Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
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F. Végran | R. Boidot | C. Michiels | P. Sonveaux | O. Féron
[1] E. Gottlieb,et al. Targeting metabolic transformation for cancer therapy , 2010, Nature Reviews Cancer.
[2] O. Feron,et al. Both host and graft vessels contribute to revascularization of xenografted human ovarian tissue in a murine model. , 2010, Fertility and sterility.
[3] Jian-Lin Fu,et al. Prolyl Hydroxylase EGLN3 Regulates Skeletal Myoblast Differentiation through an NF-κB-dependent Pathway , 2010, The Journal of Biological Chemistry.
[4] R. Boidot,et al. Identification of Cyclooxygenase-2 as a Major Actor of the Transcriptomic Adaptation of Endothelial and Tumor Cells to Cyclic Hypoxia: Effect on Angiogenesis and Metastases , 2010, Clinical Cancer Research.
[5] O. Feron,et al. Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. , 2009, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[6] Howard Y. Chang,et al. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. , 2009, Cancer cell.
[7] J. Gutkind,et al. CXCL8/IL8 Stimulates Vascular Endothelial Growth Factor (VEGF) Expression and the Autocrine Activation of VEGFR2 in Endothelial Cells by Activating NFκB through the CBM (Carma3/Bcl10/Malt1) Complex* , 2009, Journal of Biological Chemistry.
[8] Frederik De Smet,et al. Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization , 2009, Cell.
[9] G. Semenza,et al. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. , 2009, Seminars in cancer biology.
[10] Julien Verrax,et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. , 2008, The Journal of clinical investigation.
[11] R. Deberardinis,et al. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis , 2007, Proceedings of the National Academy of Sciences.
[12] T. K. Hunt,et al. Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. , 2007, Antioxidants & redox signaling.
[13] Stephanie Schulte,et al. Lactate adversely affects the in vitro formation of endothelial cell tubular structures through the action of TGF-beta1. , 2007, Experimental cell research.
[14] R. I. Viji,et al. Endothelial cell response to lactate: Implication of PAR modification of VEGF , 2007, Journal of cellular physiology.
[15] V. Grégoire,et al. Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies. , 2006, Cancer research.
[16] S. Legrand-Poels,et al. NF-κB activation by reactive oxygen species: Fifteen years later , 2006 .
[17] J. Nielsen,et al. Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity , 2006, Proceedings of the National Academy of Sciences.
[18] M. Baumann,et al. Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice. , 2006, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[19] T. K. Hunt,et al. Lactate stimulates endothelial cell migration , 2006, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
[20] C. Dalgard,et al. Reversible Inactivation of HIF-1 Prolyl Hydroxylases Allows Cell Metabolism to Control Basal HIF-1* , 2005, Journal of Biological Chemistry.
[21] P. Watt,et al. Lactate – a signal coordinating cell and systemic function , 2005, Journal of Experimental Biology.
[22] B. Aggarwal,et al. Evodiamine Abolishes Constitutive and Inducible NF-κB Activation by Inhibiting IκBα Kinase Activation, Thereby Suppressing NF-κB-regulated Antiapoptotic and Metastatic Gene Expression, Up-regulating Apoptosis, and Inhibiting Invasion* , 2005, Journal of Biological Chemistry.
[23] T. Schroeder,et al. Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology. , 2004, Current medicinal chemistry.
[24] Jean-Luc Balligand,et al. Caveolin-1 Expression Is Critical for Vascular Endothelial Growth Factor–Induced Ischemic Hindlimb Collateralization and Nitric Oxide–Mediated Angiogenesis , 2004, Circulation research.
[25] Stefan Walenta,et al. Lactate: mirror and motor of tumor malignancy. , 2004, Seminars in radiation oncology.
[26] L. Gladden. Lactate metabolism: a new paradigm for the third millennium , 2004, The Journal of physiology.
[27] S. Wagner,et al. Role of ADP‐ribosylation in wound repair. The contributions of Thomas K. Hunt, MD , 2003, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
[28] Huasheng Lu,et al. Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis* , 2002, The Journal of Biological Chemistry.
[29] Noam Brown,et al. Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors , 2001, Journal of leukocyte biology.
[30] E. Rofstad,et al. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. , 2000, Cancer research.
[31] S. Leibovich,et al. Production of vascular endothelial growth factor by murine macrophages: regulation by hypoxia, lactate, and the inducible nitric oxide synthase pathway. , 1998, The American journal of pathology.
[32] H. Lyng,et al. Correlation of high lactate levels in head and neck tumors with incidence of metastasis. , 1997, The American journal of pathology.
[33] E. Rofstad,et al. Correlation of high lactate levels in human cervical cancer with incidence of metastasis. , 1995, Cancer research.
[34] R. Deberardinis,et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. , 2008, Cell metabolism.
[35] C. Dessy,et al. Tumorigenesis and Neoplastic Progression Caveolin-1 Is Critical for the Maturation of Tumor Blood Vessels through the Regulation of Both Endothelial Tube Formation and Mural Cell Recruitment , 2007 .
[36] J. Nielsen,et al. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[37] S. Legrand-Poels,et al. NF-kappaB activation by reactive oxygen species: fifteen years later. , 2006, Biochemical pharmacology.
[38] B. Aggarwal,et al. Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. , 2005, The Journal of biological chemistry.
[39] D. Wilson,et al. Angiogenesis mediated by metabolites is dependent on vascular endothelial growth factor (VEGF) , 2004, Angiogenesis.
[40] G. Semenzato. TARGETING HIF-1 FOR CANCER THERAPY , 2003 .
[41] M. Dewhirst,et al. Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. , 2001, International journal of radiation oncology, biology, physics.