Protective role of n6/n3 PUFA supplementation with varying DHA/EPA ratios against atherosclerosis in mice.

[1]  I. Shimomura,et al.  Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treg induction in mice , 2017, Scientific Reports.

[2]  Liang Liu,et al.  Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice , 2017, Lipids in Health and Disease.

[3]  Lloyd H. Michael,et al.  The Guide for the Care and Use of Laboratory Animals. , 2016, ILAR journal.

[4]  R. Murphy,et al.  Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver , 2015, Journal of Lipid Research.

[5]  A. Sala-Vila,et al.  New Insights into the Role of Nutrition in CVD Prevention , 2015, Current Cardiology Reports.

[6]  W. Sheu,et al.  Docosahexaenoic acid and eicosapentaenoic acid suppress adhesion molecule expression in human aortic endothelial cells via differential mechanisms. , 2015, Molecular nutrition & food research.

[7]  O. Jáuregui,et al.  Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome. , 2015, The British journal of nutrition.

[8]  Liang Liu,et al.  Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway. , 2014, The Journal of nutritional biochemistry.

[9]  U. Jung,et al.  Incremental replacement of saturated fats by n-3 fatty acids in high-fat, high-cholesterol diets reduces elevated plasma lipid levels and arterial lipoprotein lipase, macrophages and atherosclerosis in LDLR-/- mice. , 2014, Atherosclerosis.

[10]  J. Torres,et al.  Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome , 2014, Lipids in Health and Disease.

[11]  J. M. Gallardo,et al.  Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats , 2013, Lipids in Health and Disease.

[12]  R. Deckelbaum,et al.  Omega-3 fatty acids: mechanisms underlying ‘protective effects’ in atherosclerosis , 2013, Current opinion in lipidology.

[13]  T. Lüscher,et al.  Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36. , 2013, Atherosclerosis.

[14]  A. Ferro,et al.  Celastrol Prevents Atherosclerosis via Inhibiting LOX-1 and Oxidative Stress , 2013, PloS one.

[15]  Yifan Dai,et al.  Unbalanced omega-6/omega-3 ratio in red meat products in China , 2013, Journal of biomedical research.

[16]  F. Sofi,et al.  The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratio. , 2013, Asia Pacific journal of clinical nutrition.

[17]  J. M. Gallardo,et al.  Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs. , 2013, Free radical biology & medicine.

[18]  E. Ntzani,et al.  Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. , 2012, JAMA.

[19]  M. Koike,et al.  Omega-6 polyunsaturated fatty acids prevent atherosclerosis development in LDLr-KO mice, in spite of displaying a pro-inflammatory profile similar to trans fatty acids. , 2012, Atherosclerosis.

[20]  M. de Lorgeril,et al.  New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids , 2012, BMC Medicine.

[21]  Javier Aranceta,et al.  Recommended dietary reference intakes, nutritional goals and dietary guidelines for fat and fatty acids: a systematic review , 2012, British Journal of Nutrition.

[22]  Guo-Fang Zhang,et al.  Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver. , 2012, Free radical biology & medicine.

[23]  S. Larsson,et al.  Dietary fats and dietary cholesterol and risk of stroke in women. , 2012, Atherosclerosis.

[24]  Y. Marcel,et al.  Regulation of Lipid Droplet Cholesterol Efflux From Macrophage Foam Cells , 2012, Arteriosclerosis, thrombosis, and vascular biology.

[25]  D. Hoyert.  75 years of mortality in the United States, 1935-2010. , 2012, NCHS data brief.

[26]  M. Di Nunzio,et al.  Pro- and anti-oxidant effects of polyunsaturated fatty acid supplementation in HepG2 cells. , 2011, Prostaglandins, leukotrienes, and essential fatty acids.

[27]  G. Francis,et al.  Lysosomal Acid Lipase Deficiency Impairs Regulation of ABCA1 Gene and Formation of High Density Lipoproteins in Cholesteryl Ester Storage Disease* , 2011, The Journal of Biological Chemistry.

[28]  K. Swedberg.  n-3 Fatty acids in cardiovascular disease. , 2011, The New England journal of medicine.

[29]  K. Moore,et al.  Macrophages in the Pathogenesis of Atherosclerosis , 2011, Cell.

[30]  Tzong-Shyuan Lee,et al.  Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells. , 2011, The Journal of nutritional biochemistry.

