Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular Functions
暂无分享,去创建一个
M. Huss | J. Bergquist | G. Annéren | Jia Mi | N. Dahl | J. Nordlund | M. Shahsavani | J. Schuster | M. Sobol | A. Konzer | Jan Hoeber | J. Klar | A. Falk | Loora Laan | Mansoureh Shahsavani | Anna Falk
[1] Lin Yao,et al. Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons , 2018, Stem cell reports.
[2] Sara B. Linker,et al. An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis , 2018, Molecular Psychiatry.
[3] T. Kidd,et al. The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene , 2017, PLoS genetics.
[4] M. Korte,et al. Not just amyloid: physiological functions of the amyloid precursor protein family , 2017, Nature Reviews Neuroscience.
[5] Stylianos E. Antonarakis,et al. Down syndrome and the complexity of genome dosage imbalance , 2016, Nature Reviews Genetics.
[6] S. Bölte,et al. Derivation of human iPS cell lines from monozygotic twins in defined and xeno free conditions. , 2017, Stem cell research.
[7] Y. Goda,et al. Integrins in synapse regulation , 2016, Nature Reviews Neuroscience.
[8] S. K. Zaidi,et al. Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling , 2016, Stem cell reports.
[9] O. Yanuka,et al. Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation , 2016, Stem cell reports.
[10] Heather C. Wick,et al. An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome , 2016, Scientific Reports.
[11] Andrew D. Rouillard,et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update , 2016, Nucleic Acids Res..
[12] A. Peters,et al. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination , 2016, Neuron.
[13] M. Stoneking,et al. Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number , 2016, bioRxiv.
[14] N. Kurabayashi,et al. DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model , 2015, EMBO reports.
[15] S. Antonarakis,et al. DNA-Methylation Patterns in Trisomy 21 Using Cells from Monozygotic Twins , 2015, PloS one.
[16] Dean Nizetic,et al. A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome , 2015, Nature Reviews Neuroscience.
[17] S. Antonarakis,et al. Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration , 2015, Stem cells.
[18] Pierre J. Magistretti,et al. A Cellular Perspective on Brain Energy Metabolism and Functional Imaging , 2015, Neuron.
[19] L. Cavelier,et al. Methods of Reprogramming to Induced Pluripotent Stem Cell Associated with Chromosomal Integrity and Delineation of a Chromosome 5q Candidate Region for Growth Advantage. , 2015, Stem cells and development.
[20] W. Huber,et al. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.
[21] J. Johansson,et al. Spider silk for xeno-free long-term self-renewal and differentiation of human pluripotent stem cells. , 2014, Biomaterials.
[22] C. Chen,et al. Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells , 2014, Nature Communications.
[23] Stylianos E. Antonarakis,et al. Domains of genome-wide gene expression dysregulation in Down’s syndrome , 2014, Nature.
[24] S. Antonarakis,et al. Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21 , 2013, EMBO molecular medicine.
[25] Philip D. Gregory,et al. Translating Dosage Compensation to Trisomy 21 , 2013, Nature.
[26] Jason P. Weick,et al. Deficits in human trisomy 21 iPSCs and neurons , 2013, Proceedings of the National Academy of Sciences.
[27] W. A. Tyler,et al. Multiplex Genetic Fate Mapping Reveals a Novel Route of Neocortical Neurogenesis, Which Is Altered in the Ts65Dn Mouse Model of Down Syndrome , 2013, The Journal of Neuroscience.
[28] James Briggs,et al. Integration‐Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology , 2013, Stem cells.
[29] G. Helguera,et al. Adaptive downregulation of mitochondrial function in down syndrome. , 2013, Cell metabolism.
[30] D. Sheff,et al. Immunostaining: detection of signaling protein location in tissues, cells and subcellular compartments. , 2013, Methods in cell biology.
[31] Thomas R. Gingeras,et al. STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..
[32] Giuseppe Esposito,et al. OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors. , 2012, Human molecular genetics.
[33] S. Orkin,et al. A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome , 2012, Science Translational Medicine.
[34] R. Reeves,et al. Trisomy 21 and early brain development , 2012, Trends in Neurosciences.
[35] Matthew Trotter,et al. Capture of Neuroepithelial-Like Stem Cells from Pluripotent Stem Cells Provides a Versatile System for In Vitro Production of Human Neurons , 2012, PloS one.
[36] H. Lehrach,et al. Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes , 2011, BMC Genomics.
[37] Bernhard M. Schuldt,et al. A bioinformatic assay for pluripotency in human cells , 2011, Nature Methods.
[38] B. Pakkenberg,et al. Reduced cell number in the neocortical part of the human fetal brain in Down syndrome. , 2008, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.
[39] R. Bartesaghi,et al. RESEARCH ARTICLE: Neurogenesis Impairment and Increased Cell Death Reduce Total Neuron Number in the Hippocampal Region of Fetuses with Down Syndrome , 2007, Brain pathology.
[40] Brad T. Sherman,et al. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.
[41] A. Holland,et al. Gene expression profiling in the adult Down syndrome brain. , 2007, Genomics.
[42] T. Haydar,et al. Defects in Embryonic Neurogenesis and Initial Synapse Formation in the Forebrain of the Ts65Dn Mouse Model of Down Syndrome , 2007, The Journal of Neuroscience.
[43] C. Epstein,et al. Synaptic and cognitive abnormalities in mouse models of down syndrome: Exploring genotype‐phenotype relationships , 2007, The Journal of comparative neurology.
[44] Dario Greco,et al. Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy , 2007, BMC Genomics.
[45] Fabian Fernandez,et al. Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome , 2007, Nature Neuroscience.
[46] M. Mann,et al. A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC) , 2006, Nature Protocols.
[47] Russell S Kirby,et al. National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999-2001. , 2006, Birth defects research. Part A, Clinical and molecular teratology.
[48] Ingo Ruczinski,et al. Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart , 2005, Genome Biology.
[49] Hernán D. Reisin,et al. Development of interlaminar astroglial processes in the cerebral cortex of control and Down's syndrome human cases , 2005, Experimental Neurology.
[50] R. Malenka,et al. Hippocampal Long-Term Potentiation Suppressed by Increased Inhibition in the Ts65Dn Mouse, a Genetic Model of Down Syndrome , 2004, The Journal of Neuroscience.
[51] H. Cuckle,et al. Mitochondrial dysfunction and Down's syndrome. , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.
[52] N. Driesen,et al. Selective neuroanatornic abnormalities in Down's syndrome and their cognitive correlates , 1995, Neurology.