A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells.

[1]  E. Tsiani,et al.  Carnosic Acid Attenuates the Free Fatty Acid-Induced Insulin Resistance in Muscle Cells and Adipocytes , 2022, Cells.

[2]  Jidong Cheng,et al.  Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages , 2022, Free Radical Biology and Medicine.

[3]  Xuguang Zhang,et al.  DPHC From Alpinia officinarum Ameliorates Oxidative Stress and Insulin Resistance via Activation of Nrf2/ARE Pathway in db/db Mice and High Glucose-Treated HepG2 Cells , 2022, Frontiers in Pharmacology.

[4]  B. Ren,et al.  Total Sesquiterpene Glycosides from Loquat Leaves Ameliorate HFD-Induced Insulin Resistance by Modulating IRS-1/GLUT4, TRPV1, and SIRT6/Nrf2 Signaling Pathways , 2021, Oxidative medicine and cellular longevity.

[5]  Wen-zong Zhu,et al.  Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Wen-Yu-Jin against Pulmonary Fibrosis in a Mouse Model , 2021, Evidence-based complementary and alternative medicine : eCAM.

[6]  S. Su,et al.  Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs/RAGE and p38 MAPK/NF-κB pathway. , 2021, Journal of ethnopharmacology.

[7]  Haoqun Xie,et al.  Computational study of effective matrix metalloproteinase 9 (MMP9) targeting natural inhibitors , 2021, Aging.

[8]  Z. Dai,et al.  Estimates of Type 2 Diabetes Mellitus Burden Attributable to Particulate Matter Pollution and Its 30-Year Change Patterns: A Systematic Analysis of Data From the Global Burden of Disease Study 2019 , 2021, Frontiers in Endocrinology.

[9]  J. Alkaabi,et al.  Insulin Signal Transduction Perturbations in Insulin Resistance , 2021, International journal of molecular sciences.

[10]  D. James,et al.  The aetiology and molecular landscape of insulin resistance , 2021, Nature Reviews Molecular Cell Biology.

[11]  Qiang Li,et al.  Activation of Glucagon‐Like Peptide‐1 Receptor Ameliorates Cognitive Decline in Type 2 Diabetes Mellitus Through a Metabolism‐Independent Pathway , 2021, Journal of the American Heart Association.

[12]  Jieyu Liu,et al.  Triclosan regulates the Nrf2/HO‐1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons , 2021, Environmental toxicology.

[13]  A. Bertoni,et al.  Microvascular Disease and Incident Heart Failure Among Individuals With Type 2 Diabetes Mellitus , 2021, Journal of the American Heart Association.

[14]  Xinxin Zhou,et al.  Anemarrhena Saponins Attenuate Insulin Resistance in Rats with High-Fat Diet-Induced Obesity via the IRS-1/PI3K/AKT Pathway. , 2021, Journal of ethnopharmacology.

[15]  Linhua Zhao,et al.  In silico network pharmacology and in vivo analysis of berberine-related mechanisms against type 2 diabetes mellitus and its complications. , 2021, Journal of ethnopharmacology.

[16]  Boyan Gao,et al.  Protective Effect of Chrysanthemum morifolium cv. Fubaiju Hot-Water Extracts Against ARPE-19 Cell Oxidative Damage by Activating PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway , 2021, Frontiers in Nutrition.

[17]  J. Arockiaraj,et al.  Deteriorating insulin resistance due to WL15 peptide from cysteine and glycine‐rich protein 2 in high glucose‐induced rat skeletal muscle L6 cells , 2021, Cell biology international.

[18]  B. Sunderland,et al.  Sandalwood seed oil ameliorates hepatic insulin resistance by regulating the JNK/NF-κB inflammatory and PI3K/AKT insulin signaling pathways. , 2021, Food & function.

[19]  Daidi Fan,et al.  Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway. , 2020, European journal of pharmacology.

[20]  H. Ichii,et al.  The Role of the Nrf2 Signaling in Obesity and Insulin Resistance , 2020, International journal of molecular sciences.

[21]  R. Thring,et al.  Sargassum fusiforme fucoidan alleviates high-fat diet-induced obesity and insulin resistance associated with the improvement of hepatic oxidative stress and gut microbiota profile. , 2020, Journal of agricultural and food chemistry.

[22]  Li Fang,et al.  Peptides from walnut (Juglans mandshurica Maxim.) protect hepatic HepG2 cells from high glucose-induced insulin resistance and oxidative stress. , 2020, Food & function.

[23]  H. Ouyang,et al.  Structural characterization of a homopolysaccharide with hypoglycemic activity from the roots of Pueraria lobata. , 2020, Food & function.

