Frequent down‐regulation of hABH2 in gastric cancer and its involvement in growth of cancer cells

Background and Aim:  Methyl or 1, N6‐ethenoadenine base lesions are frequent and highly‐mutagenic or ‐carcinogenic events in mammalian DNA. Human AlkB homologue‐2 (hABH2), a homologue of the Escherichia coli AlkB protein, has been found to be the principal dioxygenase for the repair of these lesions. Mounting evidence indicates that impaired DNA repair contributes to gastric cancer induction and progression. Whether hABH2 is involved in this malignancy is unknown. The present study was aimed to investigate the expression profile of hABH2 in gastric cancer and the effect of hABH2 on cancer cell growth.

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