On the genealogy of tissue engineering and regenerative medicine.

In this article, we identify and discuss a timeline of historical events and scientific breakthroughs that shaped the principles of tissue engineering and regenerative medicine (TERM). We explore the origins of TERM concepts in myths, their application in the ancient era, their resurgence during Enlightenment, and, finally, their systematic codification into an emerging scientific and technological framework in recent past. The development of computational/mathematical approaches in TERM is also briefly discussed.

[1]  Anthony Atala,et al.  Engineering Complex Tissues , 2012, Science Translational Medicine.

[2]  近久 芳昭,et al.  N.Rashevsky: "Mathematical Biophysics, Physico-Mathematical Foundations of Biology", Dover Publications, New York, 1960. VoI. I, 488頁, Vol. II, 462頁, 14×20.5cm, 各巻$2.50. , 1961 .

[3]  François Berthiaume,et al.  Tissue Engineering and Regenerative Medicine : History , Progress , and Challenges , 2013 .

[4]  N. L. Hayes,et al.  New neurons: extraordinary evidence or extraordinary conclusion? , 2000, Science.

[5]  A. Ehrenfried Reverdin and Other Methods of Skin-Grafting: Historical , 1909 .

[6]  B. Spinoza,et al.  The chief works of Benedict de Spinoza , 1883 .

[7]  Ali Khademhosseini,et al.  Microengineered hydrogels for tissue engineering. , 2007, Biomaterials.

[8]  J. Vacanti,et al.  Beyond transplantation. Third annual Samuel Jason Mixter lecture. , 1988, Archives of surgery.

[9]  Buddy D. Ratner,et al.  A History of Biomaterials , 2020, Biomaterials Science.

[10]  L. Chick Brief history and biology of skin grafting. , 1988, Annals of plastic surgery.

[11]  Anthony Atala,et al.  Tissue-engineered autologous vaginal organs in patients: a pilot cohort study , 2014, The Lancet.

[12]  L. Girard,et al.  False teeth of the Roman world , 1998, Nature.

[13]  A. Jaretzki,et al.  The use of tubes constructed from vinyon "N" cloth in bridging arterial defects. , 1952, Annals of surgery.

[14]  J. Witkowski Alexis Carrel and the mysticism of tissue culture. , 1979, Medical History.

[15]  Christian Heinrich Pander Dissertatio inauguralis sistens historiam metamorphoseos, quam ovum incubatum prioribus quinque diebus subit , 1817 .

[16]  Luca Cucullo,et al.  Drug delivery and in vitro models of the blood-brain barrier. , 2005, Current opinion in drug discovery & development.

[17]  J. Folkman,et al.  Role of cell shape in growth control , 1978, Nature.

[18]  H. B. Fell,et al.  Tissue culture and its contribution to biology and medicine. , 1972, The Journal of experimental biology.

[19]  Frédéric Marin,et al.  A marriage of bone and nacre , 1998, Nature.

[20]  Himanshu Kaul A multi-paradigm modelling framework for simulating biocomplexity , 2013 .

[21]  Robert Langer,et al.  The History of Tissue Engineering Using Synthetic Biodegradable Polymer Scaffolds and Cells , 1997 .

[22]  Ivan Martin,et al.  Bioreactor-based roadmap for the translation of tissue engineering strategies into clinical products. , 2009, Trends in biotechnology.

[23]  J. Folkman,et al.  SELF-REGULATION OF GROWTH IN THREE DIMENSIONS , 1973, The Journal of experimental medicine.

[24]  Himanshu Kaul,et al.  Investigating biocomplexity through the agent-based paradigm , 2013, Briefings Bioinform..

[25]  Arthur A. Zierold,et al.  Reaction of Bone to Various Metals , 1924 .

[26]  Stuart K Williams,et al.  Assessment of the intimal response to a protein-modified stent in a tissue-engineered blood vessel mimic. , 2009, Tissue engineering. Part A.

[27]  C. Mason,et al.  The need for a regen industry voice. , 2008, Regenerative medicine.

[28]  C. Picioreanu,et al.  Variable cell morphology approach for individual-based modeling of microbial communities. , 2014, Biophysical journal.

[29]  Sorin Istrail,et al.  Alan Turing and John von Neumann - Their Brains and Their Computers , 2012, Int. Conf. on Membrane Computing.

[30]  Kristen O'Halloran Cardinal,et al.  Thinking inside the box: keeping tissue-engineered constructs in vitro for use as preclinical models. , 2013, Tissue engineering. Part B, Reviews.

