Performance evaluation of reverse osmosis technology for selected antibiotics removal from synthetic pharmaceutical wastewater

This study addresses the possibility for low pressure reverse osmosis membrane (RE 2521, CSM) process to serve as an alternative to remove selected antibiotics (ampicillin and amoxicillin) from synthetic wastewater by changing operating conditions such as pH = 3, 6.5 and 10; Pressure = 9, 11 and13 (bar); antibiotic concentration = 10, 255 and 500(mg/L), and temperature = 20, 30 and 40°C. The experiment was designed based on Box-benken, which is a Response Surface methodology design (RSM), using Design Expert software. The concentration of antibiotics was measured by applying a UV-spectrophotometer (Cecil), at the wavelength of 254 nm. Results showed a range of rejection percentage from 73.52% to 99.36% and 75.1% to 98.8%, for amoxicillin and ampicillin, respectively. Considering the solute rejections and the membrane porosity show that the prevailing rejection mechanism of the examined antibiotics by the membrane was the size exclusion effect. The permeate flux for both of the antibiotics was 12–18.73 L/m2.h. Although the permeate flux and antibiotic rejection are influenced by operating pressure, pH, and temperature individually, the interaction between operating parameters did not have noticeable effects. According to the results obtained in this study, the application of RO membrane is recommended for the selected antibiotics to be removed to a considerable degree (up to 95%).

[1]  D. Aga,et al.  Comparison of the occurrence of antibiotics in four full-scale wastewater treatment plants with varying designs and operations. , 2007, Chemosphere.

[2]  Jianlong Wang,et al.  Toxic effects of amoxicillin on the photosystem II of Synechocystis sp. characterized by a variety of in vivo chlorophyll fluorescence tests. , 2008, Aquatic toxicology.

[3]  D. Barceló,et al.  Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. , 2006, Talanta.

[4]  Vicki Chen,et al.  NANOFILTRATION OF TEXTILE WASTEWATER FOR WATER REUSE , 2002 .

[5]  Gang Yu,et al.  Occurrence and removal of pharmaceuticals, caffeine and DEET in wastewater treatment plants of Beijing, China. , 2010, Water research.

[6]  Zhendi Wang,et al.  Multiresidue determination of fluoroquinolone, sulfonamide, trimethoprim, and chloramphenicol antibiotics in urban waters in China , 2008, Environmental toxicology and chemistry.

[7]  Malay Chaudhuri,et al.  Optimization of Fenton process for treatment of amoxicillin, ampicillin and cloxacillin antibiotics in aqueous solution. , 2009, Journal of hazardous materials.

[8]  D. Dolar,et al.  Removal of antibiotics from a model wastewater by RO/NF membranes , 2007 .

[9]  T. Melin,et al.  Removal of endocrine disrupting compounds with membrane processes in wastewater treatment and reuse. , 2004, Water science and technology : a journal of the International Association on Water Pollution Research.

[10]  Ligang Chen,et al.  Determination of fluoroquinolone antibiotics in environmental water samples based on magnetic molecularly imprinted polymer extraction followed by liquid chromatography-tandem mass spectrometry. , 2010, Analytica chimica acta.

[11]  M. Gholami,et al.  Nanofiltration process on dye removal from simulated textile wastewater , 2008 .

[12]  A. E. Greenberg,et al.  Standard methods for the examination of water and wastewater : supplement to the sixteenth edition , 1988 .

[13]  I. Koyuncu,et al.  Removal of hormones and antibiotics by nanofiltration membranes , 2008 .

[14]  S. Costanzo,et al.  The occurrence of antibiotics in an urban watershed: from wastewater to drinking water. , 2009, The Science of the total environment.

[15]  M. Shoda,et al.  Removal of COD and color from livestock wastewater by the Fenton method. , 2008, Journal of hazardous materials.

[16]  Z. Ujang,et al.  Removal of endocrine disrupting chemicals (EDCs) using low pressure reverse osmosis membrane (LPROM). , 2007, Water science and technology : a journal of the International Association on Water Pollution Research.

[17]  I. Koyuncu,et al.  Effect of organic ion on the separation of salts by nanofiltration membranes , 2002 .

[18]  Christopher Bellona,et al.  Factors affecting the rejection of organic solutes during NF/RO treatment--a literature review. , 2004, Water research.

[19]  E. Benito-Peña,et al.  Evaluation of mixed mode solid phase extraction cartridges for the preconcentration of beta-lactam antibiotics in wastewater using liquid chromatography with UV-DAD detection , 2006 .

[20]  R. Spalding,et al.  Enhanced in situ denitrification for a municipal well. , 2004, Water research.

