Engineered proteins as specific binding reagents.
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[1] Alexander Kamb,et al. Transcriptional transactivation by selected short random peptides attached to lexA-GFP fusion proteins , 2001, BMC Molecular Biology.
[2] G. Caponigro,et al. Green fluorescent protein as a scaffold for intracellular presentation of peptides. , 1998, Nucleic acids research.
[3] Arne Skerra,et al. Construction of an Artificial Receptor Protein (“Anticalin”) Based on the Human Apolipoprotein D , 2004, Chembiochem : a European journal of chemical biology.
[4] M. Uhlén,et al. Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain. , 1997, Nature biotechnology.
[5] A. Skerra. Engineered protein scaffolds for molecular recognition , 2000, Journal of molecular recognition : JMR.
[6] S. Sia,et al. Protein grafting of an HIV-1-inhibiting epitope , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[7] Andreas Plückthun,et al. Intracellular Kinase Inhibitors Selected from Combinatorial Libraries of Designed Ankyrin Repeat Proteins* , 2005, Journal of Biological Chemistry.
[8] J. Fastrez,et al. TEM‐1 β‐lactamase as a scaffold for protein recognition and assay , 2002 .
[9] G. P. Smith,et al. Alpha-helically constrained phage display library. , 2002, Protein engineering.
[10] D. Missé,et al. Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes , 2003, Nature Biotechnology.
[11] Frédéric Pecorari,et al. In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein. , 2003, Biochemistry.
[12] Andreas Plückthun,et al. Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins. , 2003, Journal of molecular biology.
[13] F. Hoppe-Seyler,et al. Peptide aptamers: exchange of the thioredoxin-A scaffold by alternative platform proteins and its influence on target protein binding , 2002, Cellular and Molecular Life Sciences CMLS.
[14] Jakob Dogan,et al. Thermodynamics of folding, stabilization, and binding in an engineered protein--protein complex. , 2004, Journal of the American Chemical Society.
[15] Dan S. Tawfik,et al. Directed evolution of protein inhibitors of DNA-nucleases by in vitro compartmentalization (IVC) and nano-droplet delivery. , 2005, Journal of molecular biology.
[16] Andreas Plückthun,et al. Allosteric inhibition of aminoglycoside phosphotransferase by a designed ankyrin repeat protein. , 2005, Structure.
[17] V. Erdmann,et al. Searching sequence space for high-affinity binding peptides using ribosome display. , 2003, Journal of molecular biology.
[18] J. Thornton,et al. Smith, G.P. et al. Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage. J. Mol. Biol. 277, 317-332 , 1998 .
[19] M. Jongsma,et al. Selection by phage display of a variant mustard trypsin inhibitor toxic against aphids. , 2003, The Plant Journal.
[20] A. Lim,et al. Directed evolution of high-affinity antibody mimics using mRNA display. , 2002, Chemistry & biology.
[21] J M Thornton,et al. Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage. , 1998, Journal of molecular biology.
[22] Jakob Dogan,et al. Biophysical characterization of ZSPA‐1—A phage‐display selected binder to protein A , 2004, Protein science : a publication of the Protein Society.
[23] D. Lane,et al. Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level , 2004, British Journal of Cancer.
[24] H. Berglund,et al. An affibody in complex with a target protein: Structure and coupled folding , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[25] Fang Wang,et al. A conformation-constrained peptide library based on insect defensin A , 2004, Peptides.
[26] A. Koide,et al. Probing protein conformational changes in living cells by using designer binding proteins: Application to the estrogen receptor , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[27] S. Demo,et al. Cellular localization and antiproliferative effect of peptides discovered from a functional screen of a retrovirally delivered random peptide library. , 2003, Chemistry & biology.
[28] T. Teeri,et al. Alpha‐amylase inhibitors selected from a combinatorial library of a cellulose binding domain scaffold , 2000, Proteins.
