Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells.

[1]  D. Philpott,et al.  NOD2 modulates immune tolerance via the GM-CSF–dependent generation of CD103+ dendritic cells , 2020, Proceedings of the National Academy of Sciences.

[2]  Morag Park,et al.  Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis , 2020, Protein & Cell.

[3]  Xinliang Pan,et al.  Autophagy inhibition induces the repolarisation of tumour-associated macrophages and enhances chemosensitivity of laryngeal cancer cells to cisplatin in mice , 2019, Cancer Immunology, Immunotherapy.

[4]  J. Maurel,et al.  The Tumor Microenvironment in Colorectal Cancer Therapy , 2019, Cancers.

[5]  D. Philpott,et al.  Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models. , 2019, Cell reports.

[6]  T. Denning,et al.  Early-Life Microbiota Exposure Restricts Myeloid-Derived Suppressor Cell–Driven Colonic Tumorigenesis , 2019, Cancer Immunology Research.

[7]  P. Hammerman,et al.  Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity , 2019, Journal of Immunotherapy for Cancer.

[8]  R. Germain,et al.  A sustained small increase in NOD1 expression promotes ligand-independent oncogenic activity , 2019, bioRxiv.

[9]  Ping-Tzu Chen,et al.  Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages , 2018, Journal of experimental & clinical cancer research : CR.

[10]  B. Strooper,et al.  Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis , 2018, Cell.

[11]  H. Gogas,et al.  Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells , 2018, The Journal of clinical investigation.

[12]  Ping Wang,et al.  Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression , 2018, The Journal of experimental medicine.

[13]  Ran Blekhman,et al.  Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment , 2018, PLoS genetics.

[14]  K. McCoy,et al.  Inflammasomes make the case for littermate-controlled experimental design in studying host-microbiota interactions , 2018, Gut microbes.

[15]  Xiaoyu Liang,et al.  Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype , 2018, Nature Communications.

[16]  S. Rivest,et al.  Triggering of NOD2 Receptor Converts Inflammatory Ly6Chigh into Ly6Clow Monocytes with Patrolling Properties. , 2017, Cell reports.

[17]  M. Mann,et al.  L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity , 2016, Cell.

[18]  Peter J. Murray,et al.  Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards , 2016, Nature Communications.

[19]  Ji-Young Kim,et al.  Impaired macrophage autophagy induces systemic insulin resistance in obesity , 2016, Oncotarget.

[20]  Grace Y Chen,et al.  Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-γ Production , 2016, The Journal of Immunology.

[21]  J. Ting,et al.  Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components , 2015, Oncotarget.

[22]  D. Ferguson,et al.  Autophagy Controls Acquisition of Aging Features in Macrophages , 2015, Journal of Innate Immunity.

[23]  M. Bissonnette,et al.  The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon , 2015, Gut.

[24]  Jiang Li,et al.  Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer , 2015, Journal of Translational Medicine.

[25]  M. Czaja,et al.  Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization , 2015, Autophagy.

[26]  G. Cline,et al.  Functional polarization of tumour-associated macrophages by tumour-derived lactic acid , 2014, Nature.

[27]  R. Weinberg,et al.  The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis , 2014, Nature Cell Biology.

[28]  F. Geissmann,et al.  Constant replenishment from circulating monocytes maintains the macrophage pool in adult intestine , 2014, Nature Immunology.

[29]  Maxim N. Artyomov,et al.  Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation , 2014, Nature Immunology.

[30]  G. Friedlander,et al.  Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis. , 2014, Immunity.

[31]  J. Bertin,et al.  The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling. , 2014, Cell host & microbe.

[32]  K. Matsushima,et al.  Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes , 2014, Proceedings of the National Academy of Sciences.

[33]  D. Quail,et al.  Microenvironmental regulation of tumor progression and metastasis , 2014 .

[34]  Dudley Lamming,et al.  The TSC-mTOR pathway regulates macrophage polarization , 2013, Nature Communications.

[35]  M. Meyerson,et al.  Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. , 2013, Cell host & microbe.

[36]  D. Philpott,et al.  Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis , 2013, Gut microbes.

[37]  H. Lei,et al.  TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation , 2012, Cell Death and Differentiation.

[38]  H. Lei,et al.  Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation , 2013, Autophagy.

[39]  R. Sandler,et al.  Fusobacterium Is Associated with Colorectal Adenomas , 2013, PloS one.

[40]  P. Bonaldo,et al.  Role of macrophage polarization in tumor angiogenesis and vessel normalization: implications for new anticancer therapies. , 2013, International review of cell and molecular biology.

[41]  Douglas Hanahan,et al.  Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment Prospects and Obstacles for Therapeutic Targeting of Function-enabling Stromal Cell Types , 2022 .

[42]  B. Birren,et al.  Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. , 2012, Genome research.

[43]  Richard A. Moore,et al.  Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. , 2012, Genome research.

[44]  Daniel G. Anderson,et al.  Origins of tumor-associated macrophages and neutrophils , 2012, Proceedings of the National Academy of Sciences.

