Photodynamic effect in near-IR light by a photocytotoxic iron(III) cellular imaging agent.

A red light for cancer cells: an iron(III) complex (1, see picture) that contains an anthracenyl fluorophore moiety and a catecholate ligand is a potent, metal-based PDT agent that efficiently photocleaves DNA in near-infrared light, has significant nuclear uptake, and high photocytotoxicity in red light by an apoptotic pathway in HeLa and MCF-7 cancer cells.

[1]  P. Sadler,et al.  A potent cytotoxic photoactivated platinum complex , 2007, Proceedings of the National Academy of Sciences.

[2]  K. Szaciłowski,et al.  Bioinorganic photochemistry: frontiers and mechanisms. , 2005, Chemical reviews.

[3]  Kim R Dunbar,et al.  Interactions of metal-metal-bonded antitumor active complexes with DNA fragments and DNA. , 2005, Accounts of chemical research.

[4]  Jan Reedijk,et al.  The Square-Planar Cytotoxic [CuII(pyrimol)Cl] Complex Acts as an Efficient DNA Cleaver without Reductant , 2006 .

[5]  E. Suresh,et al.  Iron(III) complexes of tridentate 3N ligands as functional models for catechol dioxygenases: the role of ligand N-alkyl substitution and solvent on reaction rate and product selectivity. , 2007, Inorganic chemistry.

[6]  P. Sadler,et al.  A potent trans-diimine platinum anticancer complex photoactivated by visible light. , 2010, Angewandte Chemie.

[7]  M. Pink,et al.  Elucidation of the extraordinary 4-membered pyrrole ring-contracted azeteoporphyrinoid as an intermediate in chlorin oxidation. , 2006, Chemical communications.

[8]  J. Barton,et al.  DNA mismatch binding and antiproliferative activity of rhodium metalloinsertors. , 2009, Journal of the American Chemical Society.

[9]  M. Palaniandavar,et al.  Mononuclear iron(III) complexes of 3N ligands in organized assemblies: spectral and redox properties and attainment of regioselective extradiol dioxygenase activity. , 2011, Dalton transactions.

[10]  D. D. De Vos,et al.  A comparative study of the photosensitizing characteristics of some cyanine dyes. , 2000, Journal of photochemistry and photobiology. B, Biology.

[11]  U. Schatzschneider.  Photoactivated Biological Activity of Transition‐Metal Complexes , 2010 .

[12]  A. Spek,et al.  Iron(III)-catecholato complexes as structural and functional models of the intradiol-cleaving catechol dioxygenases. , 2007, Inorganic chemistry.

[13]  Tayyaba Hasan,et al.  Imaging and photodynamic therapy: mechanisms, monitoring, and optimization. , 2010, Chemical reviews.

[14]  C. Che,et al.  Highly cytotoxic iron(II) complexes with pentadentate pyridyl ligands as a new class of anti-tumor agents. , 2005, Chemical communications.

[15]  C. Burrows,et al.  Oxidative Nucleobase Modifications Leading to Strand Scission. , 1998, Chemical reviews.

[16]  Alexis D. Ostrowski,et al.  Metal complexes as photochemical nitric oxide precursors: potential applications in the treatment of tumors. , 2009, Dalton transactions.

[17]  P. Sadler,et al.  Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine. , 2009, Dalton transactions.

[18]  S. Moriwaki,et al.  Analysis of photosensitivity in Japanese cancer‐bearing patients receiving photodynamic therapy with porfimer sodium (PhotofrinTM) , 2001, Photodermatology, photoimmunology & photomedicine.

[19]  Raymond Bonnett,et al.  Chemical Aspects of Photodynamic Therapy , 2000 .

[20]  J. Sessler,et al.  Texaphyrins: new drugs with diverse clinical applications in radiation and photodynamic therapy. , 2000, Biochemical pharmacology.

[21]  P. Mascharak,et al.  Photoactive ruthenium nitrosyls as NO donors: how to sensitize them toward visible light. , 2011, Accounts of chemical research.

[22]  R. Dighe,et al.  An iron complex of dipyridophenazine as a potent photocytotoxic agent in visible light. , 2009, Inorganic chemistry.

[23]  R. Dighe,et al.  Ferrocene-Promoted Photoactivated DNA Cleavage and Anticancer Activity of Terpyridyl Copper(II) Phenanthroline Complexes , 2010 .

[24]  R. Dighe,et al.  Oxovanadium(IV)-based near-IR PDT agents: design to biological evaluation. , 2009, Chemical communications.

[25]  C. Turro,et al.  Dirhodium(II,II) complexes: molecular characteristics that affect in vitro activity. , 2006, Journal of medicinal chemistry.

[26]  B. Winkel,et al.  A new Os,Rh bimetallic with O2 independent DNA cleavage and DNA photobinding with red therapeutic light excitation. , 2011, Chemical communications.