[31]  J. Pudney,et al.  Development of an in vitro alternative assay method for vaginal irritation. , 2011, Toxicology.

[32]  David J. Williams,et al.  Precision manufacturing for clinical-quality regenerative medicines , 2012, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[33]  Charles A Vacanti,et al.  The history of tissue engineering , 2006, Journal of cellular and molecular medicine.

[34]  Markus Gugatschka,et al.  Regenerative medicine of the larynx. Where are we today? A review. , 2012, Journal of voice : official journal of the Voice Foundation.

[35]  Michael T Longaker,et al.  Progress and potential for regenerative medicine. , 2007, Annual review of medicine.

[36]  Stéphane Schmitt From eggs to fossils: epigenesis and transformation of species in Pander's biology. , 2005, The International journal of developmental biology.

[37]  Thomas L. Hankins,et al.  Science and the Enlightenment , 1970 .

[38]  A. Bhargave,et al.  Organogenesis by Desired Metaplasia of Autogenous Stem Cells , 1998, Annals of the New York Academy of Sciences.

[39]  Paul Kemp,et al.  History of regenerative medicine: looking backwards to move forwards. , 2006, Regenerative medicine.

[40]  L. Griffith,et al.  Tissue Engineering--Current Challenges and Expanding Opportunities , 2002, Science.

[41]  H. Wulff The concept of disease: from Newton back to Aristotle , 1999, The Lancet.

[42]  Gordon Keller,et al.  Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development , 2008, Cell.

[43]  Yimin Zhao,et al.  Clinical transplantation of a tissue-engineered airway , 2009, The Lancet.

[44]  Stephen F Badylak,et al.  RETRACTED: Engineered whole organs and complex tissues , 2012, The Lancet.

[45]  Winfried Neuhaus,et al.  A novel flow based hollow-fiber blood-brain barrier in vitro model with immortalised cell line PBMEC/C1-2. , 2006, Journal of biotechnology.

[46]  H. Levert Experiments on the use of Metallic Ligatures, as applied to Arteries , 1829 .

[47]  José Cotovio,et al.  The EpiSkin phototoxicity assay (EPA): development of an in vitro tiered strategy using 17 reference chemicals to predict phototoxic potency. , 2007, Toxicology in vitro : an international journal published in association with BIBRA.

[48]  I. Papantoniou,et al.  Reconstruction of an in vitro cornea and its use for drug permeation studies from different formulations containing pilocarpine hydrochloride. , 2001, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[49]  C. Mason,et al.  A brief definition of regenerative medicine. , 2008, Regenerative medicine.

[50]  James J. Yoo,et al.  Tissue-engineered autologous urethras for patients who need reconstruction: an observational study , 2011, The Lancet.

[51]  D. Janigro,et al.  Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models. , 1998, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[52]  Y. Imai,et al.  Transplantation of a tissue-engineered pulmonary artery. , 2001, The New England journal of medicine.

[53]  R. Virchow,et al.  Cellular Pathology, as Based upon Physiological and Pathological Histology , 1860, Nutrition reviews.

[54]  Johannes S. Vrouwenvelder,et al.  Three-dimensional modeling of biofouling and fluid dynamics in feed spacer channels of membrane devices , 2009 .

[55]  Elaine McClarence Close To The Edge: Branemark And The Development Of Osseointegration , 2003 .

[56]  Ann B. Parson,et al.  Stem Cell Biotech: Seeking a Piece of the Action , 2008, Cell.

[57]  C. Mason ISSCR 2009 Industry Panel Session: promoting translation and commercialization. , 2009, Cell stem cell.

[58]  A. M. Turing,et al.  The chemical basis of morphogenesis , 1952, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.

[59]  C. Lindbergh,et al.  THE CULTURE OF WHOLE ORGANS. , 2022, Science.

[60]  Stuart K Williams,et al.  Tissue-engineered vascular grafts as in vitro blood vessel mimics for the evaluation of endothelialization of intravascular devices. , 2006, Tissue engineering.

[61]  D. Birchall,et al.  Computational Fluid Dynamics , 2020, Radial Flow Turbocompressors.

[62]  B. Thiers Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2008 .

[63]  H. Kim,et al.  Tissue engineering in dentistry. , 2014, Journal of dentistry.

[64]  Min Jae Song,et al.  In Situ Spatiotemporal Mapping of Flow Fields around Seeded Stem Cells at the Subcellular Length Scale , 2010, PloS one.