[24]  Chang-Hao Yang,et al.  Astaxanthin Protects Retinal Photoreceptor Cells against High Glucose-Induced Oxidative Stress by Induction of Antioxidant Enzymes via the PI3K/Akt/Nrf2 Pathway , 2020, Antioxidants.

[25]  Jun Lyu,et al.  Changing epidemiology of chronic kidney disease as a result of type 2 diabetes mellitus from 1990 to 2017: Estimates from Global Burden of Disease 2017 , 2020, Journal of diabetes investigation.

[26]  Min Wang,et al.  Polyphenol-rich extract of Zhenjiang aromatic vinegar ameliorates high glucose-induced insulin resistance by regulating JNK-IRS-1 and PI3K/Akt signaling pathways. , 2020, Food chemistry.

[27]  Liping Wang,et al.  DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway. , 2020, The Biochemical journal.

[28]  Shijie Cao,et al.  Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells. , 2020, Journal of ethnopharmacology.

[29]  F. Ren,et al.  Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells. , 2020, Journal of dairy science.

[30]  Yan-Dong Zhang,et al.  Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress. , 2020, International journal of biological macromolecules.

[31]  Hui Teng,et al.  Sonchus oleraceus Linn extract enhanced glucose homeostasis through the AMPK/Akt/ GSK-3β signaling pathway in diabetic liver and HepG2 cell culture. , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[32]  Yulong Yin,et al.  Resveratrol Attenuates Oxidative Stress-Induced Intestinal Barrier Injury through PI3K/Akt-Mediated Nrf2 Signaling Pathway , 2019, Oxidative medicine and cellular longevity.

[33]  Jun-nan Hu,et al.  Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice , 2019, Metabolic Brain Disease.

[34]  Qianlei Yang,et al.  The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells. , 2019, Environmental toxicology and pharmacology.

[35]  Li Ma,et al.  Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[36]  Hongyue Wang,et al.  Orientin-mediated Nrf2/HO-1 signal alleviates H2O2-induced oxidative damage via induction of JNK and PI3K/AKT activation. , 2018, International journal of biological macromolecules.

[37]  I. Malami,et al.  A review on the ethnomedicinal uses, phytochemistry and pharmacology of Alpinia officinarum Hance. , 2018, Journal of ethnopharmacology.

[38]  T. Ota,et al.  Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance , 2018, Adipocyte.

[39]  Junsong Wang,et al.  Metabolic switching in the hypoglycemic and antitumor effects of metformin on high glucose induced HepG2 cells , 2018, Journal of pharmaceutical and biomedical analysis.

[40]  Lei Yang,et al.  C-Phycocyanin inhibits hepatic gluconeogenesis and increases glycogen synthesis via activating Akt and AMPK in insulin resistance hepatocytes. , 2018, Food & function.

[41]  R. Rizzuto,et al.  MCU-knockdown attenuates high glucose-induced inflammation through regulating MAPKs/NF-κB pathways and ROS production in HepG2 cells , 2018, PloS one.

[42]  J. Shaw,et al.  IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. , 2018, Diabetes research and clinical practice.

[43]  Xuebo Liu,et al.  EGCG evokes Nrf2 nuclear translocation and dampens PTP1B expression to ameliorate metabolic misalignment under insulin resistance condition. , 2018, Food & function.

[44]  F. Chen,et al.  A new diarylheptanoid from Alpinia officinarum promotes the differentiation of 3T3-L1 preadipocytes , 2018, Natural product research.

[45]  Shan He,et al.  Combination Treatment of Deep Sea Water and Fucoidan Attenuates High Glucose-Induced Insulin-Resistance in HepG2 Hepatocytes , 2018, Marine drugs.

[46]  N. Ip,et al.  Diarylheptanoids from Rhizomes of Alpinia officinarum Inhibit Aggregation of α-Synuclein. , 2017, Journal of Agricultural and Food Chemistry.

[47]  Dhiman Sarkar,et al.  Isolates of Alpinia officinarum Hance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies. , 2016, International immunopharmacology.

[48]  Xingbin Yang,et al.  Tartary buckwheat flavonoids protect hepatic cells against high glucose-induced oxidative stress and insulin resistance via MAPK signaling pathways. , 2016, Food & function.

[49]  P. Newsholme,et al.  Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction , 2015, Oxidative medicine and cellular longevity.

[50]  L. Goya,et al.  Cocoa flavonoids protect hepatic cells against high-glucose-induced oxidative stress: relevance of MAPKs. , 2015, Molecular nutrition & food research.

[51]  Jiajun Zhao,et al.  Dietary Lycium barbarum Polysaccharide Induces Nrf2/ARE Pathway and Ameliorates Insulin Resistance Induced by High-Fat via Activation of PI3K/AKT Signaling , 2014, Oxidative medicine and cellular longevity.