Photoacoustic thermography of tissue

Abstract. Photoacoustic (PA) techniques can measure temperature in biological tissues because PA signal amplitude is sensitive to tissue temperature. So far, temperature-measuring PA techniques have focused on sensing of temperature changes at a single position. In this work, we photoacoustically measured spatial distribution of temperature in deep tissue. By monitoring the temperature at a single position using a thermocouple, the relationship between the PA signal amplitude and the actual temperature was determined. The relationship was then used to translate a PA image into a temperature map. This study showed that it is possible to calibrate the system for the temperature range of hyperthermia using single-point measurements over a smaller temperature range. Our experimental results showed a precision of −0.8±0.4°C (mean±standard error) in temperature measurement, and a spatial resolution as fine as 1.0 mm. PA techniques can be potentially applied to monitor temperature distribution deep in tissue during hyperthermia treatment of cancer.

[1]  B. Hooper.  Optical-thermal response of laser-irradiated tissue , 1996 .

[2]  R. Seip,et al.  Noninvasive estimation of tissue temperature response to heating fields using diagnostic ultrasound , 1995, IEEE Transactions on Biomedical Engineering.

[3]  Lihong V. Wang,et al.  Deep reflection-mode photoacoustic imaging of biological tissue. , 2007, Journal of biomedical optics.

[4]  Ronald I. Siphanto,et al.  Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis. , 2005, Optics express.

[5]  Alexander A. Oraevsky,et al.  Optoacoustic imaging of blood for visualization and diagnostics of breast cancer , 2002, SPIE BiOS.

[6]  Kirill V. Larin,et al.  Real-time optoacoustic monitoring of temperature in tissues , 1999, Photonics West - Biomedical Optics.

[7]  Andrew G. Glen,et al.  APPL , 2001 .

[8]  P. Wust,et al.  The cellular and molecular basis of hyperthermia. , 2002, Critical reviews in oncology/hematology.

[9]  D. Xing,et al.  Temperature monitoring utilising thermoacoustic signals during pulsed microwave thermotherapy: A feasibility study , 2010, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[10]  Lihong V. Wang,et al.  Thermoacoustic and photoacoustic sensing of temperature. , 2009, Journal of biomedical optics.

[11]  R M Henkelman,et al.  Time and temperature dependence of MR parameters during thermal coagulation of ex vivo rabbit muscle , 1998, Magnetic resonance in medicine.

[12]  Kirill V. Larin,et al.  Real-time optoacoustic monitoring of temperature in tissues , 2005 .

[13]  René M. Botnar,et al.  Radio-frequency-induced thermoablation: monitoring with T1-weighted and proton-frequency-shift MR imaging in an interventional 0.5-T environment. , 1998, Radiology.

[14]  M. McHenry,et al.  Modeling of temperature profile during magnetic thermotherapy for cancer treatment , 2009 .

[15]  Lihong V. Wang,et al.  Prospects of photoacoustic tomography. , 2008, Medical physics.

[16]  Arnold P Reid,et al.  2 – Feasibility study , 1999 .

[17]  Ralf Brinkmann,et al.  Noninvasive optoacoustic temperature determination at the fundus of the eye during laser irradiation. , 2004, Journal of biomedical optics.

[18]  Junjie Yao,et al.  Absolute photoacoustic thermometry in deep tissue. , 2013, Optics letters.

[19]  S. Emelianov,et al.  Photoacoustic imaging and temperature measurement for photothermal cancer therapy. , 2008, Journal of biomedical optics.

[20]  Lihong V. Wang,et al.  Photoacoustic imaging in biomedicine , 2006 .

[21]  Minghua Xu,et al.  Thermoacoustic and Photoacoustic Tomography of Thick Biological Tissues toward Breast Imaging , 2005, Technology in cancer research & treatment.

[22]  Lihong V. Wang,et al.  Temperature mapping using photoacoustic and thermoacoustic tomography , 2012, Photonics West - Biomedical Optics.