Modulation of antisaccades by transcranial magnetic stimulation of the human frontal eye field.

It has been suggested that the frontal eye field (FEF), which is involved with the inhibition and generation of saccades, is engaged to a different degree in pro- and antisaccades. Pro- and antisaccades are often assessed in separate experimental blocks. In such cases, saccade inhibition is required for antisaccades but not for prosaccades. To more directly assess the role of the FEF in saccade inhibition and generation, a new paradigm was used in which inhibition was necessary on pro- and antisaccade trials. Participants looked in the direction indicated by a target ('<' or '>') that appeared in the left or right visual field. When the pointing direction and the location were congruent, prosaccades were executed; otherwise antisaccades were required. Saccadic latencies were measured in blocks without and with single pulse transcranial magnetic stimulation (TMS) to the right FEF or a right posterior control site. Results showed that antisaccades generated into the hemifield ipsilateral to the TMS were significantly delayed after TMS over the FEF, but not the posterior control site. This result is interpreted in terms of a modulation of saccade inhibition to the contralateral visual field due to disruption of processing in the FEF.

[1]  Ravi S. Menon,et al.  A comparison of frontoparietal fMRI activation during anti-saccades and anti-pointing. , 2000, Journal of neurophysiology.

[2]  D. Levy,et al.  Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomography. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[3]  T. Paus,et al.  Transcranial Magnetic Stimulation of the Human Frontal Eye Field: Effects on Visual Perception and Attention , 2002, Journal of Cognitive Neuroscience.

[4]  M. Posner The Cognitive Neuroscience of Attention , 2020 .

[5]  Liana Machado,et al.  Control of fixation and saccades during an anti-saccade task: an investigation in humans with chronic lesions of oculomotor cortex , 2004, Experimental Brain Research.

[6]  R. Rafal,et al.  Localization of the human frontal eye fields and motor hand area with transcranial magnetic stimulation and magnetic resonance imaging , 1998, Neuropsychologia.

[7]  Ravi S. Menon,et al.  Preparatory set associated with pro-saccades and anti-saccades in humans investigated with event-related FMRI. , 2003, Journal of neurophysiology.

[8]  L. Sawaki,et al.  Specific and non-specific effects of transcranial magnetic stimulation on simple and go/no-go reaction time , 1999, Experimental Brain Research.

[9]  M. Saslow Effects of components of displacement-step stimuli upon latency for saccadic eye movement. , 1967, Journal of the Optical Society of America.

[10]  Tony Ro,et al.  Inhibition of return and the human frontal eye fields , 2003, Experimental Brain Research.

[11]  Avishai Henik,et al.  Endogenously Generated and Visually Guided Saccades after Lesions of the Human Frontal Eye Fields , 1994, Journal of Cognitive Neuroscience.

[12]  Takashi R Sato,et al.  Effects of Stimulus-Response Compatibility on Neural Selection in Frontal Eye Field , 2003, Neuron.

[13]  S. Everling,et al.  The antisaccade: a review of basic research and clinical studies , 1998, Neuropsychologia.

[14]  Y Agid,et al.  Cortical control of reflexive visually-guided saccades. , 1991, Brain : a journal of neurology.

[15]  O Hikosaka,et al.  Visualization of the information flow through human oculomotor cortical regions by transcranial magnetic stimulation. , 1998, Journal of neurophysiology.

[16]  R. Douglas,et al.  Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades , 2004, Experimental Brain Research.

[17]  P. C. Murphy,et al.  Cerebral Cortex , 2017, Cerebral Cortex.

[18]  D P Munoz,et al.  Neuronal Correlates for Preparatory Set Associated with Pro-Saccades and Anti-Saccades in the Primate Frontal Eye Field , 2000, The Journal of Neuroscience.

[19]  D. Munoz,et al.  Reflex suppression in the anti-saccade task is dependent on prestimulus neural processes. , 1998, Journal of neurophysiology.

[20]  T. Moore,et al.  Microstimulation of the frontal eye field and its effects on covert spatial attention. , 2004, Journal of neurophysiology.

[21]  B. Gaymard,et al.  Eye movement disorders after frontal eye field lesions in humans , 2004, Experimental Brain Research.

[22]  J. Schall Visuomotor Areas of the Frontal Lobe , 1997 .

[23]  C. Pierrot-Deseilligny,et al.  Eye movement control by the cerebral cortex , 2004, Current opinion in neurology.

[24]  M. Corbetta,et al.  A Common Network of Functional Areas for Attention and Eye Movements , 1998, Neuron.

[25]  Tony Ro,et al.  Locating the Human Frontal Eye Fields With Transcranial Magnetic Stimulation , 2002, Journal of clinical and experimental neuropsychology.

[26]  Alan Kingstone,et al.  Why are antisaccades slower than prosaccades? A novel finding using a new paradigm , 2003, Neuroreport.

[27]  F. J. Friedrich,et al.  Spatial attention deficits in humans: a comparison of superior parietal and temporal-parietal junction lesions. , 1998, Neuropsychology.

[28]  Joshua W. Brown,et al.  Monitoring and Control of Action by the Frontal Lobes , 2002, Neuron.

[29]  R. Klein,et al.  A review of the evidence for a disengage deficit following parietal lobe damage , 2001, Neuroscience & Biobehavioral Reviews.

[30]  C. Bruce,et al.  Suppression of task-related saccades by electrical stimulation in the primate's frontal eye field. , 1997, Journal of neurophysiology.

[31]  Amelia R Hunt,et al.  Integration of competing saccade programs. , 2004, Brain research. Cognitive brain research.

[32]  Lotfi B Merabet,et al.  Transcranial Magnetic Stimulation as an Investigative Tool in the Study of Visual Function , 2003, Optometry and vision science : official publication of the American Academy of Optometry.

[33]  C. W. Hess,et al.  Transcranial stimulation of the human frontal eye field by magnetic pulses , 2004, Experimental Brain Research.

[34]  B. Gaymard,et al.  The frontal eye field is involved in spatial short-term memory but not in reflexive saccade inhibition , 1999, Experimental Brain Research.

[35]  C. Pierrot-Deseilligny,et al.  Cortical control of saccades in man. , 1991, Acta neurologica Belgica.

[36]  R. Rafal,et al.  Looking forward to looking: Saccade preparation and control of the visual grasp reflex , 2000 .

[37]  M. Schlag-Rey,et al.  Antisaccade performance predicted by neuronal activity in the supplementary eye field , 1997, Nature.

[38]  F. J. Friedrich,et al.  Effects of parietal injury on covert orienting of attention , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[39]  R. Rafal,et al.  Transcranial Magnetic Stimulation of the Prefrontal Cortex Delays Contralateral Endogenous Saccades , 1997, Journal of Cognitive Neuroscience.

[40]  S. Tieman,et al.  Cerebral dominance in monkeys? , 1974, Neuropsychologia.