Reciprocal zones of excitation and inhibition in the neostriatum

Single‐unit activity was recorded in the rat neostriatum at different distances from the point of an infusion of either glutamate or serotonin. In each case, firing rate at the distant site (0.8–1.5 mm) was the mirror image of that at the near site (0.1–0.3 mm). These reciprocal changes were blocked by a subsequent injection of haloperidol, a dopamine antagonist. It appears that a lateral inhibitory network, intrinsic to the neostriatum and possibly modulated by dopamine, plays an important role in the operation of the neostriatum.

[1]  R. Hassler.  Striatal control of locomotion, intentional actions and of integrating and perceptive activity , 1978, Journal of the Neurological Sciences.

[2]  T. Pasik,et al.  The Internal Organization of the Neostriatum in Mammals , 1979 .

[3]  Charles J. Wilson,et al.  Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: A study employing intracellular injection of horseradish peroxidase , 1980 .

[4]  A. Dray.  The physiology and pharmacology of mammalian basal ganglia , 1980, Progress in Neurobiology.

[5]  Melburn R. Park,et al.  Recurrent inhibition in the rat neostriatum , 1980, Brain Research.

[6]  P. Somogyi,et al.  Monosynaptic cortical input and local axon collaterals of identified striatonigral neurons. A light and electron microscopic study using the golgi‐peroxidase transport‐degeneration procedure , 1981, The Journal of comparative neurology.

[7]  Charles J. Wilson,et al.  Spontaneous firing patterns of identified spiny neurons in the rat neostriatum , 1981, Brain Research.

[8]  S. T. Kitai,et al.  Single neostriatal efferent axons in the globus pallidus: a light and electron microscopic study. , 1981, Science.

[9]  Y. Katayama,et al.  Electrophysiological evidence favoring intracaudate axon collaterals of GABAergic caudate output neurons in the cat , 1981, Brain Research.

[10]  P. Groves.  A theory of the functional organization of the neostriatum and the neostriatal control of voluntary movement , 1983, Brain Research Reviews.

[11]  G. Rebec,et al.  Reciprocal changes in the firing rate of neostriatal and dorsal raphe neurons following local infusions or systemic injections of D- amphetamine: evidence for neostriatal heterogeneity , 1983, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[12]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[13]  E. T. Rolls,et al.  Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness , 1984, Neuroscience.

[14]  T. F. Freund,et al.  Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines , 1984, Neuroscience.

[15]  C. Gerfen.  The neostriatal mosaic. I. compartmental organization of projections from the striatum to the substantia nigra in the rat , 1985, The Journal of comparative neurology.

[16]  Theodore W. Berger,et al.  Interactions between dopamine and amino acid-induced excitation and inhibition in the striatum , 1986, Brain Research.

[17]  G. Rebec.  Electrophysiological Pharmacology of Amphetamine1 , 1987 .