The biochemical basis of increased hepatic glucose production in a mouse model of type 2 (non-insulin-dependent) diabetes mellitus

[1]  C. Roberts,et al.  Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats. , 1994, The Biochemical journal.

[2]  A. Thorburn,et al.  Impaired Regulation of Hepatic Fructose-1,6-Bisphosphatase in the New Zealand Obese Mouse Model of NIDDM , 1993, Diabetes.

[3]  M. Derouet,et al.  Insulin resistance in the GK rat: decreased receptor number but normal kinase activity in liver. , 1993, The American journal of physiology.

[4]  M. Walker,et al.  Peripheral and hepatic insulin sensitivity in non-insulin-dependent diabetes mellitus: effect of nonesterified fatty acids. , 1993, Metabolism: clinical and experimental.

[5]  L. Groop,et al.  Contribution of muscle and liver to glucose-fatty acid cycle in humans. , 1993, The American journal of physiology.

[6]  R. Shulman,et al.  Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. , 1992, The Journal of clinical investigation.

[7]  H. Yki-Järvinen,et al.  Lipolysis and gluconeogenesis from glycerol are increased in patients with noninsulin-dependent diabetes mellitus. , 1992, The Journal of clinical endocrinology and metabolism.

[8]  J. Foley,et al.  Rationale and Application of Fatty Acid Oxidation Inhibitors in Treatment of Diabetes Mellitus , 1992, Diabetes Care.

[9]  P. Björntorp,et al.  Effect of Free Fatty Acids on Insulin Receptor Binding and Tyrosine Kinase Activity in Hepatocytes Isolated From Lean and Obese Rats , 1992, Diabetes.

[10]  E. Kraegen,et al.  Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats , 1991, Diabetes.

[11]  R. Larkins,et al.  Evolution of Insulin Resistance in New Zealand Obese Mice , 1991, Diabetes.

[12]  J. Clore,et al.  In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans. , 1991, The American journal of physiology.

[13]  N. Mcintyre,et al.  Effects of glycogen stores and non-esterified fatty acid availability on insulin-stimulated glucose metabolism and tissue pyruvate dehydrogenase activity in the rat , 1991, Diabetologia.

[14]  E. Kraegen,et al.  Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid , 1991, Diabetes.

[15]  R. Rizza,et al.  Contribution to Postprandial Hyperglycemia and Effect on Initial Splanchnic Glucose Clearance of Hepatic Glucose Cycling in Glucose-Intolerant or NIDDM Patients , 1991, Diabetes.

[16]  A. Consoli,et al.  Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism. , 1990, The Journal of clinical investigation.

[17]  T. Jenssen,et al.  Contribution of Abnormal Muscle and Liver Glucose Metabolism to Postprandial Hyperglycemia in NIDDM , 1990, Diabetes.

[18]  H. Beck-Nielsen,et al.  On the determination of basal glucose production rate in patients with Type 2 (non-insulin-dependent) diabetes mellitus using primed-continuous 3-3H-glucose infusion , 1990, Diabetologia.

[19]  B. Jeanrenaud,et al.  Contribution of glycerol and alanine to basal hepatic glucose production in the genetically obese (fa/fa) rat. , 1990, The Biochemical journal.

[20]  T. Jenssen,et al.  Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration. , 1990, The Journal of clinical investigation.

[21]  L. Groop,et al.  Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. , 1989, The Journal of clinical investigation.

[22]  F. Capani,et al.  Predominant Role of Gluconeogenesis in Increased Hepatic Glucose Production in NIDDM , 1989, Diabetes.

[23]  R. DeFronzo,et al.  Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. , 1989, Metabolism: clinical and experimental.

[24]  T. Sasaoka,et al.  Alteration of Insulin-Receptor Kinase Activity by High-Fat Feeding , 1988, Diabetes.

[25]  H. K. Lee,et al.  Artificial induction of intravascular lipolysis by lipid-heparin infusion leads to insulin resistance in man , 1988, Diabetologia.

[26]  E. Ferrannini,et al.  Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. , 1987, Metabolism: clinical and experimental.

[27]  J. Amatruda,et al.  Normal hepatic insulin receptor autophosphorylation in nonketotic diabetes mellitus. , 1985, Biochemical and biophysical research communications.

[28]  R. DeFronzo,et al.  Hepatic and peripheral insulin resistance: A common feature of Type 2 (non-insulin-dependent) and Type 1 (insulin-dependent) diabetes mellitus , 1982, Diabetologia.

[29]  J. Halter,et al.  The Effect of Chronic Sulfonylurea Therapy on Hepatic Glucose Production in Non-insulin-dependent Diabetes , 1982, Diabetes.

[30]  H. Fozzard,et al.  Intracellular chloride activity in mammalian ventricular muscle. , 1981, The American journal of physiology.

[31]  A. Dunn,et al.  Metabolism of tritium- and 14C-labeled alanine in rats. , 1981, The American journal of physiology.

[32]  H. Mizunuma,et al.  Purification and properties of mouse liver fructose 1,6-bisphosphatase. , 1979, Journal of biochemistry.

[33]  B. Messner,et al.  Optical assay of pyruvate carboxylase in crude liver homogenates. , 1978, Analytical biochemistry.

[34]  F. Rudolph,et al.  Rat liver pyruvate carboxylase. V. Reversible dissociation by chloride salts of monovalent cations. , 1975, The Journal of biological chemistry.

[35]  H. Lardy,et al.  Rat liver pyruvate carboxylase. IV. Factors affeing the regulation in vivo. , 1971, The Journal of biological chemistry.

[36]  W. Brech,et al.  Studies on pyruvate carboxylase in rat and human liver. , 1970, Biochimica et biophysica acta.

[37]  J. Stucki,et al.  Regulation of pyruvate carboxylase in rat liver mitochondria by adenine nucleotides and short chain fatty acids. , 1970, European journal of biochemistry.

[38]  R. Kreisberg,et al.  Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[39]  B. Horecker,et al.  Fructose diphosphatase from rabbit liver. IV. Sulfhydryl groups and their relation to the catalytic activity. , 1965, Archives of biochemistry and biophysics.

[40]  W. Wood,et al.  Fructose diphosphatase from rabbit liver. I. Purification and properties. , 1965, The Journal of biological chemistry.

[41]  R. Steele,et al.  INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT * , 1959, Annals of the New York Academy of Sciences.

[42]  G. Reaven,et al.  The fourth Musketeer — from Alexandre Dumas to Claude Bernard , 2006, Diabetologia.

[43]  A. Consoli,et al.  Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus. , 1992, The Journal of clinical investigation.

[44]  T. Jenssen,et al.  Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. , 1990, Diabetes.

[45]  L. Mandarino,et al.  Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus. , 1988, Metabolism: clinical and experimental.

[46]  J. Peret,et al.  Influence of diet, cortisol and insulin on the activity of pyruvate carboxylase and phosphoenolpyruvate carboxykinase in the rat liver. , 1976, The Journal of nutrition.

[47]  M. Eggstein,et al.  Triglycerides and Glycerol Determination after Alkaline Hydrolysis , 1974 .

[48]  D. Williamson.  l-Alanine Determination with Alanine Dehydrogenase , 1974 .