[45]  M. Sporn,et al.  Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice. , 2011, The Journal of clinical investigation.

[46]  T. Mak,et al.  Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation , 2011, Proceedings of the National Academy of Sciences.

[47]  Werner Müller,et al.  Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. , 2011, Immunity.

[48]  S. Ziegler,et al.  Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation. , 2010, The Journal of allergy and clinical immunology.

[49]  C. Streutker,et al.  Nod1 and Nod2 Regulation of Inflammation in the Salmonella Colitis Model , 2010, Infection and Immunity.

[50]  Leonore A. Herzenberg,et al.  Two physically, functionally, and developmentally distinct peritoneal macrophage subsets , 2010, Proceedings of the National Academy of Sciences.

[51]  D. Philpott,et al.  Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry , 2010, Nature Immunology.

[52]  D. Čiháková,et al.  Alternatively activated macrophages in infection and autoimmunity. , 2009, Journal of autoimmunity.

[53]  S. Biswas,et al.  Endotoxin tolerance: new mechanisms, molecules and clinical significance. , 2009, Trends in immunology.

[54]  S. Girardin,et al.  Unleashing the therapeutic potential of NOD-like receptors , 2009, Nature Reviews Drug Discovery.

[55]  Srinivas Nagaraj,et al.  Myeloid-derived suppressor cells as regulators of the immune system , 2009, Nature Reviews Immunology.

[56]  Gabriel Núñez,et al.  The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. , 2008, Cancer research.

[57]  D. Philpott,et al.  Nod2-Dependent Th2 Polarization of Antigen-Specific Immunity1 , 2008, The Journal of Immunology.

[58]  Michelle Collazo,et al.  Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice1 , 2008, The Journal of Immunology.

[59]  D. Gilroy,et al.  Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP , 2008, Blood.

[60]  M. Nishimura,et al.  Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy , 2008, Cancer Immunology, Immunotherapy.

[61]  K. Gupta,et al.  Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer , 2007, Nature Medicine.

[62]  D. Philpott,et al.  Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. , 2007, Immunity.

[63]  T. Senda,et al.  Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia , 2007, Medical Molecular Morphology.

[64]  J. Hasday,et al.  Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. , 2006 .

[65]  J. Bertin,et al.  Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin , 2005, EMBO reports.

[66]  Richard A. Flavell,et al.  Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract , 2005, Science.

[67]  S. Okada,et al.  Synsthesis and RES-stimulating activity of bacterial cell-wall peptidoglycan peptides related to FK-156 , 1982, Experientia.

[68]  J. Brayer,et al.  Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses , 2004, Cancer Research.

[69]  P. Murray,et al.  Enhancer-Mediated Control of Macrophage-Specific Arginase I Expression1 , 2004, The Journal of Immunology.

[70]  D. Philpott,et al.  Peptidoglycan Molecular Requirements Allowing Detection by Nod1 and Nod2* , 2003, Journal of Biological Chemistry.

[71]  S. Foster,et al.  An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid , 2003, Nature Immunology.

[72]  J. Bertin,et al.  Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan , 2003, Science.

[73]  M. Chamaillard,et al.  Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection* , 2003, The Journal of Biological Chemistry.

[74]  S. Foster,et al.  Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2 , 2003, The Journal of Biological Chemistry.

[75]  M. Colombo,et al.  IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice1 , 2003, The Journal of Immunology.

[76]  S. Gordon.  Alternative activation of macrophages , 2003, Nature Reviews Immunology.

[77]  Marina A Dobrovolskaia,et al.  Toll receptors, CD14, and macrophage activation and deactivation by LPS. , 2002, Microbes and infection.

[78]  J. Bertin,et al.  CARD4/Nod1 mediates NF‐κB and JNK activation by invasive Shigella flexneri , 2001 .

[79]  L. del Peso,et al.  Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB* , 1999, The Journal of Biological Chemistry.

[80]  K. Kinzler,et al.  Erratum: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene , 1992, Science.

[81]  H. Pitot,et al.  A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. , 1990, Science.

[82]  M. Nishida,et al.  Immunoactive peptides, FK-156 and FK-565. III. Enhancement of host defense mechanisms against infection. , 1983, The Journal of antibiotics.

[83]  M. Nishida,et al.  Immunoactive peptides, FK-156 and FK-565. I. Enhancement of host resistance to microbial infection in mice. , 1983, The Journal of antibiotics.

[84]  J. Čapková,et al.  Opposite effects of the synthetic immunodulator, muramyl dipeptide, on rejection of mouse skin allografts , 1983, European journal of immunology.

[85]  C. Leclerc,et al.  Demonstration of muramyl dipeptide (MDP)‐induced T suppressor cells responsible for MDP immunosuppressive activity , 1982, European journal of immunology.

[86]  V. Souvannavong,et al.  Opposite effects of the synthetic adjuvant N‐acetyl‐muramyl‐L‐alanyl‐D‐isoglutamine on the immune response in mice depending on experimental conditions , 1980, European journal of immunology.