[29] Joseph Sodroski,et al. Beta-turn Phe in HIV-1 Env binding site of CD4 and CD4 mimetic miniprotein enhances Env binding affinity but is not required for activation of co-receptor/17b site. , 2002, Biochemistry.
[30] A. Plückthun,et al. Designed to be stable: Crystal structure of a consensus ankyrin repeat protein , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[31] Philippe Minard,et al. Affinity transfer by CDR grafting on a nonimmunoglobulin scaffold , 2004, Protein science : a publication of the Protein Society.
[32] D. Gell,et al. Engineering a protein scaffold from a PHD finger. , 2003, Structure.
[33] M. Scholle,et al. Molecular recognition properties of FN3 monobodies that bind the Src SH3 domain. , 2004, Chemistry & biology.
[34] R Gallerani,et al. Functional expression on bacteriophage of the mustard trypsin inhibitor MTI-2. , 2001, Biochemical and biophysical research communications.
[35] Gianni Cesareni,et al. In Vitro Evolution of Recognition Specificity Mediated by SH3 Domains Reveals Target Recognition Rules* , 2002, The Journal of Biological Chemistry.
[36] K. Saksela,et al. Capacity of simian immunodeficiency virus strain mac Nef for high-affinity Src homology 3 (SH3) binding revealed by ligand-tailored SH3 domains. , 2002, The Journal of general virology.
[37] V. Rybin,et al. Computer-aided design of a PDZ domain to recognize new target sequences , 2002, Nature Structural Biology.
[38] I. Korndörfer,et al. Crystallographic analysis of an “anticalin” with tailored specificity for fluorescein reveals high structural plasticity of the lipocalin loop region , 2003, Proteins.
[39] A. Plückthun,et al. A novel strategy to design binding molecules harnessing the modular nature of repeat proteins , 2003, FEBS letters.
[40] A. Koide,et al. The fibronectin type III domain as a scaffold for novel binding proteins. , 1998, Journal of molecular biology.
[41] Yi Li,et al. Directed evolution of human T-cell receptors with picomolar affinities by phage display , 2005, Nature Biotechnology.
[42] Tristan J. Vaughan,et al. Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library , 1996, Nature Biotechnology.
[43] W. DeGrado,et al. Evolution of binding affinity in a WW domain probed by phage display , 2000, Protein science : a publication of the Protein Society.
[44] A. Plückthun,et al. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides. , 2000, Journal of molecular biology.
[45] T R Hughes,et al. Genetic selection of peptide inhibitors of biological pathways. , 1999, Science.
[46] Andreas Plückthun,et al. Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering. , 2004, Methods.
[47] A. Plückthun,et al. High-affinity binders selected from designed ankyrin repeat protein libraries , 2004, Nature Biotechnology.
[48] E. Karlsson,et al. A carbohydrate binding module as a diversity-carrying scaffold. , 2004, Protein engineering, design & selection : PEDS.
[49] A. Cattaneo,et al. Intracellular antibodies for proteomics☆ , 2004, Journal of Immunological Methods.
[50] P. Nygren,et al. Binding proteins from alternative scaffolds. , 2004, Journal of immunological methods.
[51] Tommi Kajander,et al. Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins. , 2004, Protein engineering, design & selection : PEDS.
[52] P. Nordlund,et al. Structural basis for recognition by an in vitro evolved affibody , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[53] M. Price,et al. Synthesis and antibody recognition of mucin 1 (MUC1)-alpha-conotoxin chimera. , 2000, Journal of peptide science : an official publication of the European Peptide Society.
[54] J. Desmet,et al. Development and application of cytotoxic T lymphocyte‐associated antigen 4 as a protein scaffold for the generation of novel binding ligands , 2000, FEBS letters.
[55] J. Sodroski,et al. Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic. , 1999, Biochemistry.
[56] A. Folgori,et al. A conformationally homogeneous combinatorial peptide library. , 1995, Journal of molecular biology.
[57] K. Saksela,et al. Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains. , 2001, Virology.