[65]  Cato T Laurencin,et al.  Bone tissue engineering: recent advances and challenges. , 2012, Critical reviews in biomedical engineering.

[66]  G. D. de Freitas,et al.  Review of Preclinical and Clinical Studies of Bone Marrow-Derived Cell Therapies for Intracerebral Hemorrhage , 2016, Stem cells international.

[67]  M. J. Greenman,et al.  Observations of the living developing nerve fiber , 1907 .

[68]  Ulrike Szeimies,et al.  Ancient Egyptian prosthesis of the big toe , 2000, The Lancet.

[69]  R Cancedda,et al.  Repair of large bone defects with the use of autologous bone marrow stromal cells. , 2001, The New England journal of medicine.

[70]  J. Pudney,et al.  Organotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products. , 2006, Toxicology in vitro : an international journal published in association with BIBRA.

[71]  Cwj Cees Oomens,et al.  Compression Induced Cell Damage in Engineered Muscle Tissue: An In Vitro Model to Study Pressure Ulcer Aetiology , 2003, Annals of Biomedical Engineering.

[72]  J. Vacanti,et al.  Time-lapse photography: a novel tool to study normal morphogenesis and the diseased hepatobiliary system in children. , 1988, Journal of pediatric surgery.

[73]  John L. Semple,et al.  Review: In Vitro, in Vivo, in Silico: Computational Systems in Tissue Engineering and Regenerative Medicine , 2005 .

[74]  G. Vunjak‐Novakovic,et al.  Engineered microenvironments for controlled stem cell differentiation. , 2009, Tissue engineering. Part A.

[75]  David J. Williams,et al.  Cell Culture Automation and Quality Engineering: A Necessary Partnership to Develop Optimized Manufacturing Processes for Cell-Based Therapies , 2008 .

[76]  Zee Upton,et al.  Development of a three-dimensional human skin equivalent wound model for investigating novel wound healing therapies. , 2010, Tissue engineering. Part C, Methods.

[77]  Leaman,et al.  Dynamic modeling of the blood-brain barrier: a novel tool for studies of drug delivery to the brain. , 1999, Pharmaceutical science & technology today.

[78]  C. Evans Advances in regenerative orthopedics. , 2013, Mayo Clinic proceedings.

[79]  Charles J Lumsden,et al.  In vitro, in vivo, in silico: computational systems in tissue engineering and regenerative medicine. , 2005, Tissue engineering.

[80]  J. Schwartz,et al.  Theory of Self-Reproducing Automata , 1967 .

[81]  M. Schaller,et al.  Candida albicans-Secreted Aspartic Proteinases Modify the Epithelial Cytokine Response in an In Vitro Model of Vaginal Candidiasis , 2005, Infection and Immunity.

[82]  Judah Folkman,et al.  Angiogenesis in vitro , 1980, Nature.

[83]  G. Naughton,et al.  From Lab Bench to Market , 2002 .

[84]  Erika García-López,et al.  A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies. , 2013, Lab on a chip.

[85]  J. Kassis,et al.  3D in vitro tissue models and their potential for drug screening , 2013, Expert opinion on drug discovery.

[86]  M. Kaufman,et al.  Establishment in culture of pluripotential cells from mouse embryos , 1981, Nature.

[87]  Michele De Luca,et al.  Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium , 1997, The Lancet.

[88]  Ana Jaklenec,et al.  Great expectations: private sector activity in tissue engineering, regenerative medicine, and stem cell therapeutics. , 2008, Tissue engineering. Part A.

[89]  P. Froment,et al.  An engineered 3D blood-testis barrier model for the assessment of reproductive toxicity potential. , 2010, Biomaterials.

[90]  C. Mason,et al.  Lessons for the nascent regenerative medicine industry from the biotech sector. , 2007, Regenerative medicine.

[91]  F. Luyten,et al.  Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology , 2011, Journal of cellular and molecular medicine.

[92]  D. Feliciano,et al.  Alexis Carrel (1873-1944): Nobel Laureate, 1912. , 2005, Archives of surgery.

[93]  Abdallah S Daar,et al.  A proposed definition of regenerative medicine , 2007, Journal of tissue engineering and regenerative medicine.

[94]  W. T. Green Articular cartilage repair. Behavior of rabbit chondrocytes during tissue culture and subsequent allografting. , 1977, Clinical orthopaedics and related research.

[95]  Vladimir Mironov,et al.  Review: bioprinting: a beginning. , 2006, Tissue engineering.

