Microglial exosomes alleviate intermittent hypoxia-induced cognitive deficits by suppressing NLRP3 inflammasome

[1]  S. Fusco,et al.  Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic molecules , 2022, Translational Neurodegeneration.

[2]  Tuan Leng Tay,et al.  Microglia states and nomenclature: A field at its crossroads , 2022, Neuron.

[3]  Yanchuan Shi,et al.  Research progress on the role of exosomes in obstructive sleep apnea-hypopnea syndrome-related atherosclerosis. , 2022, Sleep medicine reviews.

[4]  Jin Tan,et al.  PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in Albumin Overload-Induced Renal Tubular Cell Injury. , 2022, Frontiers in bioscience.

[5]  J. Troncoso,et al.  Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease , 2022, Neuron.

[6]  H. Kazan,et al.  miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages , 2022, Circulation research.

[7]  Ashok K Shetty,et al.  Can mild cognitive impairment and Alzheimer’s disease be diagnosed by monitoring a miRNA triad in the blood? , 2022, Aging cell.

[8]  Xiaoyan Yang,et al.  Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer’s Disease Through the PINK1/Parkin Pathway , 2022, Frontiers in Cellular Neuroscience.

[9]  E. López-Collazo,et al.  Inflammasome Activation: A Keystone of Proinflammatory Response in Obstructive Sleep Apnea. , 2022, American journal of respiratory and critical care medicine.

[10]  Zijing Yang,et al.  Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice via Augmenting Nrf2 Nuclear Translocation and Autophagy , 2022, Frontiers in Cellular Neuroscience.

[11]  Qiang Liu,et al.  Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation , 2022, Frontiers in Neuroscience.

[12]  N. Chowdhury,et al.  Intermittent hypoxia and sleep disruption in obstructive sleep apnea increase serum tau and amyloid‐beta levels , 2022, Journal of sleep research.

[13]  W. Yeh,et al.  Regulatory Effects of Quercetin on M1/M2 Macrophage Polarization and Oxidative/Antioxidative Balance , 2021, Nutrients.

[14]  F. Kobeissy,et al.  Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms , 2021, Current neuropharmacology.

[15]  T. Schulze,et al.  A microRNA signature that correlates with cognition and is a target against cognitive decline , 2021, EMBO molecular medicine.

[16]  L. Xiong,et al.  MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of α5GABAA receptors in aged mice , 2021, Journal of Neuroinflammation.

[17]  Yizhou Xu,et al.  Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation , 2021, Neural plasticity.

[18]  Yajing Guo,et al.  Involvement of Hepcidin in Cognitive Damage Induced by Chronic Intermittent Hypoxia in Mice , 2021, Oxidative medicine and cellular longevity.

[19]  T. Maher,et al.  Enhanced IL-1β Release Following NLRP3 and AIM2 Inflammasome Stimulation Is Linked to mtROS in Airway Macrophages in Pulmonary Fibrosis , 2021, Frontiers in Immunology.

[20]  D. Holtzman,et al.  Activated microglia mitigate Aβ-associated tau seeding and spreading , 2021, The Journal of experimental medicine.

[21]  M. Bonafè,et al.  miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases , 2021, Ageing Research Reviews.

[22]  L. Kheirandish-Gozal,et al.  Cell-Selective Altered Cargo Properties of Extracellular Vesicles Following In Vitro Exposures to Intermittent Hypoxia , 2021, International journal of molecular sciences.

[23]  Lingyun Sun,et al.  Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy , 2021, Redox biology.

[24]  Bo Yang,et al.  EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury , 2021, Mediators of inflammation.

[25]  Q. Dong,et al.  Microglial Exosomes in Neurodegenerative Disease , 2021, Frontiers in Molecular Neuroscience.

[26]  T. Lan,et al.  Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression , 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

[27]  Bin Zhang,et al.  Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures , 2021, Biological Psychiatry.

[28]  Shanqun Li,et al.  NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea , 2021, Frontiers in Immunology.

[29]  Shi Qi Li,et al.  Chronic Intermittent Hypoxia-Induced Mitochondrial Dysfunction Mediates Endothelial Injury via the TXNIP/NLRP3/IL-1β Signaling Pathway. , 2021, Free radical biology & medicine.

[30]  Z. Lv,et al.  MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis , 2021, Frontiers in Cell and Developmental Biology.

[31]  R. Farré,et al.  Circulating exosomes and gut microbiome induced insulin resistance in mice exposed to intermittent hypoxia: Effects of physical activity. , 2021, EBioMedicine.

[32]  Kai Liu,et al.  Mesenchymal stem cell-derived exosome miR-542-3p suppresses inflammation and prevents cerebral infarction , 2021, Stem Cell Research & Therapy.

[33]  P. Edison,et al.  Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? , 2020, Nature Reviews Neurology.

[34]  L. Liang,et al.  Exosomes derived from miR-301a-3p-overexpressing adipose-derived mesenchymal stem cells reverse hypoxia-induced erectile dysfunction in rat models , 2020, Stem cell research & therapy.

[35]  Ya-Shuo Feng,et al.  The involvement of NLRP3 inflammasome in the treatment of Alzheimer’s disease , 2020, Ageing Research Reviews.

[36]  P. Lei,et al.  Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease , 2020, Alzheimer's Research & Therapy.