[21]  Abdul Latif Ahmad,et al.  Micellar-enhanced ultrafiltration for removal of reactive dyes from an aqueous solution , 2006 .

[22]  Jaka Sunarso,et al.  Performance of activated carbon and bentonite for adsorption of amoxicillin from wastewater: mechanisms, isotherms and kinetics. , 2009, Water research.

[23]  R. L. Riley,et al.  Transport properties of cellulose acetate osmotic membranes , 1965 .

[24]  R. Stuetz,et al.  The application of membrane bioreactors as decentralised systems for removal of endocrine disrupting chemicals and pharmaceuticals. , 2010, Water science and technology : a journal of the International Association on Water Pollution Research.

[25]  Menachem Elimelech,et al.  Relating Nanofiltration Membrane Performance to Membrane Charge (Electrokinetic) Characteristics , 2000 .

[26]  J. Martínez,et al.  Environmental pollution by antibiotics and by antibiotic resistance determinants. , 2009, Environmental pollution.

[27]  Z. Aksu,et al.  Application of biosorption for penicillin G removal: comparison with activated carbon , 2005 .

[28]  Ligang Chen,et al.  On-line coupling of solid-phase extraction to liquid chromatography-tandem mass spectrometry for the determination of macrolide antibiotics in environmental water. , 2009, Analytica Chimica Acta.

[29]  K. Kimura,et al.  REJECTION OF ORGANIC MICROPOLLUTANTS (DISINFECTION BY-PRODUCTS, ENDOCRINE DISRUPTING COMPOUNDS, AND PHARMACEUTICALLY ACTIVE COMPOUNDS) BY NF/RO MEMBRANES , 2003 .

[30]  Klaus Kümmerer,et al.  Antibiotics in the aquatic environment--a review--part I. , 2009, Chemosphere.

[31]  N. Voulvoulis,et al.  Predicted and measured concentrations for selected pharmaceuticals in UK rivers: implications for risk assessment. , 2006, Water research.

[32]  P. Moulin,et al.  Savings and re-use of salts and water present in dye house effluents , 2004 .

[33]  A. Zhu,et al.  Recovery of clindamycin from fermentation wastewater with nanofiltration membranes. , 2003, Water research.

[34]  G. K. Anderson,et al.  Performance of low pressure reverse osmosis membrane (LPROM) for separating mono- and divalent ions , 1998 .

[35]  Damià Barceló,et al.  Highly sensitive simultaneous determination of sulfonamide antibiotics and one metabolite in environmental waters by liquid chromatography-quadrupole linear ion trap-mass spectrometry. , 2008, Journal of chromatography. A.

[36]  Shane A. Snyder,et al.  Role of membranes and activated carbon in the removal of endocrine disruptors and pharmaceuticals , 2007 .

[37]  D. Barceló,et al.  Environmental risk assessment of pharmaceuticals in rivers: relationships between hazard indexes and aquatic macroinvertebrate diversity indexes in the Llobregat River (NE Spain). , 2010, Environment international.

[38]  D. Barceló,et al.  Rejection of pharmaceuticals in nanofiltration and reverse osmosis membrane drinking water treatment. , 2008, Water research.

[39]  A. Alves,et al.  Amoxicillin degradation at ppb levels by Fenton's oxidation using design of experiments. , 2010, The Science of the total environment.

[40]  M. E. T. Padrón,et al.  Solid-phase microextraction with micellar desorption and HPLC-fluorescence detection for the analysis of fluoroquinolones residues in water samples , 2009, Analytical and bioanalytical chemistry.

[41]  A. Schäfer,et al.  Removal of the natural hormone estrone from aqueous solutions using nanofiltration and reverse osmosis. , 2003, Environmental science & technology.

[42]  A. Brenner,et al.  The use of RO to remove emerging micropollutants following CAS/UF or MBR treatment of municipal wastewater , 2011 .

[43]  A. Mesdaghinia,et al.  Textile Dye Removal by Membrane Technology and Biological Oxidation , 2003 .

[44]  Seunghyun Kim,et al.  Determination of antibiotic compounds in water by on-line SPE-LC/MSD. , 2007, Chemosphere.

[45]  F. W. Gilcreas,et al.  Standard methods for the examination of water and waste water. , 1966, American journal of public health and the nation's health.

[46]  D. Fino,et al.  Electrochemical removal of antibiotics from wastewaters , 2007 .

[47]  G. Jiang,et al.  Determination of sulfonamide compounds in sewage and river by mixed hemimicelles solid-phase extraction prior to liquid chromatography-spectrophotometry. , 2007, Journal of chromatography. A.

[48]  K. Thomas,et al.  Environmental assessment of Norwegian priority pharmaceuticals based on the EMEA guideline. , 2008, Ecotoxicology and environmental safety.