[58] Malin M. Young,et al. Computer-assisted Mutagenesis of Ecotin to Engineer Its Secondary Binding Site for Urokinase Inhibition* , 2002, The Journal of Biological Chemistry.
[59] G. Adams,et al. Selection and characterization of HER2/neu-binding affibody ligands. , 2004, Protein engineering, design & selection : PEDS.
[60] C Li,et al. Phage randomization in a charybdotoxin scaffold leads to CD4-mimetic recognition motifs that bind HIV-1 envelope through non-aromatic sequences. , 2001, The journal of peptide research : official journal of the American Peptide Society.
[61] C. Craik,et al. Engineering of a macromolecular scaffold to develop specific protease inhibitors , 2003, Nature Biotechnology.
[62] C. Vita,et al. Novel miniproteins engineered by the transfer of active sites to small natural scaffolds. , 1998, Biopolymers.
[63] Z. Xu,et al. Inhibition of the CD28-CD80 co-stimulation signal by a CD28-binding affibody ligand developed by combinatorial protein engineering. , 2003, Protein engineering.
[64] C. Hovens,et al. Mutagenesis and selection of PDZ domains that bind new protein targets , 1999, Nature Biotechnology.
[65] E. Auerswald,et al. Functional phage display of leech‐derived tryptase inhibitor (LDTI): construction of a library and selection of thrombin inhibitors , 1999, FEBS letters.
[66] Andreas Plückthun,et al. Designing repeat proteins: modular leucine-rich repeat protein libraries based on the mammalian ribonuclease inhibitor family. , 2003, Journal of molecular biology.
[67] M. Billeter,et al. MOLMOL: a program for display and analysis of macromolecular structures. , 1996, Journal of molecular graphics.
[68] R. Hodges,et al. Use of a conformationally restricted secondary structural element to display peptide libraries: a two-stranded alpha-helical coiled-coil stabilized by lactam bridges. , 1996, Journal of molecular biology.
[69] P. Colas. Combinatorial protein reagents to manipulate protein function. , 2000, Current opinion in chemical biology.
[70] A. Plückthun,et al. New protein engineering approaches to multivalent and bispecific antibody fragments. , 1997, Immunotechnology : an international journal of immunological engineering.
[71] A. Tanaka,et al. Evaluation of phage display system and leech-derived tryptase inhibitor as a tool for understanding the serine proteinase specificities. , 2004, Archives of biochemistry and biophysics.
[72] I. Korndörfer,et al. Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin. , 2003, Journal of molecular biology.
[73] Jacques Fastrez,et al. Engineering of non-natural receptors. , 2004, Current opinion in structural biology.
[74] D. Payan,et al. Characterization and Use of Green Fluorescent Proteins from Renilla mulleri and Ptilosarcus guernyi for the Human Cell Display of Functional Peptides , 2001, Journal of protein chemistry.
[75] Matthew R. Clutter,et al. High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3. , 2005, Journal of molecular biology.
[76] Richard W Roberts,et al. Identification of epitope‐like consensus motifs using mRNA display , 2002, Journal of molecular recognition : JMR.
[77] Renhao Li,et al. Use of phage display to probe the evolution of binding specificity and affinity in integrins. , 2003, Protein engineering.
[78] J. Sedivy,et al. Random mutagenesis of PDZOmi domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis , 2003, Oncogene.
[79] Pier Paolo Di Fiore,et al. A repertoire library that allows the selection of synthetic SH2s with altered binding specificities , 2001, Oncogene.
[80] Arne Skerra,et al. Lipocalins in drug discovery: from natural ligand-binding proteins to "anticalins". , 2005, Drug discovery today.
[81] C. Vita,et al. Synthesis and immunological studies of alpha-conotoxin chimera containing an immunodominant epitope from the 268-284 region of HSV gD protein. , 2000, The journal of peptide research : official journal of the American Peptide Society.
[82] M. Uhlén,et al. Binding proteins selected from combinatorial libraries of an α-helical bacterial receptor domain , 1997, Nature Biotechnology.