Correlation Between 25-Hydroxy-Vitamin D and Parkinson's Disease: A Case-Control Study

Background: Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25- hydroxy vitamin D (25(OH)D) concentrations than controls. whether the research in other regions �ndings are generalizable to China populations remains untested in other studies. In this case-control study we examined the Correlation between 25-hydroxy-vitamin D and Parkinson's disease. Methods: We establish an association between de�ciency of 25-hydroxy-vitamin D and PD in a case-control study of 100 PD patients and 100 control subjects free of neurologic disease in the First A�iated Hospital of Xinjiang Medical University. Results: Total 25-hydroxy-vitamin D levels, were de�cient in 21% of patients with PD compared with 4% of controls. In univariate analyses Plasma levels of 25-hydroxy-vitamin D were associated with PD(p<0.001), respectively. In multivariate analyses, Vitamin D de�ciency(25(OH)D <20 ng/mL) were signi�cant associated with PD (p=0.008,OR=17.13,95% CI, 2.082-141.075). Individuals with levels in the lowest quartile of 25(OH)D values had the highest prevalence of PD(p =0.026,OR=11.786,95%CI,1.342-103.51)compared with individuals with values in the highest quartile. Conclusions: Our study reveals an association between 25-hydroxy-vitamin D and PD.Patients with incident PD had signi�cantly lower serum 25(OH)D concentrations than age-matched controls, High-risk PD patients with vitamin D de�ciency who have not yet developed exercise impairment, these populations should undergo vitamin D measurement and vitamin D treatment as soon as possible.