[96]  Jeroen Rouwkema,et al.  In vitro platforms for tissue engineering: implications for basic research and clinical translation , 2011, Journal of tissue engineering and regenerative medicine.

[97]  U. Jonas,et al.  Tissue engineering from Adam to the zygote: historical reflections , 2000, World Journal of Urology.

[98]  C. Lindbergh AN APPARATUS FOR THE CULTURE OF WHOLE ORGANS , 1935, The Journal of experimental medicine.

[99]  H. Ridley,et al.  Intra-Ocular Acrylic Lenses * , 1952, The British journal of ophthalmology.

[100]  J. Thomson,et al.  Embryonic stem cell lines derived from human blastocysts. , 1998, Science.

[101]  Y. Hashimoto,et al.  Cartilage Repair With Autologous Bone Marrow Mesenchymal Stem Cell Transplantation , 2014, Cartilage.

[102]  J J Heijnen,et al.  Mathematical modeling of biofilm structure with a hybrid differential-discrete cellular automaton approach. , 1998, Biotechnology and bioengineering.

[103]  P. Macchiarini,et al.  Clinical transplantation of a tissue-engineered airway – Authors' reply , 2009, The Lancet.

[104]  A. Carrel,et al.  THE BEHAVIOR OF ABNORMAL HUMAN THYROID TISSUE CULTIVATED IN THE LINDBERGH APPARATUS , 1939, Journal of Experimental Medicine.

[105]  Robert Langer,et al.  Progress in the tissue engineering and stem cell industry "are we there yet?". , 2012, Tissue engineering. Part B, Reviews.

[106]  G. Jonkers Intra-Ocular Acrylic Lenses , 1953 .

[107]  R. Stewart,et al.  Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells , 2007, Science.

[108]  G. Naughton,et al.  From lab bench to market: critical issues in tissue engineering. , 2002, Annals of the New York Academy of Sciences.

[109]  Arun Gupta,et al.  A new technique of “Marlex®-peritoneal sandwich” in the repair of large incisional hernias , 1991, World journal of surgery.

[110]  M. Pope,et al.  Giovanni Alfonso Borelli--the father of biomechanics. , 2005, Spine.

[111]  Matthias Reuss,et al.  Modeling the dynamics of E. coli populations in the three-dimensional turbulent field of a stirred-tank bioreactor- : A structured-segregated approach , 2006 .

[112]  C. P. Swanson,et al.  Mathematical Biophysics. Physico-Mathematical Foundations of Biology.N. RashevskyRadiation Protection and Recovery.Alexander Hollaender , 1961 .

[113]  Alexis Carrel,et al.  ARTIFICIAL ACTIVATION OF THE GROWTH IN VITRO OF CONNECTIVE TISSUE , 1913, The Journal of experimental medicine.

[114]  M. Conconi,et al.  Clinical transplantation of a tissue-engineered airway (vol 372, pg 2023, 2008) , 2009 .

[115]  Lieven Thorrez,et al.  Drug‐screening platform based on the contractility of tissue‐engineered muscle , 2008, Muscle & nerve.

[116]  C. Cheng,et al.  Disruption of the blood-testis barrier integrity by bisphenol A in vitro: is this a suitable model for studying blood-testis barrier dynamics? , 2009, The international journal of biochemistry & cell biology.

[117]  Phil G Campbell,et al.  Tissue engineering with the aid of inkjet printers , 2007 .

[118]  R Langer,et al.  Selective cell transplantation using bioabsorbable artificial polymers as matrices. , 1988, Journal of pediatric surgery.

[119]  R. Tsai,et al.  Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. , 2000, The New England journal of medicine.

[120]  Robert Langer,et al.  Principles of tissue engineering , 2014 .

[121]  Sheldon Penman,et al.  Protein synthesis requires cell-surface contact while nuclear events respond to cell shape in anchorage-dependent fibroblasts , 1980, Cell.

[122]  R Roguet,et al.  The use of in vitro reconstituted human skin in dermotoxicity testing. , 1994, Toxicology in vitro : an international journal published in association with BIBRA.

[123]  Walter S. Zapotoczny The Impact of the Industrial Revolution on Warfare , 2007 .

[124]  A. Bobbio The first endosseous alloplastic implant in the history of man. , 1972, Bulletin of the history of dentistry.

[125]  G. Martin,et al.  Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[126]  J. M. Yoffey,et al.  REGENERATION OF BONE MARROW. A CLINICAL AND EXPERIMENTAL STUDY FOLLOWING REMOVAL OF BONE MARROW BY CURETTAGE. , 1962, Acta Anatomica.

