Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect.
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F. Setién | M. Urioste | J. Benítez | M. Esteller | A. Monteiro | A. Osorio | D. Megías | Nicholas T. Woods | J. Macías | A. Barroso | Tereza Vaclová | S. Gómez-López | J. M. García Bueno | Sergio Gómez-López | A. Monteiro