Huanglian Jiedu decoction inhibits vascular smooth muscle cell-derived foam cell formation by activating autophagy via suppressing P2RY12.

[1]  Yangxu Zhou,et al.  The efficacy of modified HuangLian JieDu decoction for early enteral nutrition in patients with sepsis: A randomized controlled study , 2022, Medicine.

[2]  M. Acosta-Martínez,et al.  The PI3K/Akt Pathway in Meta-Inflammation , 2022, International journal of molecular sciences.

[3]  Cathy H. Wu,et al.  UniProt: the Universal Protein Knowledgebase in 2023 , 2022, Nucleic Acids Res..

[4]  Honglin Dong,et al.  How vascular smooth muscle cell phenotype switching contributes to vascular disease , 2022, Cell Communication and Signaling.

[5]  K. Rayner,et al.  Regulated Necrosis in Atherosclerosis. , 2022, Arteriosclerosis, Thrombosis and Vascular Biology.

[6]  D. Baptista,et al.  The E3 Ubiquitin Ligase Peli1 Deficiency Promotes Atherosclerosis Progression , 2022, Cells.

[7]  Yinghui Lu,et al.  Systems pharmacology, proteomics and in vivo studies identification of mechanisms of cerebral ischemia injury amelioration by Huanglian Jiedu Decoction. , 2022, Journal of ethnopharmacology.

[8]  Haotian Li,et al.  Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis , 2022, Comput. Biol. Medicine.

[9]  Chong Lu,et al.  Endoplasmic reticulum stress promotes breast cancer cells to release exosomes circ_0001142 and induces M2 polarization of macrophages to regulate tumor progression. , 2022, Pharmacological research.

[10]  Saizhen Chen,et al.  The Anti-Inflammatory and Anti-Pruritus Mechanisms of Huanglian Jiedu Decoction in the Treatment of Atopic Dermatitis , 2021, Frontiers in Pharmacology.

[11]  Mingxian Chen,et al.  Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux , 2021, Journal of advanced research.

[12]  D. Yavagal,et al.  Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions. , 2021, Neurology.

[13]  C. Futter,et al.  Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cells homeostasis. , 2021, Journal of Cell Science.

[14]  Y. Geng,et al.  TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway , 2021, Respiratory Research.

[15]  Bruce A. Corliss,et al.  Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice , 2021, Nature Communications.

[16]  Xiaochen Bo,et al.  clusterProfiler 4.0: A universal enrichment tool for interpreting omics data , 2021, Innovation.

[17]  N. Chattipakorn,et al.  Inhibition of CDK9 attenuates atherosclerosis by inhibiting inflammation and phenotypic switching of vascular smooth muscle cells , 2021, Aging.

[18]  E. Fisher,et al.  Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis. , 2021, Circulation.

[19]  Lian‐Wen Qi,et al.  Neuraminidase 1 and its Inhibitors from Chinese Herbal Medicines: An Emerging Role for Cardiovascular Diseases. , 2021, The American journal of Chinese medicine.

[20]  M. Bennett,et al.  Vascular smooth muscle cells in atherosclerosis:Time for a reassessment. , 2021, Cardiovascular research.

[21]  P. Crocker,et al.  Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation , 2021, Journal of Biomedical Science.

[22]  B. Pfeifer,et al.  Complex natural product production methods and options , 2021, Synthetic and systems biotechnology.

[23]  C. Myung,et al.  Regulation of autophagy by controlling Erk1/2 and mTOR for platelet-derived growth factor-BB-mediated vascular smooth muscle cell phenotype shift. , 2021, Life sciences.

[24]  R. Foo,et al.  Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation , 2020, Frontiers in Immunology.

[25]  Yiming Bi,et al.  Molecular Mechanism of the Effect of Huanglian Jiedu Decoction on Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking , 2020, Journal of diabetes research.

[26]  Z. Yue,et al.  The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis , 2020, Autophagy.

[27]  Ning Wang,et al.  Integrating Network Pharmacology and Experimental Models to Investigate the Efficacy of Coptidis and Scutellaria Containing Huanglian Jiedu Decoction on Hepatocellular Carcinoma. , 2020, The American journal of Chinese medicine.

[28]  Xiushan Wu,et al.  Identification of potential candidate genes and pathways in atrioventricular nodal reentry tachycardia by whole‐exome sequencing , 2020, Clinical and translational medicine.

[29]  F. Sanz,et al.  The DisGeNET knowledge platform for disease genomics: 2019 update , 2019, Nucleic Acids Res..

[30]  F. Zeng,et al.  Role of the Balance of Akt and MAPK Pathways in the Exercise-Regulated Phenotype Switching in Spontaneously Hypertensive Rats , 2019, International journal of molecular sciences.

[31]  Marco Valgimigli,et al.  Updated Expert Consensus Statement on Platelet Function and Genetic Testing for Guiding P2Y12 Receptor Inhibitor Treatment in Percutaneous Coronary Intervention. , 2019, JACC. Cardiovascular interventions.

[32]  Olivier Michielin,et al.  SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules , 2019, Nucleic Acids Res..

[33]  S. Allahverdian,et al.  Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis , 2019, Arteriosclerosis, thrombosis, and vascular biology.

[34]  H. Jneid,et al.  Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association , 2019, Circulation.

[35]  K. Ley,et al.  Immunity and Inflammation in Atherosclerosis , 2019, Circulation research.

[36]  Damian Szklarczyk,et al.  STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets , 2018, Nucleic Acids Res..

[37]  M. Bennett,et al.  Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels , 2018, Nature Communications.

[38]  M. Bennett,et al.  Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis , 2018, Cardiovascular research.

[39]  David S. Wishart,et al.  DrugBank 5.0: a major update to the DrugBank database for 2018 , 2017, Nucleic Acids Res..

[40]  R. Leite,et al.  Transcriptomic analysis of purified human cortical microglia reveals age-associated changes , 2017, Nature Neuroscience.

[41]  Junsong Wang,et al.  Deciphering the mechanism of Huang‐Lian‐Jie‐Du‐Decoction on the treatment of sepsis by formula decomposition and metabolomics: Enhancement of cholinergic pathways and inhibition of HMGB‐1/TLR4/NF‐&kgr;B signaling , 2017, Pharmacological research.

[42]  Tsippi Iny Stein,et al.  The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses , 2016, Current protocols in bioinformatics.

[43]  Joshua D. Hutcheson,et al.  Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation. , 2016, Journal of visualized experiments : JoVE.

[44]  M. Bennett,et al.  Vascular Smooth Muscle Cells in Atherosclerosis. , 2016, Circulation research.

[45]  M. Cattaneo,et al.  P2Y12 receptors: structure and function , 2015, Journal of thrombosis and haemostasis : JTH.

[46]  Zhiping Weng,et al.  ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers , 2014, Bioinform..

[47]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[48]  D. Valle,et al.  Online Mendelian Inheritance In Man (OMIM) , 2000, Human mutation.

[49]  OUP accepted manuscript , 2022, Cardiovascular Research.