[127]  R. Chamuleau Artificial Liver Support in the Third Millennium , 2003, Artificial cells, blood substitutes, and immobilization biotechnology.

[128]  R. G. Harrison The outgrowth of the nerve fiber as a mode of protoplasmic movement. , 1910, The Journal of experimental zoology.

[129]  J. Till,et al.  Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells , 1963, Nature.

[130]  H. Lenhoff,et al.  Hydra and the Birth of Experimental Biology, 1744: Abraham Trembley's Memoires Concerning the Polyps , 1986 .

[131]  M. Abercrombie,et al.  Observations on the social behaviour of cells in tissue culture. I. Speed of movement of chick heart fibroblasts in relation to their mutual contacts. , 1953, Experimental cell research.

[132]  David J. Williams,et al.  Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine. , 2011, British medical bulletin.

[133]  F. Yuan,et al.  A review of three-dimensional in vitro tissue models for drug discovery and transport studies. , 2011, Journal of pharmaceutical sciences.

[134]  Shayn M. Peirce,et al.  Multi-cell Agent-based Simulation of the Microvasculature to Study the Dynamics of Circulating Inflammatory Cell Trafficking , 2007, Annals of Biomedical Engineering.

[135]  A. Blakemore,et al.  THE USE OF TUBES CONSTRUCTED FROM VINYON “N” CLOTH IN BRIDGING ARTERIAL DEFECTS—EXPERIMENTAL AND CLINICAL , 1954, Annals of surgery.

[136]  David J. Williams,et al.  Automated, scalable culture of human embryonic stem cells in feeder‐free conditions , 2009, Biotechnology and bioengineering.

[137]  U. Mueller,et al.  Monoculture of Leafcutter Ant Gardens , 2010, PloS one.

[138]  J. Folkman,et al.  Angiogenesis by capillary endothelial cells in culture. , 1980, Transactions of the ophthalmological societies of the United Kingdom.

[139]  P. Russell Selective Transplantation: An Emerging Concept , 1985, Annals of surgery.

[140]  P. Branemark Osseointegration and its experimental background. , 1983, The Journal of prosthetic dentistry.

[141]  D. Janigro,et al.  Dynamic in vitro modeling of the blood–brain barrier: a novel tool for studies of drug delivery to the brain , 1999 .

[142]  M. Abercrombie,et al.  Observations on the social behaviour of cells in tissue culture. II. Monolayering of fibroblasts. , 1954, Experimental cell research.

[143]  H. Morowitz The Emergence of Everything: How the World Became Complex , 2002 .

[144]  Anthony Atala,et al.  Regenerative medicine and organ transplantation: past, present, and future. , 2011, Transplantation.

[145]  James J. Yoo,et al.  Tissue-engineered autologous bladders for patients needing cystoplasty , 2006, The Lancet.

[146]  Patrick L. Griffin,et al.  Functional information and the emergence of biocomplexity , 2007, Proceedings of the National Academy of Sciences.

[147]  L. Germain,et al.  Tissue-engineered human vascular media produced in vitro by the self-assembly approach present functional properties similar to those of their native blood vessels. , 2006, Tissue engineering.

[148]  R Roguet,et al.  Episkin: An in vitro model for the evaluation of phototoxicity and sunscreen photoprotective properties. , 1994, Toxicology in vitro : an international journal published in association with BIBRA.

[149]  M. Ramalho-Santos,et al.  On the origin of the term "stem cell". , 2007, Cell stem cell.

[150]  N. Brown,et al.  Commercial development of stem cell technology: lessons from the past, strategies for the future. , 2006, Regenerative medicine.

[151]  Chris Mason,et al.  Regenerative medicine cell therapies: numbers of units manufactured and patients treated between 1988 and 2010. , 2010, Regenerative medicine.

[152]  D. Wendt,et al.  The role of bioreactors in tissue engineering. , 2004, Trends in biotechnology.

[153]  J. Altman,et al.  Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats , 1965, The Journal of comparative neurology.

[154]  Yiannis Ventikos,et al.  A Multi-Paradigm Modeling Framework to Simulate Dynamic Reciprocity in a Bioreactor , 2013, PloS one.

[155]  K. Omori,et al.  Clinical Application of in Situ Tissue Engineering Using a Scaffolding Technique for Reconstruction of the Larynx and Trachea , 2008, The Annals of otology, rhinology, and laryngology.