Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.
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B H Arison | R G Smith | D. Underwood | R. Freidinger | A. Patchett | J. Schaeffer | K. Chapman | K. Chapman | R. Mosley | B. Arison | A A Patchett | R M Freidinger | Scott C. Berk | J M Schaeffer | R. Smith | F. Foor | L Yang | S C Berk | S P Rohrer | R T Mosley | L Guo | D J Underwood | E T Birzin | E C Hayes | S W Mitra | R M Parmar | K Cheng | T J Wu | B S Butler | F Foor | A Pasternak | Y Pan | M Silva | K Chapman | A. Pasternak | S. Rohrer | E. Birzin | K. Cheng | M. Silva | T. Wu | S. Mitra | E. Hayes | B. Butler | L. Guo | R. M. Parmar | Tsuei-ju Wu | L. Yang | S. Berk | Yanping Pan | Y. Pan | T. Wu | James M. Schaeffer | Roy G. Smith | Kang Cheng | Dennis J. Underwood | Lihu Yang | Ralph T. Mosley | Liangqin Guo | Byron H. Arison | Edward C. Hayes | Bridgette S. Butler | Forrest Foor | Alexander Pasternak | Maria A. de Souza Silva
[1] L. Mahan,et al. Characterization of cloned somatostatin receptors SSTR4 and SSTR5. , 1993, Molecular pharmacology.
[2] C. Bruns,et al. Design, synthesis, and binding affinity of a nonpeptide mimic of somatostatin , 1992 .
[3] J. Vida,et al. Conformationally directed drug design : peptides and nucleic acids as templates or targets : based on a symposium sponsored by the Division of Medicinal Chemistry at the 186th Meeting of the American Chemical Society, Washington, D.C., August 28-September 2, 1983 , 1984 .
[4] A. Patchett,et al. Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. , 1998, Journal of medicinal chemistry.
[5] F. Raulf,et al. Somatostatin analogs for diagnosis and treatment of cancer. , 1993, Pharmacology & therapeutics.
[6] S. Reichlin. Somatostatin. , 1983, The New England journal of medicine.
[7] S. Reichlin. Somatostatin (First of two parts) , 1983 .
[8] Y. Patel. Molecular pharmacology of somatostatin receptor subtypes , 1997, Journal of endocrinological investigation.
[9] L. Hood,et al. Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus. , 1980, Proceedings of the National Academy of Sciences of the United States of America.
[10] É. Mezey,et al. Cell Specific Expression of the SST2A and SST5 Somatostatin Receptors in the Rat Anterior Pituitary. , 1998, Endocrinology.
[11] S. Melmed,et al. Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation. , 1997, The Journal of clinical investigation.
[12] M. Berelowitz,et al. Molecular cloning and functional expression of a brain-specific somatostatin receptor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[13] T. Reisine,et al. Synthesis and conformations of somatostatin-related cyclic hexapeptides incorporating specific .alpha.- and .beta.-methylated residues , 1993 .
[14] A. Motta,et al. Cyclic hexapeptides related to somatostatin. Conformational analysis employing 1H-NMR and molecular dynamics. , 2009, International journal of peptide and protein research.
[15] L. Mahan,et al. Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin: 28. , 1992, Molecular pharmacology.
[16] S. Lamberts. The role of somatostatin in the regulation of anterior pituitary hormone secretion and the use of its analogs in the treatment of human pituitary tumors. , 1988, Endocrine reviews.
[17] S. Melmed,et al. Structure and function of somatostatin receptors in growth hormone control. , 1997, The Journal of endocrinology.
[18] Joseph M. Salvino,et al. De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing beta-D-glucose as a novel scaffolding , 1993 .
[19] S. Mignani,et al. Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/sandostatin® , 1996 .
[20] Robert P. Sheridan,et al. Flexibases: A way to enhance the use of molecular docking methods , 1994, J. Comput. Aided Mol. Des..
[21] M. Greenwood,et al. All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase. , 1994, Biochemical and biophysical research communications.
[22] D. Johnston,et al. Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[23] Lois E. H. Smith,et al. Essential role of growth hormone in ischemia-induced retinal neovascularization. , 1997, Science.
[24] Molecular biology of somatostatin receptors. , 1995, Endocrine reviews.
[25] D. Veber,et al. Inferences about the conformation of somatostatin at a biologic receptor based on NMR studies , 1978 .
[26] V. Mutt,et al. N‐terminally extended somatostatin: The primary structure of somatostatin‐28 , 1980, FEBS letters.
[27] L. Kvols,et al. Advances in the use of somatostatins in the management of endocrine tumors. , 1996, Current opinion in oncology.
[28] J. Epelbaum. Somatostatin in the central nervous system: Physiology and pathological modifications , 1986, Progress in Neurobiology.
[29] D. Coy,et al. The New Pharmacology of Somatostatin and its Multiple Receptors , 1993, The Journal of pediatric endocrinology.
[30] C. Papageorgiou,et al. A non-peptide ligand for the somatostatin receptor having a benzodiazepinone structure , 1996 .
[31] M. Karplus,et al. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations , 1983 .
[32] Y. Cheng,et al. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. , 1973, Biochemical pharmacology.
[33] E. Krenning,et al. The role of somatostatin and its analogs in the diagnosis and treatment of tumors. , 1991, Endocrine reviews.
[34] F. D. Leeuw,et al. The relationship between proton-proton NMR coupling constants and substituent electronegativities—I : An empirical generalization of the karplus equation , 1980 .
[35] L. Pradayrol,et al. Effects of somatostatin-14 and somatostatin-28 on bombesin-stimulated release of gastrin, insulin, and glucagon in the dog. , 1981, Endocrinology.
[36] B. E. Evans,et al. Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. , 1988, Journal of Medicinal Chemistry.
[37] T. Reisine,et al. Main chain and side chain chiral methylated somatostatin analogs : syntheses and conformational analyses , 1992 .
[38] G. Krejs. Physiological role of somatostatin in the digestive tract: gastric acid secretion, intestinal absorption, and motility. , 1986, Scandinavian journal of gastroenterology. Supplement.
[39] S. Seino,et al. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[40] É. Mezey,et al. Immunohistochemical Localization of Somatostatin Receptor SST2A in the Rat Pancreas. , 1997, Endocrinology.
[41] C. Saper,et al. Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase. , 1992, The Journal of biological chemistry.
[42] L. Mahan,et al. Method for identifying ligands that bind to cloned Gs- or Gi-coupled receptors , 1991, Molecular and Cellular Neuroscience.
[43] D. Coy,et al. Three-dimensional quantitative structure-activity relationships of somatostatin analogues. 1. Comparative molecular field analysis of growth hormone release-inhibiting potencies. , 1995, Journal of medicinal chemistry.
[44] T. Halgren. Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94 , 1996, J. Comput. Chem..
[45] D. Coy,et al. Specific inhibition of rat pancreatic insulin or glucagon release by receptor-selective somatostatin analogs. , 1994, Biochemical and biophysical research communications.
[46] N. Ling,et al. Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion , 1981, Nature.