The Development of Fluorescence Imaging Systems for Clinical Applications - Part I, Broad-Field Fluorescence Imaging

This article proposed a novel classification on fluorescence imaging for clinical applications, and presented a camera-based instrument to verify the functions by an animal mode. The imaging technologies of fluorescence currently are developed in biological medicine included broad-field fluorescence imaging, point-probe fluorescence imaging, and cross-sectional endoluminal fluorescence imaging respectively. This periodical's editor introduced broad-field fluorescence imaging's latest developments in technology in this issue, and illustrated a photo retouching system for decreasing the fluorescence signal-to-noise ratio in photodynamic therapy (PDT) for skin cancer. The animal test also verified that this camera-based instrument still could capture the red fluorescence under a low-dosed light sensitive drug and the scope of distribution of melanoma cells in the vein could clearly be observed.