[37]  Kehkashan Parveen,et al.  The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury , 2020, Neural regeneration research.

[38]  Dandan Zong,et al.  The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome , 2020, Journal of Neuroinflammation.

[39]  R. Reynolds,et al.  Absence of miRNA-146a Differentially Alters Microglia Function and Proteome , 2020, Frontiers in Immunology.

[40]  Alfredo J Garcia,et al.  A HIF1a-Dependent Pro-Oxidant State Disrupts Synaptic Plasticity and Impairs Spatial Memory in Response to Intermittent Hypoxia , 2020, eNeuro.

[41]  Q. Dong,et al.  Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease. , 2020, Brain : a journal of neurology.

[42]  Yoshihisa Suzuki,et al.  Transplantation of M2-Deviated Microglia Promotes Recovery of Motor Function after Spinal Cord Injury in Mice. , 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

[43]  M. D. de Leon,et al.  Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research. , 2019, Sleep medicine reviews.

[44]  P. Sautière,et al.  Isolation of microglia-derived extracellular vesicles: towards miRNA signatures and neuroprotection , 2019, Journal of Nanobiotechnology.

[45]  Jian-ning Zhang,et al.  Increased Microglial Exosomal miR-124-3p Alleviates Neurodegeneration and Improves Cognitive Outcome after rmTBI , 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

[46]  L. Buée,et al.  NLRP3 inflammasome activation drives tau pathology , 2019, Nature.

[47]  Bin Zhao,et al.  Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model , 2019, Molecular therapy. Nucleic acids.

[48]  Changhong Li,et al.  Therapeutic effects of CPAP on cognitive impairments associated with OSA , 2019, Journal of Neurology.

[49]  Zongze Zhang,et al.  MicroRNA-146a protects against cognitive decline induced by surgical trauma by suppressing hippocampal neuroinflammation in mice , 2019, Brain, Behavior, and Immunity.

[50]  P. Vandenabeele,et al.  The molecular machinery of regulated cell death , 2019, Cell Research.

[51]  J. Filosa,et al.  NLRP3 inflammasome inhibition with MCC950 improves diabetes‐mediated cognitive impairment and vasoneuronal remodeling after ischemia , 2019, Pharmacological research.

[52]  D. Holtzman,et al.  The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans , 2019, Science.

[53]  Wenxi Tang,et al.  The Potential Role of the NLRP3 Inflammasome Activation as a Link Between Mitochondria ROS Generation and Neuroinflammation in Postoperative Cognitive Dysfunction , 2019, Front. Cell. Neurosci..

[54]  Xuan Sun,et al.  Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization , 2019, Cardiovascular research.

[55]  I. Dewachter,et al.  Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo , 2019, Acta Neuropathologica.

[56]  J. Ramirez,et al.  Intermittent Hypoxia Disrupts Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus , 2018, The Journal of Neuroscience.

[57]  Julio Fernandez-Mendoza,et al.  Obstructive sleep apnea and the metabolic syndrome: The road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment. , 2018, Sleep medicine reviews.

[58]  R. D'Hooge,et al.  Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology , 2018, Molecular Neurodegeneration.

[59]  S. Hickman,et al.  Microglia in neurodegeneration , 2018, Nature Neuroscience.

[60]  M. Pitts.  Barnes Maze Procedure for Spatial Learning and Memory in Mice. , 2018, Bio-protocol.

[61]  Graça Raposo,et al.  Shedding light on the cell biology of extracellular vesicles , 2018, Nature Reviews Molecular Cell Biology.

[62]  D. Cojoc,et al.  Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations , 2018, Acta Neuropathologica.

[63]  Y. Kong,et al.  Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage , 2018, Stroke.

[64]  Jinwen Yu,et al.  Increased miR‐124‐3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[65]  R. Bucks,et al.  INVITED REVIEW SERIES: RESPIRATORY SLEEP DISORDERS , 2017 .

[66]  Shuling Song,et al.  Effect of different levels of intermittent hypoxia on autophagy of hippocampal neurons , 2017, Sleep and Breathing.

[67]  Haitao Guo,et al.  NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes , 2017, The Journal of experimental medicine.

[68]  Jingyuan Chen,et al.  Cold Inducible RNA Binding Protein Is Involved in Chronic Hypoxia Induced Neuron Apoptosis by Down-Regulating HIF-1α Expression and Regulated By microRNA-23a , 2017, International journal of biological sciences.

[69]  M. Lynch,et al.  Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice , 2017, Brain, Behavior, and Immunity.

[70]  E. Mandelkow,et al.  Additional file 5: Figure S5. of The release and trans-synaptic transmission of Tau via exosomes , 2017 .

[71]  Jennifer Luebke,et al.  Depletion of microglia and inhibition of exosome synthesis halt tau propagation , 2015, Nature Neuroscience.

[72]  P. Bhargava,et al.  Animal models of sleep disorders. , 2013, Comparative medicine.

[73]  M. Heneka,et al.  NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice , 2012, Nature.

[74]  Y. Igarashi,et al.  Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia , 2012, The Journal of Biological Chemistry.

[75]  K. Roth,et al.  Cell Death and Neurodegeneration , 2011 .

[76]  N. Prabhakar,et al.  Hypoxia-inducible factors and obstructive sleep apnea , 2020 .

[77]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..