Nutraceuticals: a piece of history, present status and outlook

Abstract The term “nutraceutical” was coined in 1989 by the Foundation for Innovation in Medicine (New York, US), to provide a name for this rapidly growing area of biomedical research. A nutraceutical was defined as any substance that may be considered a food or part of a food and provides medical or health benefits including the prevention and treatment of disease. Nutraceuticals may range from isolated nutrients, dietary supplements and diets to genetically engineered “designer” foods, herbal products and processed products such as cereals, soups and beverages. Doubtlessly, many of these products possess pertinent physiological functions and valuable biological activities. The ongoing research will lead to a new generation of foods, which will certainly cause the interface between food and drug to become increasingly permeable. The present accumulated knowledge about nutraceuticals represents undoubtedly a great challenge for nutritionists, physicians, food technologists and food chemists. Public health authorities consider prevention and treatment with nutraceuticals as a powerful instrument in maintaining health and to act against nutritionally induced acute and chronic diseases, thereby promoting optimal health, longevity and quality of life.

[1]  K. Fearon,et al.  The anti-catabolic effects of n-3 fatty acids. , 1999, Current opinion in clinical nutrition and metabolic care.

[2]  H. Khoo,et al.  Insulinomimetic effects of myricetin on lipogenesis and glucose transport in rat adipocytes but not glucose transport translocation. , 1996, Biochemical pharmacology.

[3]  P. Fürst A thirty-year odyssey in nitrogen metabolism: from ammonium to dipeptides. , 2000, JPEN. Journal of parenteral and enteral nutrition.

[4]  M. Messina Legumes and soybeans: overview of their nutritional profiles and health effects. , 1999, The American journal of clinical nutrition.

[5]  G. Chihara Recent progress in immunopharmacology and therapeutic effects of polysaccharides. , 1992, Developments in biological standardization.

[6]  M. Osterholm,et al.  The eosinophilia-myalgia syndrome and tryptophan. , 1992, Annual review of nutrition.

[7]  B. Morlion,et al.  P.98 What is the optimum ω-3 to ω-6 fatty acid (FA) ratioof parenteral lipid emulsions in postoperative trauma? , 1997 .

[8]  A. Leaf,et al.  Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids , 1999, Annals of Nutrition and Metabolism.

[9]  P. Fürst,et al.  Isoflavones from tofu are absorbed and metabolized in the isolated rat small intestine. , 2000, The Journal of nutrition.

[10]  T. Fahey,et al.  Immunonutrition: the role of arginine. , 1998, Nutrition.

[11]  V. Piironen,et al.  Functional properties of edible mushrooms. , 2000, Nutrition.

[12]  K. Fearon,et al.  The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. , 1996, Nutrition.

[13]  P. Fürst,et al.  Phloridzin improves absorption of genistin in isolated rat small intestine. , 2004, Clinical nutrition.

[14]  J. Shou,et al.  Effect of dietary protein and amino acids on immune function , 1990, Critical care medicine.

[15]  A. Barbul,et al.  Role of arginine in trauma, sepsis, and immunity. , 1990, JPEN. Journal of parenteral and enteral nutrition.

[16]  G. Miyata,et al.  The nutraceutical benefit, part iii: honey. , 2000, Nutrition.

[17]  K. Fearon,et al.  Down-regulation of the acute-phase response in patients with pancreatic cancer cachexia receiving oral eicosapentaenoic acid is mediated via suppression of interleukin-6. , 1997, Clinical science.

[18]  P. Fürst,et al.  Absorption and metabolism of genistin in the isolated rat small intestine , 2000, FEBS letters.

[19]  P. R. Schloerb,et al.  Total parenteral nutrition with glutamine in bone marrow transplantation and other clinical applications (a randomized, double-blind study) , 1993, JPEN. Journal of parenteral and enteral nutrition.

[20]  H. Adlercreutz Phytoestrogens: epidemiology and a possible role in cancer protection. , 1995, Environmental health perspectives.

[21]  P. Flatt,et al.  Actions of the traditional anti-diabetic plant, Agrimony eupatoria (agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion , 1998, British Journal of Nutrition.

[22]  D. M. Schullian A Translation of Galen's Hygiene (de Sanitate Tuenda) , 1952, Pediatrics.

[23]  Emmanuel U. Opara,et al.  Effect of L-glutamine supplementation on impaired glucose regulation during intravenous lipid administration. , 1996, Nutrition.

[24]  M. Rennie,et al.  Effects of L-glutamine on post-ischaemic cardiac function: protection and rescue. , 1998, Journal of molecular and cellular cardiology.

[25]  D. Häussinger,et al.  Cellular hydration state: an important determinant of protein catabolism in health and disease , 1993, The Lancet.

[26]  M. Miller,et al.  Nitric oxide release in response to gut injury. , 1993, Scandinavian journal of gastroenterology.

[27]  P. Kubes,et al.  Ischemia-reperfusion in feline small intestine: a role for nitric oxide. , 1993, The American journal of physiology.

[28]  D. Karyadi,et al.  Functional food and contemporary nutrition-health paradigm: tempeh and its potential beneficial effects in disease prevention and treatment. , 2000, Nutrition.

[29]  P. Stehle,et al.  Absorption and metabolism of genistein in isolated rat small intestine. , 2000, The Journal of nutrition.

[30]  J. Reynolds,et al.  Arginine, protein malnutrition, and cancer. , 1988, The Journal of surgical research.

[31]  C. Funk Etiology of Deficiency Diseases , 1912, The Indian medical gazette.

[32]  R. Chang,et al.  Functional properties of edible mushrooms. , 2009, Nutrition reviews.

[33]  S. Barnes The chemopreventive properties of soy isoflavonoids in animal models of breast cancer , 1997, Breast Cancer Research and Treatment.

[34]  G. Hardy,et al.  Nutraceuticals and functional foods: introduction and meaning. , 2000, Nutrition.

[35]  P. Fürst,et al.  Old and new substrates in clinical nutrition. , 1998, The Journal of nutrition.

[36]  A. Barbul Arginine and immune function. , 1990, Nutrition.

[37]  P. Fürst,et al.  Fish oil emulsions: what benefits can they bring? , 2000, Clinical nutrition.

[38]  Y. Kaneko,et al.  Potentiation of host resistance against microbial infections by lentinan and its related polysaccharides. , 1992, Advances in experimental medicine and biology.

[39]  C. Day Traditional plant treatments for diabetes mellitus: pharmaceutical foods , 1998, British Journal of Nutrition.