Developmental Regulation of the Cell Division Protein FtsZ in Anabaena sp. Strain PCC 7120, a Cyanobacterium Capable of Terminal Differentiation

ABSTRACT Heterocysts are terminally differentiated cells devoted to nitrogen fixation in the filamentous cyanobacterium Anabaena sp. strain PCC 7120. We show here that the cell division protein FtsZ is present in vegetative cells but undetectable in heterocysts. These results provide a first rational explanation for the inability of mature heterocysts to undergo cell division.

[1]  F. Kawamura,et al.  The Lethal Effect of a Benzamide Derivative, 3-Methoxybenzamide, Can Be Suppressed by Mutations within a Cell Division Gene, ftsZ, in Bacillus subtilis , 1999, Journal of bacteriology.

[2]  C.-C. Zhang,et al.  Cloning and characterisation of the pknD gene encoding an eukaryotic-type protein kinase in the cyanobacterium Anabaena sp. PCC7120 , 1998, Molecular and General Genetics MGG.

[3]  Y. Brun,et al.  Cell cycle-dependent transcriptional and proteolytic regulation of FtsZ in Caulobacter. , 1998, Genes & development.

[4]  A. Khvorova,et al.  The spoIIE Locus Is Involved in the Spo0A-Dependent Switch in the Location of FtsZ Rings inBacillus subtilis , 1998, Journal of bacteriology.

[5]  Nanne Nanninga,et al.  Morphogenesis of Escherichia coli , 1998, Microbiology and Molecular Biology Reviews.

[6]  J. Lutkenhaus,et al.  Dynamic assembly of FtsZ regulated by GTP hydrolysis , 1998, The EMBO journal.

[7]  M. Houghton,et al.  Heterocyst Pattern Formation Controlled by a Diffusible Peptide , 1998 .

[8]  G M Rubin,et al.  Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. , 1998, Development.

[9]  L. Rothfield,et al.  Bacterial Cell Division: The Cycle of the Ring , 1997, Cell.

[10]  D. Bramhill,et al.  Bacterial cell division. , 1997, Annual review of cell and developmental biology.

[11]  J. Lutkenhaus,et al.  Bacterial cell division and the Z ring. , 1997, Annual review of biochemistry.

[12]  B. Edgar,et al.  Developmental Control of Cell Cycle Regulators: A Fly's Perspective , 1996, Science.

[13]  Y. Brun,et al.  Cell cycle regulation and cell type-specific localization of the FtsZ division initiation protein in Caulobacter. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[14]  J. Nevins,et al.  Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. , 1996, Genes & development.

[15]  R. Losick,et al.  Transcription factor Spo0A switches the localization of the cell division protein FtsZ from a medial to a bipolar pattern in Bacillus subtilis. , 1996, Genes & development.

[16]  C. Wolk,et al.  Heterocyst formation. , 1996, Annual review of genetics.

[17]  D. G. Adams,et al.  Cloning and sequence of ftsZ and flanking regions from the cyanobacterium Anabaena PCC 7120. , 1995, Gene.

[18]  A. Friry,et al.  Analysis of genes encoding the cell division protein FtsZ and a glutathione synthetase homologue in the cyanobacterium Anabaena sp. PCC 7120. , 1995, Research in microbiology.

[19]  A. Ernst,et al.  Heterocyst Metabolism and Development , 1994 .

[20]  C. Zhang A gene encoding a protein related to eukaryotic protein kinases from the filamentous heterocystous cyanobacterium Anabaena PCC 7120. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[21]  R. Haselkorn,et al.  Molecular Genetics of Cyanobacterial Development , 1993 .

[22]  J. Corbo,et al.  Cloning and characterization of a Rhizobium meliloti homolog of the Escherichia coli cell division gene ftsZ , 1991, Journal of bacteriology.

[23]  M. Aldea,et al.  Preferential cytoplasmic location of FtsZ, a protein essential for Escherichia coli septation , 1991, Molecular Microbiology.

[24]  J. Lutkenhaus,et al.  FtsZ in Bacillus subtilis is required for vegetative septation and for asymmetric septation during sporulation. , 1991, Genes & development.

[25]  C. Wolk,et al.  Developmental regulation and spatial pattern of expression of the structural genes for nitrogenase in the cyanobacterium Anabaena. , 1990, The EMBO journal.

[26]  J. Lutkenhaus,et al.  Overproduction of FtsZ induces minicell formation in E. coli , 1985, Cell.

[27]  Robert Haselkorn,et al.  Rearrangement of nitrogen fixation genes during heterocyst differentiation in the cyanobacterium Anabaena , 1985, Nature.

[28]  J. Waterbury,et al.  Generic assignments, strain histories, and properties of pure cultures of cyanobacteria , 1979 .

[29]  M Wilcox,et al.  Pattern formation in the blue-green alga Anabaena. II. Controlled proheterocyst regression. , 1973, Journal of cell science.