mutation is not found among Japanese patients with deep vein thrombosis and healthy individuals. , 1998, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[12]  P. Reitsma,et al.  A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. , 1996, Blood.

[13]  P M Mannucci,et al.  Hypercoagulability in centenarians: the paradox of successful aging. , 1995, Blood.

[14]  K. Kario,et al.  Suppression of plasma-activated factor VII levels by warfarin therapy. , 1995, Arteriosclerosis, thrombosis, and vascular biology.