[31]  I. Leclercq,et al.  Why and How Meet n-3 PUFA Dietary Recommendations? , 2010, Gastroenterology research and practice.

[32]  T. V. van Berkel,et al.  Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions , 2010, Current opinion in lipidology.

[33]  S. Evans,et al.  Dietary n-3:n-6 fatty acid ratios differentially influence hormonal signature in a rodent model of metabolic syndrome relative to healthy controls , 2010, Nutrition & metabolism.

[34]  R. Deckelbaum,et al.  N-3 vs. saturated fatty acids: effects on the arterial wall. , 2010, Prostaglandins, leukotrienes, and essential fatty acids.

[35]  D. Mozaffarian,et al.  Saturated Fat and Cardiometabolic Risk Factors, Coronary Heart Disease, Stroke, and Diabetes: a Fresh Look at the Evidence , 2010, Lipids.

[36]  F. Hu,et al.  Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. , 2010, The American journal of clinical nutrition.

[37]  D. Mozaffarian,et al.  Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials , 2010, PLoS medicine.

[38]  Philip C. Calder,et al.  Effects of Fat and Fatty Acid Intake on Inflammatory and Immune Responses: A Critical Review , 2009, Annals of Nutrition and Metabolism.

[39]  L. D. de Groot,et al.  Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. , 2009, The American journal of clinical nutrition.

[40]  A. Lichtenstein,et al.  Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse. , 2009, Atherosclerosis.

[41]  Kunihiro Suzuki,et al.  Cilostazol inhibits cytokine-induced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells. , 2009, Cardiovascular research.

[42]  M. Mitjavila,et al.  Atherosclerosis prevention by a fish oil-rich diet in apoE(-/-) mice is associated with a reduction of endothelial adhesion molecules. , 2008, Atherosclerosis.

[43]  Yeong-Ok Song,et al.  Effect of bamboo culm extract on oxidative stress and genetic expression: bamboo culm extract ameliorates cell adhesion molecule expression and NFkappaB activity through the suppression of the oxidative stress. , 2008, Clinical nutrition.

[44]  J. Borén,et al.  Ira Tabas , Kevin Jon Williams and Jan Borén and Therapeutic Implications Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis : Update , 2007 .

[45]  J. Morrow,et al.  Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. , 2007, The Journal of nutrition.

[46]  A. Vaughan,et al.  ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL Published, JLR Papers in Press, August 10, 2006. , 2006, Journal of Lipid Research.

[47]  W. Harris,et al.  Tissue omega-6/omega-3 fatty acid ratio and risk for coronary artery disease. , 2006, The American journal of cardiology.

[48]  P. Calder,et al.  Dietary α-linolenic acid and health-related outcomes: a metabolic perspective , 2006, Nutrition Research Reviews.

[49]  Y. Lombardo,et al.  Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review. , 2006, The Journal of nutritional biochemistry.

[50]  R. de Caterina,et al.  Contrasting effect of fish oil supplementation on the development of atherosclerosis in murine models. , 2006, Atherosclerosis.

[51]  J. Giddings,et al.  Varying the ratio of dietary n-6/n-3 polyunsaturated fatty acid alters the tendency to thrombosis and progress of atherosclerosis in apoE-/- LDLR-/- double knockout mouse. , 2005, Thrombosis research.

[52]  E. Benjamin,et al.  Brachial Artery Vasodilator Function and Systemic Inflammation in the Framingham Offspring Study , 2004, Circulation.

[53]  A. Gotto,et al.  Inflammation in Atherosclerosis and Implications for Therapy , 2004, Circulation.

[54]  P. Calder,et al.  The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. , 2004, Prostaglandins, leukotrienes, and essential fatty acids.

[55]  M. Katan,et al.  Dietary α-Linolenic Acid Is Associated with Reduced Risk of Fatal Coronary Heart Disease, but Increased Prostate Cancer Risk: A Meta-Analysis , 2004 .

[56]  M. Katan,et al.  Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. , 2004, The Journal of nutrition.

[57]  G. Siest,et al.  IL-6, TNF-alpha and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort. , 2003, Atherosclerosis.

[58]  Ira Tabas,et al.  Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. , 2002, The Journal of clinical investigation.

[59]  Division on Earth.  Guide for the Care and Use of Laboratory Animals , 1996 .